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자동차용 솔레노이드 밸브의 Nd:YAG 레이저 용접 특성에 관한 연구
지수환(Suhwan Ji),권오균(Okyun kwon),강동포(Dongpo Kang),최성용(Sungyoung Choi),김인호(Inho Kim) 한국자동차공학회 2002 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2002 No.5_3
ABS (Anti-lock Brake System), TCS (Traction Control System), ESP (Electronic Stability Program) are the brake system which make vehicles more be safety. In order to fulfill the control of vehicle, those systems use a fluid control system ABS consists of several parts such as HU (Hydraulic Unit), ECU and sensors. Especially, solenoid valves operate the fluid pressure control by magnetic force. Generally, the high pressure is worked on hydraulic unit including solenoid valves. In order to shield between sleeve and housing which play an important part in solenoid valve, Nd:YAG laser welding was performed Welding parnmeter such as power, welding speed, repetition rate, pulse width were varied in this experiment The optimwn welding condition observed 47W power, 3.5 ms pulse width, 12 Hz frequencies. Hot cracks that have an effect on a mechanical performance were not observed in the weld metal. Burst test showed that all welded specimens were satisfied at the specification of solenoid valve.
Seung-Lark Hwang,Okyun Kwon,Sun-Gyun Kim,이인규,김영덕 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.5
Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a crucial regulator in GLP-1-induced insulin gene expression and insulin secretion via upregulation of pancreatic duodenal homeobox-1 (PDX-1) in pancreatic b-cells. GLP-1 treatment significantly increased BTG2, PDX-1 and insulin gene expression in pancreatic b-cells. Notably, adenovirus-mediated overexpression of BTG2 significantly elevated insulin secretion, as well as insulin and PDX-1 gene expression. Physical interaction studies showed that BTG2 is associated with increased PDX-1 occupancy on the insulin gene promoter via a direct interaction with PDX-1. Exendin-4 (Ex-4), a GLP-1 agonist, and GLP-1 in pancreatic b-cells increased insulin secretion through the BTG2–PDX-1–insulin pathway, which was blocked by endogenous BTG2 knockdown using a BTG2 small interfering RNA knockdown system. Finally, we revealed that Ex-4 and GLP-1 significantly elevated insulin secretion via upregulation of the BTG2–PDX-1 axis in pancreatic islets, and this phenomenon was abolished by endogenous BTG2 knockdown. Collectively, our current study provides a novel molecular mechanism by which GLP-1 positively regulates insulin gene expression via BTG2,suggesting that BTG2 has a key function in insulin secretion in pancreatic b-cells.
Kim, Su Jeong,Lu, Yue,Kwon, Okyun,Hwangbo, Kyoung,Seo, Chang-Seob,Lee, Seung Ho,Kim, Cheorl-Ho,Chang, Young-Chae,Son, Jong Keun,Chang, Hyeun Wook Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.11
<P>In this study, manassantin A (Man A), an herbal medicine isolated from <I>Saururus chinensis</I> (<I>S. chinensis</I>), markedly inhibited 5-lipoxygenase (5-LO)-dependent leukotriene C<SUB>4</SUB> (LTC<SUB>4</SUB>) generation in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To investigate the molecular mechanisms underlying the inhibition of LTC<SUB>4</SUB> generation by Man A, we assessed the effects of Man A on phosphorylation of cytosolic phospholipase A<SUB>2</SUB> (cPLA<SUB>2</SUB>) and mitogen-activated protein kinases (MAPKs). Inhibition of LTC<SUB>4</SUB> generation by Man A was accompanied by a decrease in cPLA<SUB>2</SUB> phosphorylation, which occurred <I>via</I> the MAPKs including extracellular signal-regulated protein kinase-1/2 (ERK1/2) as well as p38 and c-Jun N-terminal kinase (JNK) pathways. Taken together, the present study suggests the Man A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases.</P>
Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway
( Yue Lu1 ),( Xian Li ),( Young Na Park ),( Okyun Kwon ),( Donggen Piao ),( Young Chae Chang ),( Cheorl Ho Kim ),( Eunkyung Lee ),( Jong Keun Son ),( Hyeun Wook Chang ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.3
The aim of this study was to determine whether britanin, isolated from the flowers of Inula japonica (Inulae Flos), modulates the generation of allergic inflammatory mediators in activated mast cells. To understand the biological activity of britanin, the authors investigated its effects on the generation of prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and degranulation in IgE/Ag-induced bone marrow-derived mast cells (BMMCs). Britanin dose dependently inhibited degranulation and the generations of PGD2 and LTC4 in BMMCs. Biochemical analyses of IgE/Ag-mediated signaling pathways demonstrated that britanin suppressed the phosphorylation of Syk kinase and multiple downstream signaling processes, including phospholipase Cγ1 (PLCγ1)-mediated calcium influx, the activation of mitogen-activated protein kinases (MAPKs; extracellular signal-regulated kinase 1/2, c Jun NH2-terminal kinase and p38), and the nuclear factor-κB (NF-κB) pathway. Taken together, the findings of this study suggest britanin suppresses degranulation and eicosanoid generation by inhibiting the Syk-dependent pathway and britanin might be useful for the treatment of allergic inflammatory diseases.