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The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients
( Mohamed S. Abdelhalim ),( Ahmed S. Kenawy ),( Heba H. El Demellawy ),( Amany A. Azouz ),( Sarah S. Alghanem ),( Torki Al-otaibi ),( Osama Gheith ),( Mohamed Abd Elmonem ),( Mohammed K. Afifi ),( Rag 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.4
Background: The absorption rates of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (ECMPS) may be influenced by the concomitant use of omeprazole. Methods: One hundred kidney transplant patients were recruited during their outpatient visits, including 50 on MMF and 50 on EC-MPS. At the clinic, a predose mycophenolic acid (MPA) sample (C0) was collected; subsequently, the participants received the proton-pump inhibitor omeprazole along with either MMF or EC-MPS. Two more blood samples were collected at 1.5 and 3.5 hours and used to estimate an area under the curve (AUC) from zero to 12 hours [AUC (0-12)]. Results: The mean number of months after transplant was 92 months. The median AUC (0-12) and C0 results were 62.2 mg·h/L and 2.0 mg/L for the MMF group and 71.9 mg·h/L and 1.8 mg/L for the EC-MPS group (P = 0.160 and 0.225, respectively). Interestingly, 54% of the MMF group and 62% of the EC-MPS group showed AUCs above the target values. The correlation between MPA C0 and the predicted AUC was poor in both groups. Conclusion: Omeprazole can be safely co-administered with either MMF or EC-MPS, as it did not compromise the MPA exposure. Unexpectedly, however, a high percentage of patients presented MPA AUCs exceeding the target value, highlighting the importance of periodically assessing MPA level.