21세기 한국사회 : 지식사회냐 정보사회냐

임현진,서이종 한국사회문화학회 2000 사회와 문화 Vol.12 No.-

This paper deals with the characteristics in the introduction of the concept of "knowledge society" and "information society" for Korean society at the 21st Century and with a usability of "knowledge-information society" as a conceptual synthesis. Chapter 2 shows that the concept of information society war introduced critically in the late 1980s and developed into an empirical research theme in the beginning of 1990s, with various conceptual variances, that the concept of knowledge society war introduced in the science of economy and business in the 1990s with various conceptual variances. Chapter 3/4 shows that information society concentrate on the information basis of knowlege transmission and storage, while knowledge society concentrate on the creation of knowledge as contents, that two concepts can be conceptually incorporated into "knowledge-based information society" or "information-based knowledge society", and finally into "knowledge-information society".

A case of hand-foot syndrome after chemotherapy of Hodgkin lymphoma

( Hyun Yi Suh ),( Joo Yoon Bae ),( Hong Lim Kim ),( Kyung Ho Kim ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Hand-foot syndrome (HFS), also known as palmoplantar erythrodysesthesia or acral erythema, is a well-documented adverse effect of numerous chemotherapeutic agents. The most common agents are pegylated liposomal doxorubicin (PLD), capecitabine and 5-fluorouracil (FU), cytarabine, and docetaxel. Newer targeted multikinase inhibitors (MKIs) also cause adverse effects involving the hands and feet. We report a case of Hand-foot syndrome after chemotherapy in a Hodgkin lymphoma patient. A 50-year-old male visited our clinic for well-demarcated painful erythematous indurating patches on his hands and feet. The skin lesions on the foot and hands developed the 4 days ago and the erythema and edema aggravated. He had been diagnosed with Hodgkin lymphoma about 2weeks ago and he was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine about 9 days ago. Punch biopsy was performed and histologically showed hyperkeratosis, parakeratosis, spongiosis in epidermis and keratinocytes with basal cell hydropic changes and apoptosis. Papillary dermal edema and perivascular lymphocytic infiltrates were seen in the dermal layers. Therefore, we could make a diagnosis as Hand-foot syndrome. We treated with systemic steroid and antihistamine with topical steroid for his skin lesions and symptoms. We consider that hand-foot syndrome was induced by doxorubicin, the chemotherapeutic agent of Hodgkin lymphoma treatment and report this impressive case.

[P299] Hand-foot-mouth Disease in an Immunocompetent Adult

( Hyun Yi Suh ),( Jae In Lee ),( Joo Yoon Bae ),( Hong Lim Kim ),( Hye Jung Jung ),( Mi Youn Park ),( Jai Il Youn ),( Ji Young Ahn ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Hand-foot-mouth (HFM) disease is a highly infectious disease characterized by multiple vesicles on the hands, feet and in the oral cavity. It is primarily a disease of children and coxsackie virus A16 is the most common virus. Clinically, the onset is characterized by vesicles with fever and symptoms usually subside within 7 to 10 days. Although several cases of adult HFM disease have been reported, it has been rarely reported in healthy adults. We report a case of hand-foot-mouth disease in an immunocompetent adult. A 78-year-old female visited our clinic for multiple erythematous vesicular papules on the hands, feet and oral ulcer. The skin lesions developed the 3 days ago and were aggravated. Histopathological findings showed hyperkeratosis, parakeratosis, spongiosis, keratinocyte apoptosis in epidermis. Papillary dermal edema, perivascular lymphocytic infiltrates and dilated vessels were seen in the dermal layers. We did symptomatic treatments. Dermatologists should be aware that HFM disease can occur in adults with intact immune systems. We report this impressive case of hand-foot-mouth disease in an immunocompetent adult.

