http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ban, Jung Ok,Lee, Hee Soon,Jeong, Heon-Sang,Song, Sugkil,Hwang, Bang Yeon,Moon, Dong Cheul,Yoon, Do Young,Han, Sang Bae,Hong, Jin Tae American Association for Cancer Research 2009 Molecular Cancer Research Vol.7 No.6
<P>Chemotherapeutic strategies commonly use multiple agents to overcome drug resistance and to lower drug toxicity. Activation of nuclear factor-kappaB (NF-kappaB) is implicated in drug resistance in cancer cells. Previously, we reported that thiacremonone, a novel sulfur compound isolated from garlic, inhibited NF-kappaB and cancer cell growth with IC(50) values about 100 microg/mL in colon cancer cells. In the present study, we tested whether thiacremonone could increase susceptibility of cancer cells to chemotherapeutics through inactivation of NF-kappaB. Colon cancer cells were cotreated with thiacremonone (50 microg/mL, half dose of IC(50)) and lower doses of each chemotherapeutic agent (half dose of IC(50)) for 24 hours. NF-kappaB activity was completely abrogated in cells treated with a combination of thiacremonone and docetaxel, whereas thiacremonone on its own did not alter NF-kappaB activity. This combined drug effect was also found with other anticancer drugs in colon cancer and in other cancer cells. In good correlation with inhibition of cell growth and NF-kappaB activity, the combination treatment also regulated NF-kappaB target genes. Oral treatment of mice with thiacremonone (1 mg/kg) by administering it in drinking water for 4 weeks significantly augmented docetaxel (1 mg/kg, i.p., four times)-induced decrease of tumor growth accompanied with regulation of NF-kappaB activity and NF-kappaB target genes. These results warrant carefully designed clinical studies investigating the combination of thiacremonone and commonly used chemotherapeutic agents for the treatment of human cancers.</P>
Ban, Jung Ok,Oh, Ju Hoon,Kim, Tae Myoung,Kim, Dae Joong,Jeong, Heon-Sang,Han, Sang Bae,Hong, Jin Tae BioMed Central 2009 ARTHRITIS RESEARCH AND THERAPY Vol.11 No.5
<P><B>Introduction</B></P><P>Sulfur compounds isolated from garlic exert anti-inflammatory properties. We recently isolated thiacremonone, a novel sulfur compound from garlic. Here, we investigated the anti-inflammatory and arthritis properties of thiacremonone through inhibition of NF-κB since NF-κB is known to be a target molecule of sulfur compounds and an implicated transcription factor regulating inflammatory response genes.</P><P><B>Methods</B></P><P>The anti-inflammatory and arthritis effects of thiacremone in <I>in vivo </I>were investigated in 12-O-tetradecanoylphorbol-13-acetate-induced ear edema, carrageenan and mycobacterium butyricum-induced inflammatory and arthritis models. Lipopolysaccharide-induced nitric oxide (NO) production was determined by Griess method. The DNA binding activity of NF-κB was investigated by electrophoretic mobility shift assay. NF-κB and inducible nitric oxide synthetase (iNOS) transcriptional activity was determined by luciferase assay. Expression of iNOS and cyclooxygenase-2 (COX-2) was determined by western blot.</P><P><B>Results</B></P><P>The results showed that topical application of thiacremonone (1 or 2 μg/ear) suppressed the 12-O-tetradecanoylphorbol-13-acetate-induced (1 μg/ear) ear edema. Thiacremonone (1-10 mg/kg) administered directly into the plantar surface of hind paw also suppressed the carrageenan (1.5 mg/paw) and mycobacterium butyricum (2 mg/paw)-induced inflammatory and arthritic responses as well as expression of iNOS and COX-2, in addition to NF-κB DNA-binding activity. In further in vitro study, thiacremonone (2.5-10 μg/ml) inhibited lipopolysaccharide (LPS, 1 μg/ml)-induced nitric oxide (NO) production, and NF-κB transcriptional and DNA binding activity in a dose dependent manner. The inhibition of NO by thiacremonone was consistent with the inhibitory effect on LPS-induced inducible nitric oxide synthase (iNOS) and COX-2 expression, as well as iNOS transcriptional activity. Moreover, thiacremonone inhibited LPS-induced p50 and p65 nuclear translocation, resulting in an inhibition of the DNA binding activity of the NF-κB. These inhibitory effects on NF-κB activity and NO generation were suppressed by reducing agents dithiothreitol (DTT) and glutathione, and were abrogated in p50 (C62S)-mutant cells, suggesting that the sulfhydryl group of NF-κB molecules may be a target of thiacremonone.