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RISS 인기검색어
- 검색키워드
- 저자 : ( Kamran Bagheri Lankarani ) (검색결과 2 건)
- 무료
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Pathophysiological role of Atg5 in human ulcerative colitis
( Razieh Ardali ),( Nasrin Kazemipour ),( Saeed Nazifi ),( Kamran Bagheri Lankarani ),( Iman Razeghian Jahromi ),( Masood Sepehrimanesh ) 대한장연구학회 2020 Intestinal Research Vol.18 No.4
Background/Aims: Ulcerative colitis (UC), along with Crohn’s disease, is one of the main types of inflammatory bowel disease (IBD). On the other hand, deregulated autophagy is involved in many chronic diseases, including IBD. In this study, we aimed to investigate the role of Atg5 and microRNA-181a (miR-181a) in the pathophysiology of UC. Methods: Colon biopsy, stool, and blood samples of 6 men and 9 women were confirmed for UC. Also, 13 men and 17 women were selected as healthy control (HC). Enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry were used to measure the Atg-5 content of the colon biopsies. Besides, the serum and stool levels of Atg5 were measured using ELISA. Moreover, the total RNA of blood cells was extracted and evaluated for the expression of miR-181a. Results: We found 1.2 ng/mL versus 0.46 ng/mL, 0.34 ng/mL versus 0.24 ng/mL, and 0.082 ng/mL versus 0.062 ng/mL of Atg5 in stool, intestinal tissue, and serum of UC and HCs, respec tively. There was no significant difference in the expression of miR-181a in the blood samples of UC and HCs. Immunohisto chemistry showed high positivity without any significant difference between the 2 groups in the quantitative analysis. Conclu sions: The significant difference observed between the stool Atg5 content of the HCs and UC patients may provide new insight into using this protein as a diagnostic biomarker, however, considering the small size of our studied population further studies are needed. (Intest Res 2020;18:421-429)
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Lipid Profiles and Hepatitis C Viral Markers in HCV-Infected Thalassemic Patients
( Seyed Moayed Alavian ),( Seyyed Mohammad Miri ),( Seyed Vahid Tabatabaei ),( Maryam Keshvari ),( Bita Behnava ),( Pegah Karimi Elizee ),( Nastaran Mahboobi ),( Kamran Bagheri Lankarani ) 대한소화기기능성질환·운동학회 2011 Gut and Liver Vol.5 No.3
Background/Aims: The distribution of blood lipids, glucose and their determinants in thalassemic patients with chronic hepatitis C virus (HCV) infection has rarely been investigated. Thus, we aimed to investigate the relationship between both liver histologic findings and viral markers and serum lipids in thalassemic patients chronically infected with HCV. Methods: We enrolled 280 polytransfused thalassemic patients with chronic hepatitis C. HCV viral load was determined using the Amplicor test. Genotyping was performed using genotype specific primers. Fasting serum lipid, glucose, ferritin and liver function enzyme concentrations were measured. A modified Knodell scoring system was used to stage liver fibrosis and to grade necroinflammatory activity. Perls` staining was used to assess hepatic siderosis. Results: Just one subject had total cholesterol >200 mg/dL, and 7% had triglycerides >150 mg/dL. The mean high-density lipoprotein cholesterol (HDL-C) and glucose levels were 37 and 104 (97-111) mg/dL, respectively. Viral markers, liver histological findings and aminotransferase activity were not associated with serum lipid levels. Serum triglycerides, total cholesterol and ferritin were independent risk factors for impaired glucose tolerance or diabetes in these patients. Conclusions: The majority of the patients had blood lipid levels (with the exception of HDL) within the defined normal range; viral and liver histological factors do not appear to play a significant role in changing the levels of serum lipids or glucose in these patients. (Gut Liver 2011;5:348-355)
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