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Kang, Kkot Nim,Lee, Ju Young,Kim, Da Yeon,Lee, Bit Na,Ahn, Hyun Hee,Lee, Bong,Khang, Gilson,Park, So Ra,Min, Byoung Hyun,Kim, Jae Ho,Lee, Hai Bang,Kim, Moon Suk Mary Ann Liebert 2011 Tissue engineering. Part A Vol.17 No.17
<P>Using a complete spinal cord transection model, the present study employed a combinatorial strategy comprising rat bone marrow stem cells (rBMSCs) and polymer scaffolds to regenerate neurological function after spinal cord injury (SCI) of different lengths. SCI models with completely transected lesions were prepared by surgical removal of 1?mm (SC1) or 3?mm (SC3) lengths of spinal cord in the eighth-to-ninth spinal vertebrae, a procedure that resulted in bilateral hindlimb paralysis. A cylindrical poly(D,L-lactide-co-glycolide)/small intestinal submucosa scaffold 1 or 3?mm in length with or without rBMSCs was fitted into the completely transected lesion. Rats in SC1 and SC3 groups implanted with rBMSC-containing scaffolds received Basso-Beattie-Bresnahan scores for hindlimb locomotion of 15 and 8, respectively, compared with 3 for control rats in SC1-C and SC3-C groups implanted with scaffolds lacking rBMSCs. The amplitude of motor-evoked potentials recorded in the hindlimb area of the sensorimotor cortex after stimulation of the injured spinal cord averaged 100?μV in SC1-C and 10-50?μV in SC3-C groups at 4 weeks, and then declined to nearly zero at 8 weeks. In contrast, the amplitude of motor-evoked potentials increased from 300 to 350?μV between 4 and 8 weeks in SC1 rats and from 200 to 250?μV in SC3 rats. These results demonstrate functional recovery in rBMSC-transplanted rats, especially those with smaller defects. Immunohistochemically stained sections of the injury site showed clear evidence for axonal regeneration only in rBMSC-transplanted SC1 and SC3 models. In addition, rBMSCs were detected at the implanted site 4 and 8 weeks after transplantation, indicating cell survival in SCI. Collectively, our results indicate that therapeutic rBMSCs in a poly(D,L-lactide-co-glycolide)/small intestinal submucosa scaffold induced nerve regeneration in a complete spinal cord transection model and showed that functional recovery further depended on defect length.</P>
<i>In Vivo</i> Biocompatibility Study of Electrospun Chitosan Microfiber for Tissue Engineering
Kang, Yun Mi,Lee, Bit Na,Ko, Jae Hoon,Kim, Gyeong Hae,Kang, Kkot Nim,Kim, Da Yeon,Kim, Jae Ho,Park, Young Hwan,Chun, Heung Jae,Kim, Chun Ho,Kim, Moon Suk Molecular Diversity Preservation International (MD 2010 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.11 No.10
<P>In this work, we examined the biocompatibility of electrospun chitosan microfibers as a scaffold. The chitosan microfibers showed a three-dimensional pore structure by SEM. The chitosan microfibers supported attachment and viability of rat muscle-derived stem cells (rMDSCs). Subcutaneous implantation of the chitosan microfibers demonstrated that implantation of rMDSCs containing chitosan microfibers induced lower host tissue responses with decreased macrophage accumulation than did the chitosan microfibers alone, probably due to the immunosuppression of the transplanted rMDSCs. Our results collectively show that chitosan microfibers could serve as a biocompatible <I>in vivo</I> scaffold for rMDSCs in rats.</P>
Potential induction of rat muscle-derived stem cells to neural-like cells by retinoic acid
Kim, E Sle,Kim, Gyeong Hae,Kang, Mi Lan,Kang, Yun Mi,Kang, Kkot Nim,Hwang, Ki Chul,Min, Byoung Hyun,Kim, Jae Ho,Kim, Moon Suk Wiley (John WileySons) 2011 JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MED Vol.5 No.5
Feature Article : Wound Dressings for Wound Healing and Drug Delivery
( Gyeong Hae Kim ),( Yun Mi Kang ),( Kkot Nim Kang ),( Da Yeon Kim ),( Hyun Jung Kim ),( Byung Hyun Min ),( Jae Ho Kim ),( Moon Suk Kim ) 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.1
Since skin is what protects our body from the external environment, skin wounds cause inconveniences in life and lead to post-trauma sequela and stress. When the skin is wounded, it is healed through a series of pro-cesses, such as via the haemostasis/inflammation phase, migration phase, proliferation phase, and maturation phase, during which time exudate containing various growth factors is released at the wound. Wound dressings we reemployed by dry dressing in the past, and this process heals the wound by drying it and creating crust, but, recently, wet dressings have been used in locations where appropriate temperature and humidity are maintained. Also, besides wet dressings, drug delivery systems and tissue engineering have been used recently for wound treatment, both of which utilize wound dressing products, such as hydrocolloid, alginate, hydrogel, foam, and biological dressings. And now, reaching beyond the existing role of just protecting the wound, wound dressings for drug delivery systems con-taining drugs and growth factors are being researched so that they can be used for difficult wound treatments, suchas chronic wounds or burns. This article reviews the developments of various wound dressings that have been madeto date.
Toxicity Evaluation of Rat Muscle-Derived Stem Cells by Galantamine
( E Sle Kim ),( Gyeong Hae Kim ),( Mi Lan Kang ),( Yun Mi Kang ),( Kkot Nim Kang ),( Jae Hyeok Lee ),( Byoung Hyun Min ),( Jae Ho Kim ),( Moon Suk Kim ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.3
Muscle-derived stem cells (MDSCs) can be differentiated into various types of cells. In this research, toxicity evaluation of MDSCs with galantamine (Gal) used to treat neurological diseases was first conducted for rat MDSCs. MDSCs treated with Gal showed that cytoplasm condensed around the nucleus and stretched out the dendrites from the nucleus. Compared to the control group and the positive control group, it is confirmed that Gal possesses toxicity. In the toxicity evaluation of cells in different chemical concentrations, it was found that the group treated with Gal showed relatively low toxicity after 1 day and high those after 4 days, but as time went by, it was confirmed that the proliferation of cells was well accomplished.