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- 저자 : ( Imam Subekti ) (검색결과 2 건)
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( Gemalasari Novita Liman ),( Imam Subekti ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Diabetic nephropathy is found in 20%-40% of diabetic patients who are mostly type 2 diabetes. Research fi nding out the effectiveness of angiotensin-converting enzyme inhibitor (ACEI) for reducing microalbuminuria incident in type 2 diabetic patient with normoalbuminuria have been published. This evidence based case report (EBCR) will show the search and critical appraisal of those studies. Methods: The search of evidence was done in Pubmed and Cochrane Library database using keywords. After applying inclusion and exclusion criteria, fi ltering doubles, reading abstract and looking for full text availability: there were two remaining journals which were appraised based on standardized British Medical Journal criteria of validity, importance, and applicability. Results: Of the two meta-analysis, Article written by Hirst JA et al. is valid, important, and applicative for patient`s case. Meanwhile, article written by Vejakama P et al. is valid, but not important and applicative because of studies` heternogenity Conclusions: ACEI reduced microalbuminuria incident by 16% signifi cantly over placebo for type 2 diabetic patients with normoalbuminuria.
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Jen Fuk Liem,Dwi A. Suryandari,Safarina G. Malik,Muchtaruddin Mansyur,Dewi S. Soemarko,Aria Kekalih,Imam Subekti,Franciscus D. Suyatna,Bertha Pangaribuan 대한예방의학회 2022 예방의학회지 Vol.55 No.3
Objectives: One of the most widely used pesticides today is chlorpyrifos (CPF). Cytochrome P450 (CYP)2B6, the most prominent catalyst in CPF bioactivation, is highly polymorphic. The objective of our study was to evaluate the role of CYP2B6*6, which contains both 516G>T and 785A>G polymorphisms, in CPF toxicity, as represented by the concentration of 3,5,6-trichloro-2-pyridinol (TCPy), among vegetable farmers in Central Java, Indonesia, where CPF has been commonly used. Methods: A cross-sectional study was conducted among 132 vegetable farmers. Individual socio-demographic and occupational characteristics, as determinants of TCPy levels, were obtained using a structured interviewer-administered questionnaire and subsequently used to estimate the cumulative exposure level (CEL). TCPy levels were detected with liquid chromatography-mass spectrometry. CYP2B6*6 gene polymorphisms were analyzed using a TaqMan® SNP Genotyping Assay and Sanger sequencing. Linear regression analysis was performed to analyze the association between TCPy, as a biomarker of CPF exposure, and its determinants. Results: The prevalence of CYP2B6*6 polymorphisms was 31% for *1/*1, 51% for *1/*6, and 18% for *6/*6. TCPy concentrations were higher among participants with CYP2B6*1/*1 than among those with *1/*6 or *6/*6 genotypes. CYP2B6*6 gene polymorphisms, smoking, CEL, body mass index, and spraying time were retained in the final linear regression model as determinants of TCPy. Conclusions: The results suggest that CYP2B6*6 gene polymorphisms may play an important role in influencing susceptibility to CPF exposure. CYP2B6*6 gene polymorphisms together with CEL, smoking habits, body mass index, and spraying time were the determinants of urinary TCPy concentrations, as a biomarker of CPF toxicity.
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