</P><P><B>Conclusions</B></P><P>The present results suggested that thiacremonone exerted its anti-inflammatory and anti-arthritic properties through the inhibition of NF-κB activation via interaction with the sulfhydryl group of NF-κB molecules, and thus could be a useful agent for the treatment of inflammatory and arthritic diseases.</P>
Ban, Jung Ok,Oh, Ju Hoon,Hwang, Bang Yeon,Moon, Dong Cheul,Jeong, Heon-Sang,Lee, Seram,Kim, Soyoun,Lee, Hyosung,Kim, Kyung-Bo,Han, Sang Bae,Hong, Jin Tae American Association for Cancer Research, Inc 2009 Molecular Cancer Therapeutics Vol.8 No.6
<P>Kaurane diterpene compounds have been known to be cytotoxic against several cancer cells through inhibition of nuclear factor-kappaB (NF-kappaB) activity. Here, we showed that inflexinol, a novel kaurane diterpene compound, inhibited the activity of NF-kappaB and its target gene expression as well as cancer cell growth through induction of apoptotic cell death in vitro and in vivo. These inhibitory effects on NF-kappaB activity and on cancer cell growth were suppressed by the reducing agents DTT and glutathione and were abrogated in the cells transfected with mutant p50 (C62S). Sol-gel biochip and surface plasmon resonance analysis showed that inflexinol binds to the p50 subunit of NF-kappaB. These results suggest that inflexinol inhibits colon cancer cell growth via induction of apoptotic cell death through inactivation of NF-kappaB by a direct modification of cysteine residue in the p50 subunit of NF-kappaB.</P>
Ban, Jung Ok,Kim, Dae Hwan,Lee, Hee Pom,Hwang, Chul Ju,Shim, Jung-Hyun,Kim, Dae Joong,Kim, Tae Myoung,Jeong, Heon-Sang,Nah, Seong Su,Chen, Hanyong,Dong, Zigang,Ham, Young Wan,Kim, Youngsoo,Han, Sang-B Wiley (Blackwell Publishing) 2014 British journal of pharmacology Vol.171 No.11
<P>Products of Maillard reactions between aminoacids and reducing sugars are known to have anti-inflammatory properties. Here we have assessed the anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal and its possible mechanisms of action.</P>
Ban, Jung-Ok,Hwang, In-Guk,Kim, Tae-Myoung,Hwang, Bang-Yeon,Lee, Ung-Soo,Jeong, Heon-Sang,Yoon, Young-Won,Kim, Dae-Joong,Hong, Jin-Tae 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11
Many natural compounds have been shown to prevent cancer cell growth through the redox regulation of transcription factors. $NF-{\kappa}B$, a redox transcription factor, has been implicated in the apoptotic cell death of several cancer cells. This study examined whether or nor 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyranone (DDMP) isolated from onions can modulate the activity of $NF-{\kappa}B$, thereby induce the apoptotic cell death of colon cancer cells. Treatment with different DDMP concentrations (0.5-1.5 mg/mL) for various periods (0-48 h) inhibited the growth of colon cancer cells (SW620 and HCT116) followed by the induction of apoptosis in a dose dependent manner. It was also found that DDMP modulated tumor necrosis $factor-{\alpha}(TNF-{\alpha})$ and tetradeanoyl phorbol acetate (TPA)-induced $NF-{\kappa}B$ transcriptional and DNA binding activity. Moreover, DDMP suppressed the $NF-{\kappa}B$ target anti-apoptotic genes (Bcl-2), whereas it induced the expression of the apoptotic genes (Bax, cleaved caspase-3 and cleaved PARP). These results suggest that DDMP from onions inhibit colon cancer cell growth by inducing apoptotic cell death through the inhibition of $NF-{\kappa}B$.