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Deducing Isoform Abundance from Exon Junction Microarray
Kim Po-Ra,Oh S.-June,Lee Sang-Hyuk Korea Genome Organization 2006 Genomics & informatics Vol.4 No.1
Alternative splicing (AS) is an important mechanism of producing transcriptome diversity and microarray techniques are being used increasingly to monitor the splice variants. There exist three types of microarrays interrogating AS events-junction, exon, and tiling arrays. Junction probes have the advantage of monitoring the splice site directly. Johnson et al., performed a genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays (Science 302:2141-2144, 2003), which monitored splicing at every known exon-exon junctions for more than 10,000 multi-exon human genes in 52 tissues and cell lines. Here, we describe an algorithm to deduce the relative concentration of isoforms from the junction array data. Non-negative Matrix Factorization (NMF) is applied to obtain the transcript structure inferred from the expression data. Then we choose the transcript models consistent with the ECgene model of alternative splicing which is based on mRNA and EST alignment. The probe-transcript matrix is constructed using the NMF-consistent ECgene transcripts, and the isoform abundance is deduced from the non-negative least squares (NNLS) fitting of experimental data. Our method can be easily extended to other types of microarrays with exon or junction probes.
라일옥,김포옥,Ra, Ill-Ok,Kim, Po-Ok 한국비블리아학회 2006 한국비블리아학회지 Vol.17 No.2
Objects which has been used for administration is a part of archives that holding merit of history, merit of evidence and merit of administration. But it does not be treated carefully as archival material also, it can not be found a study for the archival objects. Thus this study aims to suggest a description of the objects for management the objects appropriately. To derive a conclusion, this paper made a comparative by using the archival description of other nations such as General International Standard for Archival Description, Rules for Archival Description also refer to the cataloging rules which used for a long time to management materials at library such as Anglo-American Cataloging Rules, Korean Cataloging Rules. We divided the section into 7 area such as identity statement area, context area, content and structure area, condition of access and use area, allied material area, note area, and description control area for suggest a description for archival objects.