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RISS 인기검색어
- 검색키워드
- 저자 : ( Jean Paul Ortonne ) (검색결과 2 건)
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What Should Be Considered in Treatment of Melasma
( Hee Young Kang ),( Jean Paul Ortonne ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.4
Melasma is a common acquired hyperpigmentary skin disorder characterized by light to dark brown macules and patches occurring in the sun-exposed areas of the face. Melasma lesional skin is characterized by epidermal hyperpigmentation through increased melanogenesis in epidermal melanocytes. Some patients have dermal melanin but its amount is not significant and its distribution is very heterogeneous in the whole melasma lesional skin. Melasma is not homogeneous disease and there are personal characteristics of patients with melasma. The pathogenesis of melasma is not fully understood, but several hypotheses have been suggested. Increased vascularity in melasma lesions has suggested the role of increased number of enlarged vessels in the development of melasma. Endogeneous and exogeneous stimuli such as sex hormones and ultraviolet irradiation respectively may stimulate the microenvironment leading to the release of various mediators that cause activation of melanocytes and/or these stimuli may directly activate the melanocytes. Melasma patients may have specialized melanocytes with an intrinsic sensitivity to these stimuli. (Ann Dermatol 22(4) 373~378, 2010)
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( Mi Sun Kim ),( Tae Jun Park ),( Ji Youn Park ),( Hye Ran Kim ),( Sun Yi Park ),( Kyoung Chan Park ),( Jean Paul Ortonne ),( Hee Young Kang ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Wnt signaling plays a role in the differentiation as well as the development of melanocytes. Using a microarray analysis, hyperpigmentary skin of melasma expressed high levels of Wnt inhibitory factor-1 (WIF-1) compared to perilesional normal skin. Objectives: In this study, we investigated the expression and functional role of WIF-1 in melanocytes. Methods: The expressions and fuctions of WIF-1 were assessed by Immunohistochemical staining, RT-PCR, western blot analysis, and immunocytochemical staining. Using a lentivirus system, WIF-1 was overexpressed in normal human melanocytes. siRNA system was used for WIF-1 downregulation. Ex vivo skin organ culture and promoter analysis were performed. Results: WIF-1 was expressed in both the melanocytes of normal human skin and in cultured melanocytes. The upregulation of WIF-1 on cultured normal human melanocytes significantly induced expressions of MITF and tyrosinase, which were associated with increased melanin content and tyrosinase activity. Consistent with the stimulatory effect of WIF-1, WIF-1 siRNA reduced melanogenesis in the cells. Moreover, WIF-1 increases pigmentation in melanocytes co-cultured with WIF-1 overexpressed fibroblasts and of organ-cultured human skin. Conclusion: These findings suggest that melanocytes express WIF-1 constitutively in vivo and in vitro and that WIF-1 promotes melanogenesis in normal human melanocytes. WIF-1 may have a role of increased melanogenesis in melanocytes of melasma skin.
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