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이중원(Lee, Joongwon),이경아(Lee, Kyung-A),손세형(Sohn, Saehyung) 한국도시설계학회 2012 도시설계 : 한국도시설계학회지 Vol.13 No.6
본 연구의 목표는 철로 부지 활용을 통해 낙후된 구도심의 재생 및 활성화 방안을 마련하는데 있다. 구도심의 문제점을 도출하고, 문재 해결을 위한 재생 계획 요소 및 마스터플랜을 제시하며, 재생 효과를 분석하고자 한다. 구도심 지상철 역세권 분석 결과, 철로가 도심 내 심한 단절요소로 작용하여 단절된 두 지역의 연계 성장을 저해할 뿐만 아니라, 지역의 낙후를 가속화하는 문제가 있다. 역 광장 주변 인근도로의 주차장화는 시간이 갈수록 심해지고 있으며 문화 컨텐츠프로그램의 부족은 젊은 층의 유입을 저해하고 있다. 지역 주민을 위한 공원 및 어메니티 시설의 부족 또한 커뮤니티의 낙후를 가속화 한다. 구도심 역세권 재생 계획 요소로써 입체 녹지 네트워크, 오픈 스페이스, 새로운 역사 제안, 입체 동선체계 및 인근 지역 주민에 대응하는 역세권 프로그램을 제안하고 있고, 이것들의 재생 효과를 검토하고 있다. 본 연구는 인천시 경인선 도원역세권을 실 사례로 검토하고 있다. 본 연구의 한계는 하나의 구체적인 역을 대상으로 하기 때문에 특수한 상황에 대한 도시 재생 계획 요소 및 재생 효과인 점이다. The goal of this research is to regenerate the old urban centers by rehabilitating the railway district. The procedure is as follows; first, draw the problems of existing railway station and its district in the old urban centers; second, propose regenerating design strategies and; third, analyze the possible effects by the strategies proposed. The problems of the railway station and its district were; first, the above-ground railway functioned as a urban barrier; second, the adjacent roads became parking lots; third, deficiency in the provision of cultural contents and public amenity facilities dissuaded the young generation to move into the urban centers. To solve these inherent problems, this research proposes three-dimensional green network system, openspace, renovation of the station building, complex circulation system, and community-based urban programs as solutions. Corresponding effects are also reviewed. The limitation of the research is paradoxically from the selection of a particular site. The claims of the research are subjected to be site-specific. The next research should be a comparative analysis on, at least, three stations to meet the shortcomings of this research.
( Na Young Kim ),( Kyung-eui Park ),( Yong Jin Lee ),( Yeong Mun Kim ),( Sung Hyun Hong ),( Won Rak Son ),( Sungyoul Hong ),( Saehyung Lee ),( Hye Bin Ahn ),( Jaehyuk Yang ),( Jong-pil Seo ),( Yoon-Ky 한국미생물생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.7
Botulinum neurotoxins (BoNTs), produced by Clostridium botulinum, are the most toxic substances known. However, the number of currently approved medical countermeasures for these toxins is very limited. Therefore, studies on therapeutic antitoxins are essential to prepare for toxin-related emergencies. Currently, more than 10,000 Halla horses, a crossbreed between the native Jeju and Thoroughbred horses, are being raised in Jeju Island of Korea. They can be used for equine antitoxin experiments and production of hyperimmune serum against BoNT/A1. Instead of the inactivated BoNT/A1 toxoid, Halla horse was immunized with the receptor-binding domain present in the C-terminus of heavy chain of BoNT/A1 (BoNT/A1-HCR) expressed in Escherichia coli. The anti-BoNT/A1-HCR antibody titer increased rapidly by week 4, and this level was maintained for several weeks after boosting immunization. Notably, 20 μl of the week-24 BoNT/A1-HCR(-immunized) equine serum showed an in vitro neutralizing activity of over 8 international units (IU) of a reference equine antitoxin. Furthermore, 20 μl of equine serum and 100 μg of purified equine F(ab’)<sub>2</sub> showed 100% neutralization of 10,000 LD<sub>50</sub> in vivo. The results of this study shall contribute towards optimizing antitoxin production for BoNT/A1, which is essential for emergency preparedness and response.