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Lee, Siyoung,Kim, Eunsom,Jhun, Hyunjhung,Hong, Jaewoo,Kwak, Areum,Jo, Seunghyun,Bae, Suyoung,Lee, Jongho,Kim, Busun,Lee, Jungmin,Youn, Sulah,Kim, Somi,Kim, Miyeon,Kim, Hyunwoo,Lee, Youngmin,Choi, Dong American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.28
<P>Although it has been established that diabetes increases susceptibility to infections, the role of insulin (INS) in the immune response is unknown. Here, we investigated the immunological function of INS. Proinsulin dimer (pINSd) was a potent immune stimulus that induced inflammatory cytokines, but mature INS was unable to induce an immune response. An affinity-purified rabbit polyclonal antibody raised against mature IL-1α recognized IL-1α and pINS but failed to detect mature INS and IL-1β. Analysis of the pINS sequence revealed the existence of an INS/IL-1α motif in the C-peptide of pINS. Surprisingly, the INS/IL-1α motif was recognized by monoclonal antibody raised against IL-1α. Deleting the INS/IL-1α motif in pINSd and IL-1α changed their activities. To investigate the pINSd receptor, the reconstitution of IL-1 receptor 1 (IL-1R1) in Wish cells restored pINSd activity that was reversed by an IL-1R antagonist. These data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1.</P>
A highly efficient organic sensitizer for dye-sensitized solar cells
Hwang, Suyoung,Lee, Jung Ho,Park, Chanmoo,Lee, Hoinglae,Kim, Chaekyu,Park, Chiyoung,Lee, Mi-Hyeon,Lee, Wanin,Park, Jihee,Kim, Kyungkon,Park, Nam-Gyu,Kim, Chulhee Royal Society of Chemistry 2007 Chemical communications Vol.2007 No.46
<P>We have synthesized a highly efficient organic dye for a dye-sensitized solar cell; the overall solar-to-energy conversion efficiency was 9.1% at AM 1.5 illumination (100 mW cm<SUP>−2</SUP>): short-circuit current density (<I>J</I><SUB>sc</SUB>) = 18.1 mA cm<SUP>−2</SUP>, open circuit photovoltage (<I>V</I><SUB>oc</SUB>) = 743 mV and fill factor (ff) = 0.675.</P> <P>Graphic Abstract</P><P>A π-conjugated dye with donor–acceptor moieties exhibited high efficiency for a dye-sensitized solar cell. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b709859f'> </P>
Discovery of an Orally Bioavailable Gonadotropin-Releasing Hormone Receptor Antagonist
Kim, Seon-Mi,Lee, Minhee,Lee, So Young,Park, Euisun,Lee, Soo-Min,Kim, Eun Jeong,Han, Min Young,Yoo, Taekyung,Ann, Jihyae,Yoon, Suyoung,Lee, Jiyoun,Lee, Jeewoo American Chemical Society 2016 Journal of medicinal chemistry Vol.59 No.19
<P>We developed a compound library for orally available gonadotropin-releasing hormone (GnRH) receptor antagonists that were based on a uracil scaffold. On the basis of in vitro activity and CYP inhibition profile, we selected 18a (SKI2496) for further in vivo studies. Compound 18a exhibited more selective antagonistic activity toward the human GnRH receptors over the GnRHRs in monkeys and rats, and this compound also showed inhibitory effects on GnRH-mediated signaling pathways. Pharmacokinetic and pharmacodynamic evaluations of 18a revealed improved bioavailability and superior gonadotropic suppression activity compared with Elagolix, the most clinically advanced compound. Considering that 18a exhibited highly potent and selective antagonistic activity toward the hGnRHRs along with favorable pharmacokinetic profiles, we believe that 18a may represent a promising candidate for an orally available hormonal therapy.</P>
Suyoung Lee,Hee Young Yoo,Dong Soo Hwang 한국당과학회 2017 한국당과학회 학술대회 Vol.2017 No.01
Pathogen recognition is a fundamental step in host immune response and survives against infections. Pathogen recognition happens by host cell surface receptor which induces downstream immune responses such as opsonization, phagocytosis. Among that glycan-binding receptor in C-type lectin superfamily form recognition molecules which are crucial to innate immunity. Many C-type lectins found in pathogen bind to glycan array, but host cell doesn't have so it makes distinguish self and non-self. However, some pathogen uses this selective recognition for primary infection and subsequent proliferation in a host. DC-SIGN(CD209) initially dendritic cell-specific ICAM-3-grabbing nonintegrin is one of the C-type lectin family dendritic cell surface receptor which binds with pathogen glycan. DC-SIGN can bind with two classes of carbohydrate structures: N-linked high mannose oligosaccharides, fucosylated oligosaccharides. Crystal structure of CRD from DC-SIGN with oligosaccharide reveal CRD forms 1-to-1 complex with high-mannose oligosaccharides. Surface force apparatus(SFA) is used to quantify interaction force of cell surface receptor and glycans on the target membrane. This kind of force measurements can quantify variations in the adhesion energy between DC-SIGN with ligand density which further reveal the role of ligand spacing in the multivalent interactions of CRDs with ligand. By SFA, binding-site geometry and flexibility in DC-SIGN demonstrated and calcium contributions for Dendritic cell receptors on carbohydrate recognition proved.
Suyoung Lee,Youngsam Yoon,Eunhye Kwon,Jisu Bae,Taewan Jeon,Sunkyoung Shin 한국폐기물자원순환학회 2017 한국폐기물자원순환학회 학술대회 Vol.2017 No.05
As of 2013, approximately 253 domestic incineration facilities including incineration facilities for municipal waste and industrial wastes were collected. The distribution of domestic incineration heat through these incineration facilities is estimated to reach about 1,756 thousands toe by 2013. In this study, a high temperature and pressure boiler was applied to evaluate the improvement effect of power generation efficiency of waste incineration facilities. It is possible to increase the power generation efficiency of the steam turbine by increasing the heat loss of the turbine through the high temperature and pressure depending on the steam pressure and the temperature. The boiler main steam amount is reduced by about 10% due to the high temperature and pressure, but the increase rate of the heat fall rate is larger than the decrease rate of the steam flow rate, so that the power generation efficiency is improved. In case of steam temperature, the steam temperature is increased by 50 ℃ at 500 ℃ and 20 kg/㎠ at the pressure of 20 kg/㎠×300 ℃, and it is increased by 10 kg/㎠ to 60 kg/㎠, electricity production changes were investigated. Electricity production increased with increasing temperature and pressure. The electricity production increased by 51.03 % at 40 kg/㎠×400 ℃ and by 89.07 % at 60 kg/㎠×500 ℃, compared to the standard condition of 20 kg/㎠×300 ℃ for comparison. The boiler main steam amount is reduced by about 10 % due to the high temperature and pressure, but the increase rate of the heat fall rate is larger than the decrease rate of the steam flow rate, so that the power generation efficiency is improved. In case of steam temperature, the steam temperature is increased by 50 ℃ at 500 ℃ and 20 kg/㎠ at the pressure of 20 kg/㎠×300 ℃, and it is increased by 10 kg/㎠ to 60 kg/㎠. Electricity production changes were investigated. Electricity production increased with increasing temperature and pressure. The electricity production increased by 51.03 % at 40 kg/㎠×400 ℃ and by 89.07 % at 60 kg/㎠×500 ℃, compared to the standard condition of 20 kg/㎠×300 ℃ for comparison.