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RISS 인기검색어
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- 저자 : ( Masayuki Kitagawa ) (검색결과 3 건)
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( Masayuki Kitagawa ),( Jiro Akiba ),( Yukihiro Shikama ),( Ikuro Ohta ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Advanced glycation end products such as carboxymethyl-lysine are produced by a nonenzymatic reaction between proteins and sugar in patients with long-term hyperglycemia. Advanced glycation end products in the matrix of the walls of small blood vessels are thought to have an effect on the development of diabetic complication. We hypothesized that plasma levels of caroxymethyl-lysine were re- flected by the severity of diabetic neuropathy. Methods: 1) Patients: The 84 patients with type 2 diabetes mellitus (mean age 61.8±9.5 years, duration of diabetes 12.4±8.6, mean HbA1c 7.7±1.4%) were included. 2) Carboxymethl-lysine: The plasma levels of carboxymethyl-lysine were measured by ELISA method. 3) Motor Nerve Conduction Velocity: We measured motor nerve conduction velocity of tibial nerve as marker of the severity of diabetic neuropathy. 4) Statistical Analyses: Correlation was assessed by linear regression analysis and multiple regression analysis using Stat View 5 for Macintosh. Results: In 53 type 2 diabetic patients with normal renal function (serum creatinine <1.0 mg/dl), we measured motor nerve conduction velocity of tibial nerve, and at the same time, we measured plasma levels of carboxymethyl-lysine. Motor nerve conduction velocity was correlated negatively with plasma levels of carboxymethyl-lysine in 25 male patients (r = 0.228, p = 0.29), but motor nerve conduction velocity was significantly correlated with plasma levels of carboxymethyl-lysine in 28 female patients (r =-0.632, p < 0.0003). Multiple regression analysis revealed an in dependent influence of plasma levels of carboxmethyl-lysine on motor nerve conduction velocity of tibial nerve in 28 female patients (r² = 0.375, p < 0.05). Conclusions: Our data suggests that plasma levels of carboxymethyl-lysine may be one of the etiology of diabetic neuropathy in female diabetic patients. We presumed this result is concerned with female lipid peroxidation of carboxymethyl-lysine.
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( Masayuki Kitagawa ),( Jiro Akiba ),( Yukihiro Shikama ),( Ikuro Ohta ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: It is thought that there is close relation in glucose metabolism and brain damage. It is presumed that brain damage is caused for hypoglycemia. A limbic system exists in the inside of the cerebral cortex. It has been reported that limbic system atrophy tends to receive damage with hypoglycemia. We evaluated brain MR imaging changes of limbic system in a patient with type 2 diabetes mellitus with hypoglycemia. This case was considered to be a precious case when considering the relevance of glucose metabolism and brain damage. Case Report: The patient was 86-year-old female diagnosed with type 2 diabetes mellitus 20 years ago. She was brought to the emergency department in our hospital due to consciousness disturbance. In the emergency room, the blood glucose level was 16 mg/dl, and consciousness disorder was not recovered although intravenous injection of glucose was performed. It was presumed that the badness of a general state and unsuitable use of the oral hypoglycemic agent caused unstable glycemic control. Evaluation of change of brain MRI was made for 98 days. Results: Evaluation of change of brain MRI was made for 98 days. The appearance of limbic system atrophy was observed. Limbic system atrophy advanced gradually. It was thought that this case was a precious case in which picture change of the limbic system was able to be caught. Conclusions: It is presumed that hypoglycemia brings about activation of a glutamic acid receptor, and causes oxidant stress, and it is presumed that they make brain damage induce. Also in this case, we thought the damage of the limbic system was based on hypoglycemia. This case was considered to be a precious case when considering the relevance of glucose metabolism and brain damage.
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Realization of Mobility-Controlled Flying Router in Information-Centric Networking
Yuhao Gao,Taku Kitagawa,Suyong Eum,Shingo Ata,Masayuki Murata 한국통신학회 2018 Journal of communications and networks Vol.20 No.5
Constructing a large-scale network in outdoor fieldswith wired or wireless antennas involves a huge deployment cost. New devices, called movable routers, are able to realize the networksat a low cost. Recently, a large number of internet of thingsnodes have been deployed into the networks in outdoor fields. Inthe current communication network, users intend to communicatewith devices without knowing where they are, but the currentnetwork still focuses on device locations, complicating configurationand implementation of the network. In this study, we designan architecture called router-movable information-centric networking(RMICN) to realize content-based communication insteadof host-based communication, for facilitating communications betweendisjointed networks using movable routers. We incorporateinformation-centric networking technologies in the design of thesystem for the naming scheme and the strategy layer, enabling devicecontrol over the movable routers, called flying routers. In thesimulation results, we show that RMICN can further reduce the responsetime of content requests compared with delay-tolerant networking. Furthermore, we present a proof-of-concept implementationof the architecture to confirm the feasibility of the design.
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