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- 저자 : ( Seung Joo Chon ) (검색결과 51 건)
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( Seung Joo Chon ),( Bo Hyon Yun ),( Yeon Soo Jung ),( Si Hyun Cho ),( Young Sik Choi ),( Suk Young Kim ),( Byung Seok Lee ),( Seok Kyo Seo ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
A decrease in estrogen levels in postmenopausal women is considered to be associated with unfavorable changes in lipid profiles, having effects on cardiovascular complications. Metabolic syndrome is a clinical entity of substantial heterogeneous traits which is a risk factor of acute cardiovascular disease. However, studies evaluating the prevalence of metabolic syndrome and its risk factors in postmenopausal women are still lacking. Therefore, we are to evaluate the effects of 25(OH)D levels on metabolic syndrome with its risk factors in postmenopausal women. This study was performed using data from KNHANES 2008-2010 consisting of 10907 (6543 premenopausal, 4364 postmenopausal) women. Clinical and other objective characteristics, seasonality, components and presence of metabolic syndrome were evaluated according to 25(OH)D levels among postmenopausal Korean women. Vitamin D deficiency was dominant in young aged group, whereas prevalence of metabolic syndrome tends to increase in elderly people. The prevalence of metabolic syndrome did not show any correlation with the levels of vitamin D. Although there were no correlations in between the levels of vitamin D and the prevalence of metabolic syndrome, sufficient 25(OH)D level seemed to have some associations with lower odds of abdominal obesity (OR=0.75(0.59-0.95); p for trends=0.052), and also significant association with lower odds of elevated TGs (OR=0.74(0.58-0.93); p for trends=0.041) in age, seasonality adjusted model among postmenopausal women. We conclude increased levels of 25(OH)D in Korean postmenopausal women do not entirely mean they have a lower risk of having metabolic syndrome. However, maintaining sufficient levels of 25(OH)D represent they do have some associations with components of metabolic syndrome. This shows the metabolic syndrome itself is related to its components, but might also be associated with other aspects, such as molecular pathophysiology which have not been clearly identified.
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Preoperative risk factors in recurrent endometrioma after primary conservative surgery
( Seung Joo Chon ),( Seung Hyeong Lee ),( Joo Hyun Choi ),( Ji Sung Lee ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.4
Objective Endometriosis is a common gynecological disorder caused by ectopic implantation of endometrial glandular and stromal cells outside the uterine cavity. Among several types of endometriosis, endometrioma is the only subtype that could be determined preoperatively using pelvic ultrasonography, and guidelines recommend pathologic confirmation of endometrioma greater than 3 cm in diameter. However, although surgery is performed in cases of endometrioma, endometrioma has a high cumulative rate of recurrence. Therefore, because determining the possibility of recurrence before performance of initial surgery is important, we examined preoperative factors associated with recurrent endometrioma. Methods This was a retrospective, comparative study including 236 patients who visited the outpatient clinic between January 2009 and December 2011. Patients who were pathologically diagnosed with endometrioma were included in this study. They were followed up postoperatively and were divided into two groups according to presence of recurrent endometrioma. Results We examined associations between baseline factors and recurrent endometrioma. In multivariate analysis, dysmenorrhea and cyst septation were statistically significant after adjusting with age, parity, surgical staging and postoperative management. We examined cumulative recurrence free survival within cases of recurrent endometriosis, based on the presence of inner cyst septation. The cumulative recurrence free survival was lower in cases with septation. Conclusion Our study found that recurrent endometrioma is more likely in patients with inner cyst septation and the recurrence occurred within a shorter duration of time than in patients without inner cyst septation on preoperative ultrasonography. Therefore intensive caution and postoperative long term medical therapy would be appropriate in patients with inner cyst septation on preoperative ultrasonography before undergoing primary surgery for endometrioma.
