http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
( Chae Jin Lim ),( Yong-moon Lee ),( Seung Goo Kang ),( Hyung W. Lim ),( Kyong-oh Shin ),( Se Kyoo Jeong ),( Yang Hoon Huh ),( Suin Choi ),( Myungho Kor ),( Ho Seong Seo ),( Byeong Deog Park ),( Keedo 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by SA-β-gal staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
Lim, Sun M.,An, Hee-Jung,Park, Hyung S.,Kwon, Hyeong J.,Y. Kim, Eun,Hur, Jin,Moon, Yong W. Williams & Wilkins Co 2018 Medicine Vol.97 No.31
<P><B>Abstract</B></P><P><B>Rationale:</B></P><P>Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (<I>EML4-ALK</I>), a distinct molecular entity, is highly sensitive to ALK tyrosine kinase inhibitors (TKIs) such as crizotinib or ceritinib. Interstitial lung disease is a rare (1.2%) pulmonary toxicity that can result from ALK TKIs, however, organizing pneumonia has not been reported to date.</P><P><B>Patient concerns:</B></P><P>A 45-year-old Korean female with <I>ALK</I>-rearranged metastatic lung adenocarcinoma underwent ceritinib treatment and exhibited a partial response, until she developed organizing pneumonia resembling disease progression.</P><P><B>Diagnoses:</B></P><P>Multiple rebiopsies confirmed the involvement of organizing pneumonia in the pathology.</P><P><B>Interventions:</B></P><P>Ceritinib was stopped and the patient was treated with intravenous antibiotics followed by oral antibiotics for two weeks.</P><P><B>Outcomes:</B></P><P>After recovering from organizing pneumonia, ceritinib was successfully rechallenged and the patient attained a complete response.</P><P><B>Lessons:</B></P><P>When a new mass-like lesion develops in the lungs of responding patients, benign lung conditions, including organizing pneumonia should be considered in differential diagnoses.</P>
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
Lim, Chae Jin,Lee, Yong-Moon,Kang, Seung Goo,Lim, Hyung W.,Shin, Kyong-Oh,Jeong, Se Kyoo,Huh, Yang Hoon,Choi, Suin,Kor, Myungho,Seo, Ho Seong,Park, Byeong Deog,Park, Keedon,Ahn, Jeong Keun,Uchida, Yos The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by $SA-{\beta}-gal$ staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
Jeong, Wooyoung,Lim, Whasun,Kim, Jinyoung,Ahn, Suzie E,Lee, Hyung Chul,Jeong, Jae-Wook,Han, Jae Yong,Song, Gwonhwa,Bazer, Fuller W Society for the Study of Reproduction [etc.] 2012 BIOLOGY OF REPRODUCTION Vol.86 No.6
<P>Egg formation and embryonic development occur as the yolk passes through the magnum, isthmus, and shell gland of the oviduct before oviposition in hens. The present study identified candidate genes associated with secretory function of the chicken oviduct after ovulation and contributing to egg formation and oviposition. Hens (n = 5 per time point) were euthanized to recover the reproductive tract when the egg was in the magnum (3 h after ovulation) and the shell gland (20 h after ovulation). Total RNA was extracted from each segment of the oviducts and subjected to Affymetrix chicken GeneChip analysis. Quantitative PCR and in situ hybridization analyses of selected genes confirmed the validity of the gene expression patterns detected using microarray analysis. In particular, ACP1, CALB1, CYP26A1, PENK, RCAN1 and SPP1 expression increased significantly in the shell gland between 3 h and 20 h postovulation, whereas only RCNA1 expression increased significantly in the magnum between 3 h and 20 h postovulation. Results of the high-throughput analysis revealed cell-specific and temporal changes in gene expression in the oviduct at 3 h and 20 h postovulation in laying hens provide novel insight into changes at the molecular and cellular levels of candidate genes related to formation of the egg and oviposition.</P>
Aquatide Activation of SIRT1 Reduces Cellular Senescence through a SIRT1-FOXO1-Autophagy Axis
임채진,이용문,강승구,Hyung W. Lim,신경오,정세규,허양훈,최수인,고명호,서호성,박병덕,박기돈,안정근,Yoshikazu Uchida,박경호 한국응용약물학회 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5
Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by SA-β-gal staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.
Lee, Seonhwa,Kim, Hyung Ju,Lim, Eun Ja,Kim, Youngmin,Noh, Yuseong,Huber, George W.,Kim, Won Bae The Royal Society of Chemistry 2016 GREEN CHEMISTRY Vol.18 No.9
<P>We demonstrate an electrocatalytic reactor system for the partial oxidation of glycerol in an acidic solution to produce value-added chemicals, such as dihydroxyacetone (DHA), glyceraldehyde (GAD), glyceric acid (GLA), and glycolic acid (GCA). Under optimized conditions, the carbon-supported bimetallic PtSb (PtSb/C) catalyst was identified as a highly active catalyst for the selective oxidation of glycerol in the electrocatalytic reactor. The product selectivity can be strongly controlled as a function of the applied electrode potential and the catalyst surface composition. The main product from the electrocatalytic oxidation of glycerol was DHA, with a yield of 61.4% of DHA at a glycerol conversion of 90.3%, which can be achieved even without using any oxidants over the PtSb/C catalyst at 0.797 V (vs. SHE, standard hydrogen electrode). The electrocatalytic oxidation of biomass-derived glycerol represents a promising method of chemical transformation to produce value-added molecules.</P>