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RISS 인기검색어
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- 저자 : ( Sam T. Hwang ) (검색결과 3 건)
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The Role of Tumor Microenvironment in Mycosis Fungoides and Sézary Syndrome
( Zhaorui Liu ),( Xuesong Wu ),( Sam T. Hwang ),( Jie Liu ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.6
Mycosis fungoides (MF) and Sezary syndrome (SS) are the most common subtypes of cutaneous T-cell lymphomas (CTCLs). Most cases of MF display an indolent course during its early stage. However, in some patients, it can progress to the tumor stage with potential systematic involvement and a poor prognosis. SS is defined as an erythrodermic CTCL with leukemic involvements. The pathogenesis of MF and SS is still not fully understood, but recent data have found that the development of MF and SS is related to genetic alterations and possibly to environmental influences. In CTCL, many components interacting with tumor cells, such as tumor-associated macrophages, fibroblasts, dendritic cells, mast cells, and myeloid-derived suppressor cells, as well as with chemokines, cytokines and other key players, establish the tumor microenvironment (TME). In turn, the TME regulates tumor cell migration and proliferation directly and indirectly and may play a critical role in the progression of MF and SS. The TME of MF and SS appear to show features of a Th2 phenotype, thus dampening tumorrelated immune responses. Recently, several studies have been published on the immunological characteristics of MF and SS, but a full understanding of the CTCL-related TME remains to be determined. This review focuses on the role of the TME in MF and SS, aiming to further demonstrate the pathogenesis of the disease and to provide new ideas for potential treatments targeted at the microenvironment components of the tumor.
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Supersonically sprayed gas- and water-sensing MIL-100(Fe) films
Lee, Jong-Gun,Joshi, Bhavana N.,Samuel, Edmund,An, Seongpil,Swihart, Mark T.,Lee, Ji Sun,Hwang, Young Kyu,Chang, Jong-San,Yoon, Sam S. ELSEVIER SCIENCE 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.722 No.-
<P><B>Abstract</B></P> <P>Highly uniform, mechanically stable, dense, and water-adsorbing MIL-100(Fe) films were fabricated via supersonic spraying, a rapid, high-throughput, and scalable method compatible with roll-to-roll processing. The film surface area (1667 m<SUP>2</SUP> g<SUP>−1</SUP>) was comparable to that of the nanoparticles from which it was prepared (2009 m<SUP>2</SUP> g<SUP>−1</SUP>), and was higher than previously reported values for MIL-100(Fe) films. The gas and water adsorption abilities of the film were tested by nitrogen physisorption and water adsorption at 30 °C. The supersonically sprayed film was mechanically resistant up to a critical scratching load of 1.84 N, higher than the critical scratchability loads of dip-coated or spin-coated films. In humidity-sensing applications, films that incorporated conductive Ag nanowires were highly responsive to environmental humidity, demonstrating applicability as water vapor sensors. The fabricated films were characterized by X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Highly uniform, mechanically stable, dense, and water-adsorbing MIL-100(Fe) films were fabricated via supersonic spraying. </LI> <LI> The film surface area was the highest value reported in the literature. </LI> <LI> The supersonically sprayed film was mechanically resistant up to a critical scratching load of 1.84 N. </LI> <LI> The fabricated films were highly responsive to environmental humidity, demonstrating applicability as water vapor sensors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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