Psoriasis developed after tattooing

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Koebner phenomenon was initially reported as the formation of psoriasiform lesions after cutaneous trauma in the uninvolved skin of people with psoriasis in 1877 by Heinrich Koebner. More recently, the definition has been extended to include lesions developed after trauma in people with no pre-existing dermatosis. A 26-year-old man visted our clinic for erythematous scaly papuloplaques on the left arm around tattoo and forehead. He had tattoos on his arm before 5 months. The skin lesions on the forehead had appeared first since the 4 month and then on his forearms around tattoos, they had been appeared since 1month. The lesions were mild itchy. He had no family history of skin problems and no previous skin conditions. A skin biopsy was performed in the left forearms. Skin biopsy in lesion showed parakeratosis. perivascular inflammatory and the exogenous pigment of the tattoo is in the dermis. We treated with topical steroid agent for his skin lesion. We report this impressive case that getting a tattoo in the patient without pre-existing dermatosis should induce psoriasis by Koebner phenomenon.

A case of HIV associated pruritic papular eruption

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Papular pruritic eruption (PPE) of HIV has been considered to be within the spectrum of pruritic papular disorders in HIV. The primary skin lesions for PPE are firm, well-demarcated, erythematous papules originating on the extremities and occasionally spreading on the trunk. Because of severe pruritus, skin lesions are excoriated papules, marked postinflammatory pigment changes and eventually prurigo-like nodules. Histologically, they show superficial and deepinflammation and perivascular and interstitial infiltration of lymphocytes and eosinophils. 48-year-old male who visited our clinic for intensively pruritic scattered erythematous papules with crust and excoriations on the trunk and upper extremities. It appeared in 2 years ago. We implemented punch biopsy in the skin lesions and it histologically showed perifollicular and perivascular lymphocytic and eosinophilic infiltration. Therefore, we could make a diagnosis as HIV-PPE. We treated with antihistamine for his skin lesion and symptom. Recently, Patients infected with HIV have been increasing so we report this impressive case of HIV associated dermatosis.

New-onset Psoriasis Induced by Adalimumab Administered for Rheumatoid Arthritis

( Hyun-yi Suh ),( Kyung-ho Kim ),( Ji-young Ahn ),( Mi-youn Park ),( Jai-il Youn ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.7

Tumor necrosis factor alpha (TNF-α) is a cytokine central to the pathological responses involved in rheumatoid arthritis (RA), psoriasis, and psoriatic arthritis1. Adalimumab, a recombinant human IgG monoclonal antibody, selectively blocks TNF-α and is considered an alternative therapeutic agent for treatment of RA. However, new-onset psoriasis or the worsening of pre-existing psoriasis is reportedly an adverse effect associated with its use and is defined as a “paradoxical reaction”. A 54-year-old woman with known history of RA refractory to conventional therapies was treated with adalimumab (40 mg every 2 weeks). She related no history of skin rashes or psoriasis. Throughout the 4 months (until the 8th injection) following treatment initiation, she reported no skin problems, and her arthritis was well controlled. After the 9th injection of adalimumab, she developed erythematous patches with scales on her back. Physical examination showed scattered erythematous patches and plaques on her lower back and legs. Erythematous papules with pustules appeared on the hypothenar area of her left palm (Fig. 1A∼C). A punch biopsy performed on the left leg revealed histopathological findings characteristic of psoriasis. The lesions resolved with use of topical calcipotriol (Daivonex^ⓡ cream). The biologics that were being administered were changed, and treatment with tocilizumab (interleukin-6 receptor antagonist) was continued for her arthritis, and there were no psoriatic skin lesions noted. High levels of TNF-α have been found in the synovial fluid of patients diagnosed with RA and psoriatic skin lesions¹. The concomitant presence of RA and skin psoriasis in the same patient is rare. The German National Data Bank for Rheumatological Diseases has reported that only 0.2% of patients with RA and 0.3% of patients with seropositive rheumatoid arthritis simultaneously exhibited psoriasis². The British Society for Rheumatology Biologics Register has reported an incidence of 1.04 per 1000 person-years for the development of psoriasis following treatment with TNF-α inhibitors³. Many of these cases of psoriasis occurred within 9 months of initiating anti-TNFα therapy (median 6 months). Adalimumab, in particular, has been noted to cause new-onset pustular and palmoplantar psoriasis unlike in our case³. The role of TNF-α inhibitors in the etiology of new-onset psoriasis remains unclear. RA patients receiving systemic TNF-α inhibitors exhibit an increased number of Th1 lymphocytes in their peripheral circulation, a possible secondary effect of decreased exchange between previous regions of inflammation (i.e., the joints)⁴. However, overexpression of interferon alpha (IFN-α) in the tissue could induce T-cell migration to the psoriatic dermis and subsequent cell homing to the epidermis1. Another potential explanation could be related to the heterogeneity of psoriasis. Polymorphisms in the TNF receptor II gene have not only been associated with a lower clinical response to anti-TNF therapy5, but may also play a role in the paradoxical response to TNF-α inhibitors. In the current case, clinical manifestations included a plaque on the trunk and pustular lesions on the palm. TNF-α is a recognized contributor to the development of plaque psoriasis. However, lower expression of this cytokine has been demonstrated in the palmar eccrine sweat glands and in the skin of patients with palmoplantar pustulosis⁵. This implies the wide variation in clinical symptoms based on levels of TNF-α measured following administration of TNF-α inhibitors. We describe the case of a Korean patient treated with TNF-α inhibitors for the management of rheumatic disease who subsequently developed new-onset psoriasis. We propose that further studies would be needed to investigate risk factors involved in the induction of such paradoxical psoriasis.

