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( Do Hyun Kim ),( Myung Douk Ahn ) 대한안과학회 2012 Korean Journal of Ophthalmology Vol.26 No.3
Purpose: To evaluate the expression of the Na+-K+-2Cl--cotransporter 2 (NKCC2) in the ischemic rat retina. Methods: Retinal ischemia was induced by pressures 90 to 120 mmHg, above systemic systolic pressure. Immunohistochemistry and western blot analysis were performed. Results: NKCC2 is expressed in the normal retina and its expression is increased by ischemia caused by intraocular pressure elevation. NKCC2 immunoreactivity was observed mainly in axon bundles of ganglion cells and horizontal cell processes in the retina. NKCC2 expression continuously increased with a peak value 3 days (to 415% of normal levels) after ischemic injury, and then gradually decreased to 314% of controls until 2 weeks post injury. The mean density of NKCC2-labeled ganglion cells per mm2 changed from 1,255 ± 109 in normal retinas to 391 ± 49 and 185 ± 37 at 3 days and 2 weeks after ischemia, respectively ( p < 0.05), implying cell death of ganglion cells labeled with NKCC2. Conclusions: Taken together, these results suggest that NKCC2, which is expressed in retinal ganglion and horizontal cells, may contribute to cell death by ischemic injury in the retina, although the molecular mechanisms involved remain to be clarified.
Cases of Pseudophakic Pseudoexfoliation in Glaucoma Patients
( Hae Young Lopilly Park ),( Myung Douk Ahn ) 대한안과학회 2012 Korean Journal of Ophthalmology Vol.26 No.5
We present cases of primary open angle glaucoma patients without previous history of pseudoexfoliation who developed pseudoexfoliative materials on the anterior surface of the intraocular lens after cataract surgery. Among 5 unilateral pseudophakic pseudoexfoliation cases, 3 showed a more advanced state of glaucoma in the affected eye. The other 2 cases showed progression of glaucoma in the affected eye after the development of pseudophakic pseudoexfoliation, while the unaffected eyes remained stable. In the latter 2 cases, control of intraocular pressure was difficult, and more glaucoma medication was needed in the affected eye. Pseudophakic pseudoexfoliation in glaucoma patients with no history of pseudoexfoliation syndrome or pseudoexfoliative glaucoma has not been reported. In our cases, the eyes which developed pseudophakic pseudoexfoliation showed a more advanced state of glaucoma, more difficulty controlling intraocular pressure, and faster progression of glaucoma. More observation is needed, but we cautiously postulate that pseudophakic pseudoexfoliation may have a role as a clinical risk factor in the prediction of glaucoma progression.
Kim, Jae Ho,Ahn, Myung Douk CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
The aim of this study was to evaluate the degree of tolerance of the rabbit's eye when UNI-IOL manufactured in Korea was implanted into the rabbit's eye in comparison with that of the rabbit's eye when IOLAB-IOL manufactured in U. S. A. was implanted. Twenty two eyes of 22 rabbits were operated with extracapsular lens extraction using He-alon^? IOLAB-IOL was implanted into 11 eyes (Group 1) while UNI-IOL was implanted into another 11 eyes (Group 2). Clinical observation was performed for 5 months and corneal thickness and endothelial cell density were measured and ultrastructural changes were observed with light and electron microscopes. The results are as follows: 1. Clinical observation by slit lamp biomicroscope revealed that inflammatory reaction in the anterior chamber in both groups decreased gradually until postoperative 10th day and almost disappeared by the postoperative 14th day. 2. Comeal thickness of group 1 and 2 increased by 33.5% and 3 5.9% respectively on the postoperative 1st day and increased most on the 17.2% and 21.7% respectively on the postoperative 7th day. After 28 days after the operation it decreased to 5.5% and 7.7% and 5 months after the operation 1.3% and 2.11% which are almost normal levels. The change of corneal thickness was not significant statistically between group 1 and 2. 3. Decreasing rate of endothelial cell density in group 1 and 2 showed 20.2% and 22.7% on the postoperative 4th day, 5.3% and 5.2% on the postoperative 28th day, 2.8% and 2.7% after 3 months and after 5 months 1.5% and 1.3% respectively. The change of endothelial cell density was not significant statistically between group 1 and 2. 4. Light microscopic finding showed mild chronic inflammatory infiltrates in the stroma of iris and ciliary body in both groups. 5. Scanning electron microscopic finding showed normal hexagonal cell shape with some edema in both groups on the postoperative 14th day while both groups showed normal cell shape without edema 28 days, 3 montlis and 5 months after the operation. Transmission electron microscopic finding showed no changes in internal structure of endothelial cells in both groups. In conclusion, the implantation in rabbit's eyes of the UNI-IOL showed little difference in clinical and histopathologic findings compared with that of IOLAB-IOL, and was well tolerated.
정상안압녹내장 환자에서 혈액검사를 통한 전신적 인자에 대한 분석
이나영,안명덕,Na Young Lee,Myung Douk Ahn 대한안과학회 2010 대한안과학회지 Vol.51 No.2
Purpose: In this study, we evaluated systemic hemodynamic factors of normal tension glaucoma. Methods: Forty patients with normal tension glaucoma and thirty healthy people were investigated with regard to hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, triglycerides, LDL, HDL, and highsensitivity C-reactive protein (hsCRP). Also, ET-1 and MCP-1 were measured using enzyme-linked immunosorbent assay kits. Results: The results of the blood examinations showed no statistically significant differences in hemoglobin, hematocrit, RBC count, WBC count, platelet count, fasting glucose, HbA1c, total cholesterol, LDL, HDL, and hsCRP. Only triglycerides showed a statistically significant difference between the groups (P=0.03). The level of serum ET-1 was significantly higher in the normal tension glaucoma group (P=0.007). The results of MCP-1 showed no statistically significant difference. Conclusions: We conclude that normal tension glaucoma Is associated with an increased level of triglycerides and that the level of ET-1 could be a hemodynamic cause of normal tension glaucoma. J Korean Ophthalmol Soc 2010;51(2):241-247