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( Seung Joo Chon ),( Ji Sung Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Immaturity of the endocrine system in controlling normal menstruation cycle frequently results in abnormal uterine bleeding (AUB) and elicits anemia in adolescent girls. This study was conducted to assess the effects of endometrial thickness (ET) and years since menarche on anemia in adolescent girls with AUB. 방법: This is a cross-sectional retrospective study. The data were collected by reviewing charts including complete blood count, and ultrasonographic data of 115 adolescent girls with AUB. Subjects were classified according to ET. Patients with endometrial thickness less than 11 mm were grouped as Group I, and those having endometrial thickness equal to greater than 11 mm were grouped as Group II. Serum hemoglobin (Hb) and incidence of anemia were compared in between the two groups. On the other hand, the subjects were also classified according to age; Group Y (12-15 years old) and group O (16-18 years old). ET, serum Hb, and incidence of anemia were also compared in between these two groups. 결과: The incidence of anemia in all subjects was 67.8% and it was significantly higher in group II than in group I (P-value <0.001). Incidence of severe anemia was 56.9% in group II, which was higher than in group I (P-value =0.039). On the other hand, the incidence of anemia was not significantly different between the group Y and group O. However, the incidence of the severe form of anemia was significantly higher in group Y than in group O (P-value =0.001). 결론: AUB could result in severe anemia in adolescent girls who are vulnerable to anemia, particularly those who are close to menarche or having thick endometrium. Early supervision of AUB is required in order to avoid anemia in adolescent girls with vaginal bleeding without any pelvic organ disease.
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Effect of tibolone on the survival of early stage cervical adenocarcinoma patients
( Seung-ho Lee ),( Yoon-jin Cho ),( Kyung-joo Cho ),( Mee-hyang Ko ),( Sun-young Jung ),( Seung-joo Chon ),( So-yi Lim ),( Kwang-beom Lee ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.5
Objective Gynecologic oncologists are uncertain about the safety of tibolone application in cervical adenocarcinoma (AC) patients. This study examined the possible adverse effects of tibolone on the survival of cervical AC patients. Methods Medical records of 70 cervical AC patients with International Federation of Gynecology and Obstetrics stages IA to IB were reviewed. A bilateral salpingo-oophorectomy was performed in all patients, and survival outcomes between tibolone users (n=38) and non-users (n=32) were compared. Results A comparison of the tibolone users with non-users revealed similar clinicopathological variables. Progression-free survival (P=0.34) and overall survival (P=0.22) were similar in the users and non-users. The risks of progression (hazard ratio [HR], 1.71; 95% confidence interval [CI], 0.46-6.37; P=0.43) and death (HR, 1.59; 95% CI, 0.06-45.66; P=0.79) were also similar in both groups. Conclusion Tibolone has no adverse effect on the survival of cervical AC patients and can be administered safely to this population. These findings may be helpful in improving the quality of life of cervical AC patients.
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( Seung Joo Chon ),( Bo Hyon Yun ),( Sihyun Cho ),( Seok Kyo Seo ),( Byung Seok Lee ),( Young Sik Choi ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: To evaluate the effect of pills containing 3mg drospirenone with 0.02mg ethinyl estradiol in women with polycystic ovary syndrome (PCOS) who were classified according to types of hyperandrogenic status. 방법: 100 women who visited outpatient clinic, diagnosed with PCOS and were treated with oral contraceptive pills at least for 6 months in Severance Hospital from March, 2008 to July 2014 were enrolled in this study. All PCOS patients were diagnosed according to the Rotterdam 2003 consensus criteria were divided into three groups: having clinical and laboratory hyperandrogenism (n=28; Group A), having either clinical or laboratory hyperandrogenism (n=37; Group B), and having neither clinical nor laboratory hyperandrogenism (n=35; Group C). Endocrine (follicular stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), anti-mullerian hormone (AMH)), androgen (testosterone (T), free testosterone index (FTI), 17-hydroxy-progesterone (17-OHP), dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG)), insulin (homeostasis model assessment-estimated insulin resistance (HOMA-IR), glucose, insulin), cardiovascular (homocysteine, C-reactive protein (CRP)) and lipid profiles were measured before and after taking the pills. 결과: The mean durations of taking the pills were 9.93±7.71 months, 8.70±6.00 months, and 8.69±.31 months (p-value = 0.712). Among the three groups, there was significant changes in FTI values before and after the treatment (-5.52±3.06 vs. -2.50±4.39 vs. -1.76±1.39; p-value <0.05). Within each group, changes in laboratory values before and after taking the pills were evaluated, and FTI, 17-OHP, SHBG, HDL-C were found to have significant changes in all three groups. 결론: The pills containing 3mg drospirenone with 0.02mg ethinyl estradiol significantly improve androgen profiles without improving insulin sensitivity, lipid profiles except HDL-C and cardiovascular markers regardless of the subtypes of hyperandrogenism.