Association of Hepatitis B Virus Infection and Psoriasis

( Hyun-yi Suh ),( Yong-bum Yoon ),( Ji-young Ahn ),( Mi-youn Park ),( Jai-il Youn ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.6

Paradoxical psoriasis induced by biologic therapies

( Hyun Yi Suh ),( Hong Lim Kim ),( Kyung Ho Kim ),( Jae Wook Jeon ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Biologic therapies currently approved for the treatment of moderate-to-severe plaque psoriasis work well. Administrations of those are beneficial in a variety of chronic inflammatory conditions. Recent reports have illustrated the paradoxical development of psoriasis after biologic therapies. A 30-year-old man presented widespread scaly erythematous patches on the whole body involvement after treatment with the third dose of infliximab. He was diagnosed with palmoplantar psoriasis 6 years ago. The patients had been treated either neotigason or cyclosporine with eximer phototherapy for 2 years 6 months before visiting our psoriasis clinic. He was started on the injections of infliximab, but there was no improvement after the first dose. After receiving third dose of infliximab, the patient had experienced worsening of his plaque psoriasis on the whole. We changed other biologics, ustekinumab, anti-IL-12/23 p40 monoclonal antibody. He was treated with ustekinumab. Although receiving the second dose of ustekinumab, the skin lesions were not improved and worsening of appearing pustules on the palm and sole. We treated with cyclosporin and with calcipotriol agent (Daivonex® cream) for his skin lesion. Herein, we report this impressive case of induced paradoxical psoriasis after treating on TNF-a inhibitor and IL-12/23 inhibitor.

A Case of Subungual Verruca in All Fingers

( Hyun-yi Suh ),( Hong-lim Kim ),( Kyung-ho Kim ),( Mi-youn Park ),( Jai-il Youn ),( Ji-young Ahn ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.1

