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      저자 : ( Md Salman Hussain ) (검색결과 1 건)
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      • Positive association exists between abdominal obesity and asthma: Evidence from a meta-analysis of cohort studies

        ( Md Salman Hussain ),( Abul Kalam Najmi ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0

        Purpose: Asthma is the most common respiratory disease affecting more than 350 million people worldwide. Epidemiological studies found an association between asthma and abdominal obesity. However, the published evidence presented conflicting findings. So, this study is aimed to assess the association between abdominal obesity and asthma. Method: A Literature search was performed in databases including PubMed, and Embase from inception to July 2019. Two investigators independently retrieved the literature, extracted the data and assess the study quality using the Newcastle-Ottawa Scale. The primary outcome was to assess the association between abdominal obesity and asthma. Secondary outcomes include subgroup analysis based on gender. Review Manager version 5.3 was used for the statistical analysis. Results: This meta-analysis was based on five cohort studies with a total of 39533 patients. Included studies were of high quality. Abdominal obesity was assessed based on the waist circumference in all the included studies. The pooled analysis found a significant positive association between abdominal obesity and asthma with an odds ratio of 1.66 (95% CI: 1.30 - 2.15), p= <0.0001 (Fig.1). Subgroup analysis based on the female population found a significant positive association between abdominal obesity and asthma with a pooled odds ratio of 1.30 (95% CI: 1.04 - 1.63), p= 0.02. Whereas, a non-significant association exists when the data were pooled for the male population with an odds ratio of 1.66 (95% CI: 0.78 - 3.52), p= 0.19. Conclusion: We found a positive association between abdominal obesity and asthma. Future large epidemiological studies are warranted to make the evidence more robust.

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