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( Seung Joo Chon ),( Yae Kyu Koh ),( Jin Young Heo ),( Jinae Lee ),( Min Kyoung Kim ),( Bo Hyon Yun ),( Byung Seok Lee ),( Seok Kyo Seo ) 대한산부인과학회 2017 Obstetrics & Gynecology Science Vol.60 No.1
Objective We evaluated the combined effects of vitamin D and daily calcium intake on bone mineral density (BMD) and osteoporosis in Korean postmenopausal women. Methods This study is a cross-sectional study consisting of 1,921 Korean postmenopausal women aged 45 to 70 years without thyroid dysfunction, from the 2008-2011 Korean National Health and Nutrition Examination Survey. Participants were classified into six groups according to serum 25-hydroxyvitamin D (25(OH)D) levels and daily calcium intake. BMD was measured using dual-energy X-ray absorptiometry at femur and at lumbar spine, and the serum vitamin D levels were measured by radioimmunoassay. Results The BMD divided according to serum 25(OH)D and daily calcium intakes were not statistically different among the groups. However, when both daily calcium intake and serum 25(OH)D were not sufficient, risk of osteopenia and osteoporosis showed significant increase in both femur neck and lumbar spine (odds ratio [OR] 2.242, P=0.006; OR 3.044, P=0.001; respectively). Although daily calcium intake was sufficient, risks of osteopenia and osteoporosis significantly increased in lumbar spine group if serum 25(OH)D is <20 ng/mL (OR 2.993, P=0.006). Conclusion The combined effects of insufficient daily calcium intake and vitamin D deficiency may cause low BMD and increase in prevalence of osteopenia and osteoporosis in Korean postmenopausal women aged 45 to 70 years.
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( Seung Joo Chon ),( Jin Young Heo ),( Bo Hyon Yun ),( Yeon Soo Jung ),( Seok Kyo Seo ) 대한폐경학회 2016 대한폐경학회지 Vol.22 No.3
Objectives: Menopause is a natural aging process causing estrogen deficiency, accelerating atherogenic processes including dyslipidemia. Prevalence of thyroid dysfunction is also high in postmenopausal women, and it is known to elevate the risk of cardiovascular disease (CVD). Therefore, we are to study on the associations in between serum thyroid stimulating hormone (TSH) and prevalence of CVD in postmenopausal women who have normal thyroid function. Methods: We performed a retrospective review of 247 Korean postmenopausal women who visited the health promotion center from January, 2007 to December, 2009. Postmenopausal women with normal serum TSH were included in the study. Coronary atherosclerosis was assessed by 64-row multidetector computed tomography. Results: In multiple linear regression analysis, serum TSH was associated with serum triglyceride (TG) (β = 0.146, P = 0.023). In multiple logistic regression analysis, increasing age and serum TSH were associated with an increased risk of coronary atherosclerosis in euthyroid postmenopausal women (odds ratio [OR] = 1.107 [1.024-1.197], P = 0.011 and OR = 1.303 [1.024-1.658], P = 0.031, respectively). Conclusions: It revealed that significant predictor of serum TSH was serum TG, and increasing age and TSH were found to have associations with an increased risk of coronary atherosclerosis in euthyroid postmenopausal women. Screening and assessing risks for CVD in healthy postmenopausal women would be helpful before atherosclerosis develops. (J Menopausal Med 2016;22:146-153)
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