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Hyo Lim Lee,Jong Min Kim,Min Ji Go,Seung Gyum Joo,Tae Yoon Kim,Han Su Lee,Ju Hui Kim,Jin-Sung Son,Ho Jin Heo The Korean Society for Microbiology and Biotechnol 2024 Journal of microbiology and biotechnology Vol.34 No.3
This study evaluated the hepatoprotective effect of fermented Protaetia brevitarsis larvae (FPB) in ethanol-induced liver injury mice. As a result of amino acids in FPB, 18 types of amino acids including essential amino acids were identified. In the results of in vitro tests, FPB increased alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activities. In addition, FPB treatment increased cell viability on ethanol- and H<sub>2</sub>O<sub>2</sub>-induced HepG2 cells. FPB ameliorated serum biomarkers related to hepatoxicity including glutamic oxaloacetic transaminase, glutamine pyruvic transaminase, total bilirubin, and lactate dehydrogenase and lipid metabolism including triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Also, FPB controlled ethanol metabolism enzymes by regulating the protein expression levels of ADH, ALDH, and cytochrome P450 2E1 in liver tissue. FPB protected hepatic oxidative stress by improving malondialdehyde content, reduced glutathione, and superoxide dismutase levels. In addition, FPB reversed mitochondrial dysfunction by regulating reactive oxygen species production, mitochondrial membrane potential, and ATP levels. FPB protected ethanol-induced apoptosis, fatty liver, and hepatic inflammation through p-AMP-activated protein kinase and TLR-4/NF-κB signaling pathways. Furthermore, FPB prevented hepatic fibrosis by decreasing TGF-β1/Smad pathway. In summary, these results suggest that FPB might be a potential prophylactic agent for the treatment of alcoholic liver disease via preventing liver injury such as fatty liver, hepatic inflammation due to chronic ethanol-induced oxidative stress.
Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Jong Cheol Kim,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was conducted to assess the protective effect of extract of matcha green tea (EM) against particulate matter (PM)2.5- and H₂O₂-induced dermal damage in primary dermal fibroblast and BALB/c mice. In the results of in vitro cell study, the EM increased the cell viability and decreased ROS production in PM2.5- and H₂O₂-induced primary dermal fibroblast cells by suppressing the inflammatory protein expression of caspse-3, caspase-1, p-JNK, p-NF-κB, COX-2 and IL-1β in primary dermal fibroblast cells. In addition, the EM protected the PM2.5-exposed antioxidant damage in dermal tissue by regulating the reduced GSH contents, SOD activity and MDA levels. The EM attenuated the inflammatory protein expression of TNF-α, TLR4, TLR2, p-JNK, BAX and COX-2 in dermal tissue.
Go Min Ji,Kim Jong Min,Kang Jin Yong,Park Seon Kyeong,Lee Chang Jun,Kim Min Ji,Lee Hyo Rim,Kim Tae Yoon,Joo Seung Gyum,김대옥,허호진 한국미생물·생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.9
In this study, we investigated the anti-amnesic effect of Korean red pine (Pinus densiflora) bark extract (KRPBE) against amyloid beta1-42 (Aβ1-42)-induced neurotoxicity. We found that treatment with KRPBE improved the behavioral function in Aβ-induced mice, and also boosted the antioxidant system in mice by decreasing malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activities, and reducing glutathione (GSH) levels. In addition, KRPBE improved the cholinergic system by suppressing reduced acetylcholine (ACh) content while also activating acetylcholinesterase (AChE), regulating the expression of choline acetyltransferase (ChAT), postsynaptic density protein-95 (PSD-95), and synaptophysin. KRPBE also showed an ameliorating effect on cerebral mitochondrial deficit by regulating reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and ATP levels. Moreover, KRPBE modulated the expression levels of neurotoxicity indicators Aβ and phosphorylated tau (p-tau) and inflammatory cytokines TNF-α, p- IκB-α, and IL-1β. Furthermore, we found that KRPBE improved the expression levels of neuronal apoptosis-related markers BAX and BCl-2 and increased the expression levels of BDNF and p-CREB. Therefore, this study suggests that KRPBE treatment has an anti-amnestic effect by modulating cholinergic system dysfunction and neuroinflammation in Aβ1-42-induced cognitive impairment in mice.
