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Soongoo Hong,Narang Kim,Seongbae Lim 한국인터넷전자상거래학회 2015 인터넷전자상거래연구 Vol.15 No.5
Many small and medium-sized manufacturing enterprises(SMMEs) have introduced and operated Production Information Systems(PISs). While previous studies evaluated performance immediately before and after system implementation, few investigated the operational performance of PIS, which focuses on the performance over a given period after system implementation. This study analyzes the differences between performance immediately after system implementation(establish and stabilization period) and the performance after a given period of time(operational phase). It also investigates factors that positively influence operational performance. The results showed that downtime decreased more in the operational phase than in the establishment and stabilization phases. In addition, the CEO’s support, user training, system improvement and maintenance, and the expertise and interest of the person in charge of a system were all identified as critical success factors influencing the operational performance of PISs.
Tuberculous Lymphadenitis in a Patient Treated with Dupilumab: A Case Report
( Dong Heon Lee ),( Narang Hong ),( Hyung Don Kook ),( Hye Jung Jung ),( Mi Yeon Park ),( Jiyoung Ahn ) 대한피부과학회 2023 Annals of Dermatology Vol.35 No.7
Tuberculous lymphadenitis is among the most frequent presentations of extrapulmonary tuberculosis; the most common presentation is isolated chronic non-tender lymphadenopathy in young adults without systemic symptoms. Dupilumab is a fully human monoclonal antibody directed against interleukin-4 receptor-α that blocks the synergistic effects of interleukin-4 and interleukin-13 on allergic inflammation. Its well-known adverse events are allergic conjunctivitis, injection site reaction, and dupilumab facial redness. A 32-year-old female with severe atopic dermatitis was treated with dupilumab for 2 months at our clinic. She complained of multiple enlarged palpable lymph nodes on the right side of the neck and inguinal area for 2 months. Laboratory tests showed an increased total eosinophil count and immunoglobulin E level, as well as positive interferon-γ release assays. Radiological examination showed multiple low echoic and heterogeneous well-enhancing lymph nodes in level II, III, IV, and V of the neck. Histological examination revealed caseous necrosis and tuberculoid granuloma. The lymph node enlargements were completely relieved after anti-tuberculosis treatment. The mechanism for the development of tuberculous lymphadenitis in a patient receiving dupilumab is not fully understood yet. In some previous studies, treatment with dupilumab suppressed the expression of genes related not only to T helper 2 and eosinophil response but also to proinflammatory responses. It could not inhibit the intracellular growth of Mycobacterium tuberculosis in macrophages, predisposing them to the development of tuberculous infection. To the best of our knowledge, this is the first report on the development of tuberculosis lymphadenitis in a patient treated with dupilumab.