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- 저자 : ( R. Burnett ) (검색결과 4 건)
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R.M. Levy,B.P. Burnett,Q. Jia,Y. Zhao 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.3
A mixed extract containing two naturally occurring flavonoids, baicalin from Scutellaria baicalensisand cat-echin from Acacia catechu, was tested for cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibition via enzyme, cellu-lar, and in vivomodels. The 50% inhibitory concentration for inhibition of both ovine COX-1 and COX-2 peroxidase enzymeactivities was 15 .g/mL, while the mixed extract showed a value for potato 5-LOX enzyme activity of 25 .g/mL. ProstaglandinE2 generation was inhibited by the mixed extract in human osteosarcoma cells expressing COX-2, while leukotriene produc-tion was inhibited in both human cell lines, immortalized THP-1 monocyte and HT-29 colorectal adenocarcinoma. In an arachi-donic acid-induced mouse ear swelling model, the extract decreased edema in a dose-dependent manner. When arachidonicacid was injected directly into the intra-articular space of mouse ankle joints, the mixed extract abated the swelling and re-stored function in a rotary drum walking model. These results suggest that this natural, flavonoid mixture acts via “dual in-hibition” of COX and LOX enzymes to reduce production of pro-inflammatory eicosanoids and attenuate edema in an in vivomodel of inflammation.
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Mark W. Ball,Zeyad R. Schwen,Joan S. Ko,Alexa Meyer,George J. Netto,Arthur L Burnett,Trinity J. Bivalacqua 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.1
Purpose: To determine the impact of lymph node density (LND) on survival after inguinal lymph node dissection (ILND) for penile cancer. Materials and Methods: Our institutional penile cancer database was queried for patients who underwent ILND. Clinicopathologic characteristics including LND and total number of positive lymph nodes (LNs) were analyzed to determine impact on recurrence-free survival (RFS) and overall survival (OS). LND, or the percent of positive LN out of total LN, was calculated as a categorical variable at varying thresholds. Results: Twenty-eight patients with complete follow-up were identified. Indications for ILND were stage >T2 in 20 patients (71.4%), palpable adenopathy in 7 (25%), high grade T1 in 1 (3.6%). Median node yield was 17.5 (interquartile range, 12−22), and positive LNs were found in 14 patients (50%). RFS and OS were significantly lower for patients with >15% LN density (median RFS: 62 months vs. 6.3 months, p=0.0120; median OS: 73.6 months vs. 6.3 months, p<0.001). Controlling for age, medical comorbidities, number of positive LN, T stage, pelvic LN status and indication, LN density >15% was independently associated with worse RFS (hazard ratio [HR], 3.6; p=0.04) and OS (HR, 73.6; p=0.002). The c-index for LND was higher than total positive LNs for RFS (0.64 vs. 0.54) and OS (0.79 vs. 0.61). Conclusions: In this small, retrospective penile cancer cohort, the presence of nodal involvement >15% was associated with decreased RFS and OS, and outperformed total number of positive LN as a prognostic indicator.
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( P. Stirling ),( N. D. Clement ),( D. Macdonald ),( J. T. Patton ),( R. Burnett ),( G. J. Macpherson ) 대한슬관절학회 2019 대한슬관절학회지 Vol.31 No.1
Aims: The primary study aim was to compare early knee-specific function of patients undergoing cemented total knee arthroplasty (TKA) with either a cruciate-retaining (CR) polyethylene insert or a highly congruent condylarstabilizing (CS) insert. Secondary aims were to compare general health and satisfaction between the groups. Methods: A total of 418 consecutive primary TKAs were identified retrospectively. Demographics and preoperative and 1-year postoperative patient-reported outcome measures (PROMs) were collected prospectively. PROMs consisted of Oxford Knee Scores, EuroQol-5 Dimensions scores, and Short Form-12 scores. Results: A total of 54 (12.9%) patients received a CS insert and 364 patients received a CR TKA. The CS group had a significantly (odds ratio (OR) 2.9; p = 0.002) greater proportion of females (77.8% versus 54.9%). The only significant difference in postoperative PROMs was a higher Short Form-12 physical component score in the CR group (difference 3.1; 95% confidence interval (CI) 0.1 to 6.1; p = 0.04). Linear regression analysis demonstrated no significant difference for all postoperative PROMs (p > 0.25). There was no significant difference in satisfaction rate (OR 0.94; 95% CI 0.42 to 2.12; p = 0.56) or pain visual analogue score (difference 6.1; 95% CI -1.9 to 14.0; p = 0.14) between the groups. Conclusion: More congruent CS inserts have equivalent PROMs and patient satisfaction at 1 year compared with less congruent CR inserts. These represent an option for surgeons undertaking TKA where increased congruency is desired.
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