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유동층 1 : H-14 ; Development of Coumarin Modified Si-MCM-41 for Drug Delivery System
이태규,( Manickam Selvaraj ),김병후,민병렬 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.2
The mesoporous Si-MCM-41 molecular sieves using different surfactant for different pore sizes have been synthesized under hydrothermal conditions. The materials were modified by coumarin derivatives for the properties of hinged double doors (either pore size closed). The surfactants were removed from the synthesized Si-MCM-41 using dilute hydrochloric acid under extraction method. The materials have been used for absorption and released of drug as ibuprofen under photo-irradiation. The ibuprofen absorbed by the mesoporous materials when the coumarin dimersed within pores while the ibuprofen released slowly from the materials when the dimersed coumarin was cleavaged under photo-irradiation conditions. The materials results and absorbed-released results will be presented.
Vanitha, Manickam Kalappan,Priya, Kalpana Deepa,Baskaran, Kuppusamy,Periyasamy, Kuppusamy,Saravanan, Dhravidamani,Venkateswari, Ramachandran,Mani, Balasundaram Revathi,Ilakkia, Aruldass,Selvaraj, Sund KOREAN PHARMACOPUNCTURE INSTITUTE 2015 Journal of pharmacopuncture Vol.18 No.3
Objectives: The present study was undertaken to determine the modulatory effect of taurine on the liver mitochondrial enzyme system with reference to mitochondrial lipid peroxidation (LPO), antioxidants, major tricarboxylic acid cycle enzymes, and electron transport chain enzymes during 7,12-dimethyl benz[a]anthracene (DMBA) induced breast cancer in Sprague-Dawley rats. Methods: Animals in which breast cancer had been induced by using DMBA (25 mg/kg body weight) showed an increase in mitochondrial LPO together with decreases in enzymic antioxidants (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione-S-transferase (GST)), non-enzymic antioxidants (reduced glutathione (GSH), vitamin C, and vitamin E), in citric acid cycle enzymes (isocitrate dehydrogenase (ICDH), alpha ketoglutarate dehydrogenase (alpha KDH), succinate dehydrogenase (SDH) and malate dehydrogenase (MDH)), and in electron transport chain (ETC) complexes. Results: Taurine (100 mg/kg body weight) treatment decreased liver mitochondrial LPO and augmented the activities/levels of enzymic, and non-enzymic antioxidants, tricarboxylic acid cycle enzymes and ETC complexes. Conclusion: The results of our present study demonstrated the chemotherapeutic efficacy of taurine treatment for DMBA-induced breast carcinomas.
H-12 : Synthesis and Characterization of Si-MCM-41 by Different Acid Medium
김병후,이태규,( Manickam Selvaraj ),박진원 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.2
The mesoporous MCM-41 molecular sieves are synthesized by self-assembly of silicasurfactant in which inorganic species simultaneously condense, giving rise to mesoscopically ordered composites formation. The mesoporous Si-MCM-41 materials have been synthesized using sodium metasilicate as silica source and cetyltrimethylammonium bromide as template under hydrothermal conditions. The as-synthesized Si-MCM-41 have been also modified by 3-aminopropyltriethoxysilane for pore modification. The materials have been characterized by XRD, FT-IR, SEM, TEM and N2-adsorption for the proof of mesoporous, thermal stability, template removal, pore size, pore volume, surface area, environments of silanol group, morphology and uniform pore size.
Ravi, Seenu,Selvaraj, Manickam,Park, Hyun,Chun, Ho-Hwan,Ha, Chang-Sik The Royal Society of Chemistry 2014 NEW JOURNAL OF CHEMISTRY Vol.38 No.8
<P>Novel hierarchically dispersed spherical mesoporous silica (HSMS) was synthesized using a surfactant mixture of fluorocarbon (FC-4), cetyl-trimethyl ammonium bromide (CTAB), and block copolymer Pluronic F127 (PF127). To prepare the thiol-functionalized HSMS (T-HSMS), the synthesized HSMS was functionalized by a co-condensation method using 3-mercaptotrimethoxysilane (3-MPS) as a thiol reagent. The obtained HSMS and T-HSMS possess a cubic morphology with a <I>lm</I>3&cmb.macr;<I>m</I> space group and a particle diameter of 75–200 nm. The HSMS and T-HSMS materials exhibit large free surface areas exceeding 844 and 663 m<SUP>2</SUP> g<SUP>−1</SUP> and pore radii of approximately 3.2 and 3.1 nm, respectively. The synthesized materials were characterized using small angle X-ray scattering, N<SUB>2</SUB>-physisorption studies, scanning electron microscopy, transmission electron microscopy, and Fourier transform infrared spectroscopy studies. The efficacy of mercury adsorption by T-HSMS was studied at different temperatures, 283, 298, and 313 K. The obtained results were fitted with a Langmuir adsorption isothermal plot. The changes in the negative Gibbs free energy values for the spontaneity of the process were calculated. Mercury could be successfully desorbed using thiourea in a 2 M HCl solution, and the adsorbents could be subsequently reused without severe loss of their activity after repeated adsorption tests.</P> <P>Graphic Abstract</P><P>Hierarchically dispersed spherical mesoporous silica (HSMS) was easily synthesized using three surfactants (CTAB, PF127 and FC-4). This is then successfully modified with thiol groups and used for mercury adsorption studies. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4nj00418c'> </P>