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Evaluation of Biological Performance in a Newly Developed Single-use Bioreactor, the CELBIC System
Hyunwoo KIM,Rock Ki KIM,Young Hee SHIN,Yeong Ok BAIK,Sun Young KIM,Chong Myong KIM,Yong Bok LEE,Kyung Nam KIM,Duk Jae OH 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Since the SUB(Single-Use Bioreactor)s have several advantages compared with the conventional stainless steel-based bioreactors, such as flexibility in scale, low risk of contamination, reduced labors for cleaning/ sterilization, and validation/regulation issues, the usage of SUBs for cell culture has been increasing continuously, as the bioindustry of biopharmaceuticals (proteins, antibodies, cell therapies and gene therapies products) has expanded dramatically during recent decades. In this study, a newly developed cell culture system, the CELBIC system, driven by multi-directional rocking movement is introduced and evaluated its physical and biological performances as a cell culture device. Three recombinant cell lines, CHO DG44, CHO-S, and CHO-K1, producing proteins were used for experiments, and cell cultures were carried out in four different working volumes of 1 liter, 5 liters, 50 liters, and 250 liters. Those cell cultures as the biological evaluation were performed under the conditions chosen from the results of evaluation of physical performances of the CELBIC system. For comparison, Erlenmeyer flasks and STR bioreactors representing a conventional cell culture device were used as control groups. Productivity was analyzed through ELISA and HPLC analysis methods. In the CELBIC system, cell cultures could be carried out successfully. In addition, cell growth performances were equal or superior to those of the control groups. From the results of biological evaluation, it was found that the CELBIC system is a SUB system easy to scale-up and able to cultivate cells specialized in suspension culture for producing proteins. It is considered that the CELBIC system can be an appealing alternative as a culture device across the biopharmaceutical fields including research and industry.
Dendritic Cell Dysfunction in Patients with End-stage Renal Disease
Kim, Ji Ung,Kim, Miyeon,Kim, Sinae,Nguyen, Tam Thanh,Kim, Eunhye,Lee, Siyoung,Kim, Soohyun,Kim, Hyunwoo 한국조명·전기설비학회 2017 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>End-stage renal disease (ESRD) with immune disorder involves complex interactions between the innate and adaptive immune responses. ESRD is associated with various alterations in immune function such as a reduction in polymorphonuclear leukocyte bactericidal activity, a suppression of lymphocyte proliferative response to stimuli, and a malfunction of cell-mediated immunity at the molecular level. ESRD also increases patients' propensity for infections and malignancies as well as causing a diminished response to vaccination. Several factors influence the immunodeficiency in patients with ESRD, including uremic toxins, malnutrition, chronic inflammation, and the therapeutic dialysis modality. The alteration of T-cell function in ESRD has been considered to be a major factor underlying the impaired adaptive cellular immunity in these patients. However, cumulative evidence has suggested that the immune defect in ESRD can be caused by an Ag-presenting dendritic cell (DC) dysfunction in addition to a T-cell defect. It has been reported that ESRD has a deleterious effect on DCs both in terms of their number and function, although the precise mechanism by which DC function becomes altered in these patients is unclear. In this review, we discuss the effects of ESRD on the number and function of DCs and propose a possible molecular mechanism for DC dysfunction. We also address therapeutic approaches to improve immune function by optimally activating DCs in patients with ESRD.</P>
Kim, Yukyung,Kim, Saerona,Noh, Seonmyeong,Kim, Semin,Park, Geunsu,Le, Thanh-Hai,Han, Hyunwoo,Kim, Yoong Ahm,Yoon, Hyeonseok Elsevier 2018 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.353 No.-
<P><B>Abstract</B></P> <P>A non-covalent approach to prepare nanotube-containing gels was developed based on the physical gelation of two polymers, polyvinyl alcohol (PVA) and polyacrylonitrile (PAN), with different microphase behaviors in water/dimethyl sulfoxide (DMSO) mixture. Single-walled carbon nanotubes (SWNTs) were incorporated into the binary-polymer/binary-solvent system to alter the physical gelation behavior and, in turn, to achieve unique physicochemical characteristics of the resulting gels. SWNTs were wrapped with PVA, which extended the binary polymer system to a ternary polymer system consisting of PVA bound to SWNTs, free PVA, and PAN. It was observed that the SWNT/PVA/PAN ensembles gelled with appropriate amounts of water in DMSO and the gelation behavior was reversible. The amounts of water and SWNT were determined to be key parameters affecting the formation of the gels. The SWNT/PVA/PAN gels were successfully