Regulatory Effect of Matcha Green Tea on Fine Dust-Exposed Cytotoxicity in Respiratory System
Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Jong Cheol Kim,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was performed to evaluate the protective effect of matcha green tea on particulate matter (PM)2.5-indued nasal and pulmonary cytotoxicity. The matcha green tea increased the cell viability and inhibited the ROS production in PM2.5-induced cytotoxicity in nasal RPMI2650 and pulmonary A549 cells. The matcha green tea regulated the expression of apoptosis, such as p-Akt, BCl-2, caspase-3, caspase-1 and HO-1, and inflammation, such as TLR4, TLR4 and Nrf2, in PM2.5-indued RPMI2650 cells. In addition, the matcha green tea showed regulatory effect of the apoptosis and inflammatory effect by increasing the BCl-2 and suppressing the caspase-3, TLR4, TNF-α and COX-2 in A549 cells. In addition, the matcha green tea suppressed antioxidant deficits by regulating the reduced GSH contents, SOD activities and MDA levels, and ameliorated the mitochondrial dysfunction by regulating the mitochondrial ROS production, mitochondrial membrane potential and ATP contents in pulmonary tissue. Ultimately, consumption of matcha green tea down-regulated the inflammatory proteins such as TNF-α, p-JNK, p-IκB-α, p-NF-κB and COX-2 in lung tissue.
Hye Rin Jeong,Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was investigated to evaluate a protective effect of ethyl acetate fraction from Cedrela sinensis (EFCS) on H₂O₂ and corticosterone-induced oxidative stress in hippocampal HT22 and human neuroblastoma MC-IXC cells. 40% ethanolic extracts of Cedrela sinensis showed higher total phenolic and total flavonoid contents than other ethanolic extracts. The EFCS showed the significant, 2,2"-azino-bis (3-ethyl benzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. The EFCS presented significant antioxidant capacity by evaluating the ferric reducing/antioxidant power (FRAP). The EFCS showed considerable inhibitory effect of malondialdehyde (MDA) levels and acetylcholinesterase (AChE) activity. In addition, the EFCS inhibited ROS production and increased cell viability in H₂O₂ and corticosterone-induced cytotoxicity in HT22 and MC-IXC cells. Main physiologically compounds of EFCS were identified as rutin, isoquercetin, ethyl gallate, quercetin, kampferol-3-O-rhamnose and ethyl digallate using ultrahigh performance liquid chromatography-quadrupole time of flight/mass spectrometer (UPLC-QTOF/MS).
Hyo Lim Lee,Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was conducted to assess the synbiotics interaction between the Corni fructus and Lactobacillus reuteri in a dextran sulfate sodium (DSS)-induced colitis and cognitive dysfunction in C57BL/6 mice. Mice were treated with Corni fructus (PRE; prebiotics), Lactobacillus reuteri (PRO; probiotics), and synbiotics (SYN; combination of Lactobacillus reuteri and Corni fructus) for 3 weeks. Consumption of PRE, PRO and SYN ameliorated body weight loss and colon-length shortening. Those treatments improved intestinal permeability by decreasing of in serum and increasing of tight junction protein expression in colonic tissue. Those also decreased the expression of inflammatory cytokine, and the myeloperoxidase activity. Especially, SYN significantly increased the content of short chain fatty acids in colitis mice fecal compared to PRE and PRO. Furthermore, PRE, PRO and SYN improved behavioral dysfunction by evaluating the Y-maze and passive avoidance tests. SYN significantly protected the antioxidant damages and cholinergic dysfunction, and regulated protein expression of acetylcholinesterase and choline acetyltransferase compared with PRE and PRO.
Min Ji Go,Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Tae Yoon Kim,Seung Gyum Joo,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, the improvement effect of Korean red pine (Pinus densiflora) bark extract (PineXol<SUP>®</SUP>) against the behavioral dysfunction and neurotoxicity in amyloid beta (Aβ)1-42-induced ICR mice was confirmed. Consumption of PineXol<SUP>®</SUP> improved learning and memory dysfunctions compared to the Aβ group by evaluating the Y-maze, passive avoidance and Morris water maze tests. The PineXol<SUP>®</SUP> regulated acetylcholinesterase (AChE) activity, acetylcholine (ACh) content and expression of choline acetyltransferase (ChAT) and AChE related to a cholinergic system. In addition, the PineXol<SUP>®</SUP> restored antioxidant defisit by regulating the malondialdehyde (MDA) and reduced glutathione (GSH) levels in mouse brain tissue. Furthermore, PineXo<SUP>l®</SUP> significantly improved mitochondrial activity by ameliorating the mitochondrial membrane potential (MMP) and mitochondrial reactive oxygen species (ROS) level.