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- 저자 : ( Vera Ong ) (검색결과 2 건)
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( Courtney Duong ),( Thien Nguyen ),( John P. Sheppard ),( Vera Ong ),( Lawrance K. Chung ),( Daniel T. Nagasawa ),( Isaac Yang ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2017 Brain Tumor Research and Treatment Vol.5 No.2
Background Worldwide, approximately 2% of new cancers are of the brain. Five-year survival rates among brain cancer patients have been reported as a little over a third. Differences in clinical outcomes between brain tumor patients of different races remain poorly understood. Methods A retrospective chart review was performed on brain tumor resection patients≥18 years old. Demographics, treatment variables, and survival outcomes were collected. Primary outcomes were length of stay, recurrence rate, progression-free survival (PFS), and overall survival (OS). Results A total of 452 patients were included in analysis. Females and males had nearly a 1:1 ratio (n=242 and n=220, respectively). Mean age was 54.8 years (SD: 14.5 range: 18-90). Females composed 69% (n=48) of Asian patients; males constituted 31% (n=22). Mean age of the Asian pa-tients was 55.9 years (SD: 14.6 range: 26-89). Asian-only cohort tumor pathologies included glioblas-toma (GBM) (n=14), high-grade glioma (n=7), low-grade glioma (n=4), meningioma (n=38), and metastases (n=7). Of the 185 meningioma patients, non-Asian patients comprised 79% of the group (n=146). Of the 65 GBM patients in total, non-Asian patients made up 89% of the GBM cohort (n=58). There were no statistically significant differences between these groups of both cohorts in recurrence (p= 0.1580 and p=0.6294, respectively), PFS (p=0.9662 and p=0.4048, respectively), or OS (p=0.3711 and p=0.8183, respectively). Conclusion Studies evaluating the survival between patients of different racial backgrounds against several tumor varieties are rare. Patients of certain racial backgrounds may need additional consider-ation when being attended to despite the same mutational composition as their counterparts. Repeated studies using national databases may yield more conclusive results.
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( Mara Teresa T. Panlilio ),( Rei Joseph P. Prieto ),( Angela D. Djajakusuma ),( Neil S. Bacaltos ),( Cynthia A. Balagot ),( Jade D. Jamias ),( Ramon L. De Vera ),( Janus P. Ong ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in the Philippines and in the world. Most burden of disease is seen in developing countries, with highest incidence reported in hyperendemic regions for Hepatitis B infection. This study identified the prognostic factors and overall survival of patients with HCC. Methods: This retrospective study included adult patients diagnosed with HCC at two Philippine tertiary hospitals from 2007 to 2014. Demographics, tumor characteristics, risk factors, and treatment outcomes were retrieved through review of medical records. STATA v12 was used to perform univariate and multivariate logistic regression. Overall survival was also determined. Results: Four hundred twenty-nine patients, with a mean age of 59.6+13.2 years (M:F ratio 3.6:1), were included. Almost half (49%) had advanced HCC on diagnosis. Fifty-two percent had documented HBV infection, and liver cirrhosis was present in 56%. Furthermore, tumors were usually solitary (59%). Only 57% were able to proceed with treatment. Significant predictors of survival were surgical resection (OR 0.12, p-value <0.001), Child Turcotte Pugh (CTP) classification (CTP B: OR 2.26, p-value 0.024; CTP C: OR 5.54, p-value 0.013), liver cirrhosis (OR 2.56, p-value 0.007), and portal vein thrombosis (PVT) (OR 2.68, p-value 0.035). Forty-two percent of the patients died, with a median overall survival of 16 months. Conclusions: CTP classification, liver cirrhosis, PVT, and surgical resection were identified as significant predictors of survival in HCC. Due to innate limitations of retrospective studies, a prospective study will help in determination of association between severity of disease and treatment outcomes.
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