converted to carbonaceous gels via heat treatment in an inert atmosphere, which can be extended to several applications such as electrode materials. The macroporous carbonaceous gels were further functionalized via manganese deposition followed by potassium hydroxide activation, which yielded excellent cell performance in a neutral electrolyte with the energy density of 9.6–24.8 Wh kg<SUP>−1</SUP> and power density of 8.0–0.1 kW kg<SUP>−1</SUP>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The effect of co-nonsolvents on the microstructure of the gel was demonstrated. </LI> <LI> The SWNT-mediated physical gelation of binary polymer blends were reported. </LI> <LI> Physically cross-linked gels were converted to versatile electrode materials. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Direct observation of pseudocapacitive sodium storage behavior in molybdenum dioxide anodes
Kim, Hyunchul,Son, Suhan,Choi, Woon Ih,Park, Gwi Ok,Kim, Yunok,Kim, Hyunwoo,Jeong, Mihee,Lee, Hyo Sug,Kim, Ji Man,Yoon, Won-Sub Elsevier 2018 Journal of Power Sources Vol.397 No.-
<P><B>Abstract</B></P> <P>Compared to research progress on cathode materials, progress on anode materials for sodium rechargeable batteries has been relatively slow. To bring sodium rechargeable batteries to a next level, it is necessary to explore feasible anode materials as well as understand clearly the reaction mechanism during electrochemical cycling. We herein introduce mesoporous and bulk molybdenum dioxide materials, which show excellent sodium storage performances under ether based electrolyte conditions, as anodes for sodium rechargeable batteries. Moreover, the pseudocapacitive sodium storage behavior in molybdenum dioxide anodes is proposed based on a quantitative analysis of the cyclic voltammetry responses. This result is systematically corroborated by using synchrotron radiation based analyses, X-ray photoelectron spectroscopy, scanning transmission electron microscope and <I>ab initio</I> molecular dynamics simulation. Comprehensive information on the electrochemical characterization as well as sodium storage mechanism of this transition metal oxide will provide a practical strategy to further advance anode materials for sodium rechargeable batteries.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Introducing mesoporous and bulk MoO<SUB>2</SUB> anodes for sodium ion batteries. </LI> <LI> Excellent electrochemical performances using DME electrolyte. </LI> <LI> Pseudocapacitive sodium storage behavior is proposed based on CV measurements. </LI> <LI> Systematic validation by diverse structural analysis tools along with simulation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Suhee,Kim, Hyunwoo,Lee, Soo-Hyeon,Cho, Ilhan,Kang, Seongwoo,Bae, Junwoo,Kim, Woosun,Ahn, Soomin,Choi, Jihye,Kim, Sang-Ki,Do, Yoonjung,Yoo, Jae Gyu,Park, Jinho,Yu, DoHyeon 한국조명·전기설비학회 2017 한국조명·전기설비학회 학술대회논문집 Vol. No.
<P>Acute lymphocytic leukemia (ALL) is uncommon lymphoid malignancy in dogs, and its diagnosis is challenging. A 14-year-old spayed female mixed breed dog was transferred to a veterinary medical teaching hospital for an immediate blood transfusion. The dog showed lethargy, pale mucous membranes, and a weak femoral pulse. Complete blood count revealed non-regenerative anemia and severe leukopenia with thrombocytopenia. ALL was tentatively diagnosed based on the predominance of immature lymphoblasts on blood film examination. For confirmation of lymphoid malignancy, PCR for antigen receptor rearrangement (PARR) on a peripheral blood sample and flow cytometry analysis were performed after blood transfusion. Flow cytometry analysis revealed that lymphocyte subsets were of normal composition, but PARR detected a T-cell malignancy. The dog was diagnosed with ALL and survived 1 wk after diagnosis. In conclusion, after blood transfusion, flow cytometry was not a reliable diagnostic method for an ALL dog, whereas PARR could detect lymphoid malignancy. Our results suggest that PARR should be the first-line diagnostic tool to detect canine lymphoid malignancy after a blood transfusion.</P>
Hyunwoo Kim(김현우),Myeong-jun Kim(김명준),Jaeik Jang(장재익),Jungha Kim(김정하) 한국자동차공학회 2021 한국자동차공학회 부문종합 학술대회 Vol.2021 No.6
Recently a lot of brand-new techniques of ADAS are being shown. Not only Longitudinal control but also lateral control system of the vehicle is getting commercialized by lots of motor company. This paper introduces a way of perception system of the autonomous vehicle which enables to change the lane. This system requires 3D LiDAR sensor and HD map (High-Definition map) for localization of the vehicle. It detects the objects on the road with 3D LiDAR sensor by making ROI (Region of interest) with curvilinear variable parameter acquired from the HD map. In addition, cluster the pointcloud and pick the vehicle using filters. Finally, this system acquires several key-data such as type and distance of the near-located-vehicle for the ego-vehicle to have enough data for lane change.