Viral warts are common, benign, and frequently irritating skin lesions caused by the human papillomavirus (HPV). Direct skin trauma is the usual cause of local viral infection ¹. However, development of infection depends on various local and systemic factors such as working environment or immunocompromise². Subungual verruca is HPV infection of the nail bed. We report a rare case with subungual verruca in all 10 fingers. A 64-year-old man visited our clinic with subungual hyperkeratotic plaques in all fingers (Fig. 1A, B). The condition initially appeared in the hyponychium of the right first finger 3 years prior, and had since spread to all fingers. There was no evidence of trauma or underlying disease. The patient`s occupation was that of a professional scrubber, who scrubs down bathrooms in a public bathhouse. Potassium hydroxide (KOH) test was performed on all fingers to assess the possibility of a fungal infection(s); however, the results were negative. Subsequent biopsy and histological analysis of the lesion indicated papillomatous hyperplasia with hypergranulosis and parakeratosis in the epidermis. Viral inclusions were found in the upper epidermis. The biopsy tissue was subjected to liquid bead microarray assay for HPV detection and genotyping. The HPV oligonucleotide microarray detected type 11 and type 58 HPV. Thus, the final diagnosis was subungual warts. The patient was provided only three sessions of cryotherapy treatment and the lesions showed improvement after each session. However, owing to the pain during treatment, the patient did not return after the third session. Warts can develop from a few weeks to greater than a year after infection with HPV<sup>1</sup>. A less common area of infection is under the nail plate. Subungual warts may appear as a linear growth that penetrates deep underneath the nail plate, producing a longitudinal band of onycholysis, or a nodular lesion that lifts the nail plate ultimately leading to onycholysis 2. Lesion characteristics are influenced by the virus type as well as environmental and host factors<sup>4</sup>. Butcher`s warts are related to HPV type 7³. People in certain occupations have an increased risk of ungual warts. Up to 23% of handlers of meat and fish develop warts due to continuous skin maceration⁵. HPV is highly resistant to heat, desiccation, and detergents. Our patient worked in a communal washing area and his hands were subject to continuous skin maceration. In addition, one study⁵ suggested that public shower users are at greater risk for plantar warts than those who do not use such communal showers. Therefore, our patient`s occupation and constant exposure to environ-mental factors contributed to the development of his skin lesions. Treatment for warts should be prescribed based on factors such as lesion size, number, and immunity². Further-more, subungual warts may be difficult to treat due to their location. The most common forms of wart treatment are topical salicyclic acid application, cryotherapy with nitrogen, and laser therapy. In conclusion, we report a rare case in which an otherwise healthy man developed subungual warts on all fingers; the most probable cause was the environmental factor related to his occupation.

P114 Efficacy of bipolar radiofrequency (Polaris™) and 1,550-nm fractional erbium-glass laser (Mosaic™) for photoaging

( Hyun Yi Suh ),( Joo Yoon Bae ),( Hong Lim Kim ),( Kyung Ho Kim ),( Ji Young Ahn ),( Mi Youn Park ),( Jai Il Youn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Multiple therapies involving ablative and nonablative techniques have been developed for rejuvenation of photodamaged skin. Radiofrequency (RF) is emerging as a gentler, nonablative skin-tightening device that delivers uniform heat to the dermis at a controlled depth. Objectives: To compare the efficacy of bipolar radiofrequency (Polaris™) and 1,550-nm fractional erbium-glass laser (Mosaic™) for the treatment of photoaging through a randomized, split-face, patient- and evaluator-blind study. Methods: We evaluated the clinical effects after the treatment of photoaging. Ten Asian women (Fitzpatrick skin type III to IV) were treated 9 weeks of treatment (3 sessions at 3-week intervals) with bipolar radiofrequency on one side of the face and combination therapy with non-ablative bipolar radiofrequency and 1,550-nm fractional erbium-glass laser on the other side. Results: Among 10 cases of patients, 4 cases were male and 6 cases were female. Based on patient’s questionnaires, patients felt more effective (85%) when treated with both lasers compared to one laser were treated (62%). On the face of combination therapy, the effective rate at weeks 6, 9, and 12 was 43%, 65%, and 72%, respectively; in the other group, 32%, 42%, and 53%. As the results of PCR, elastin and collagen were increased after laser treatments. Conclusion: This study suggests that bipolar radiofrequency combined with 1,550-nm fractional erbium-glass laser could be effective treatment for photoaging.