Kim, Young Jin,Kim, Si Hyun,Ahn, Junggu,Cho, Soongmoon,Kim, Dongchun,Kim, Kwanghyun,Lee, Heegun,Son, Hyunwoo,Lee, Hee Joo,Yong, Dongeun,Choi, Jun Yong,Kim, Hye Ran,Shin, Jeong Hwan Elsevier 2017 Anaerobe Vol.48 No.-
<P>Conclusion: Clostridium perfringens toxin is relatively common, and we should consider the possibility of its presence in patients suspected of having AAD, especially if C difficile tests are negative. (C) 2017 Elsevier Ltd. All rights reserved.</P>
Kim, Hyunwoo,Lee, Duhwan,Kim, Jinhwan,Kim, Tae-il,Kim, Won Jong American Chemical Society 2013 ACS NANO Vol.7 No.8
<P>Graphene oxide has unique physiochemical properties, showing great potential in biomedical applications. In the present work, functionalized reduced graphene oxide (PEG-BPEI-rGO) has been developed as a nanotemplate for photothermally triggered cytosolic drug delivery by inducing endosomal disruption and subsequent drug release. PEG-BPEI-rGO has the ability to load a greater amount of doxorubicin (DOX) than unreduced PEG-BPEI-GO <I>via</I> π–π and hydrophobic interactions, showing high water stability. Loaded DOX could be efficiently released by glutathione (GSH) and the photothermal effect of irradiated near IR (NIR) in test tubes as well as in cells. Importantly, PEG-BPEI-rGO/DOX complex was found to escape from endosomes after cellular uptake by photothermally induced endosomal disruption and the proton sponge effect, followed by GSH-induced DOX release into the cytosol. Finally, it was concluded that a greater cancer cell death efficacy was observed in PEG-BPEI-rGO/DOX complex-treated cells with NIR irradiation than those with no irradiation. This study demonstrated the development of the potential of a PEG-BPEI-rGO nanocarrier by photothermally triggered cytosolic drug delivery <I>via</I> endosomal disruption.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-8/nn403096s/production/images/medium/nn-2013-03096s_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn403096s'>ACS Electronic Supporting Info</A></P>
Kim, Hyunwoo,Kim, Sangsub,Kim, Hyunki,Lee, Jaeseob,Kim, Sangsoo,Choi, Byoungdeog American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.10
<P>We investigated the electrical properties of solution-processed nanolaminates composed of zirconium oxide (ZrO2) and aluminum oxide (Al2O3) as gate insulator materials for thin-film transistors (TFTs). We fabricated MOS capacitors using Al2O3/ZrO2/Al2O3 and ZrO2/Al2O3/ZrO2 nanolaminate stacks through solution processing. The fabricated nanolaminates showed low leakage current densities and high dielectric constants. Also, solution-processed InSnZnO (ITZO) TFTs were fabricated on nanolaminates. Among these devices, the Al2O3/ZrO2/Al2O3 stack showed the best performance in terms of its switching operation, with a high on/off current ratio (>10(6)), high mu(sat) (0.28 cm(2)/Vs), and low subthreshold swing (0.25 V/dec). The superior characteristics of these nanolaminates originated from the high dielectric constant of ZrO2 (>20) and the high band gap energy of Al2O3 (8.9 eV), which generates a large band offset between the gate insulator and active layer to effectively block the leakage current.</P>