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( Dongyup Hahn ),( Hiyoung Kim ),( Inho Yang ),( Jungwook Chin ),( Hoosang Hwang ),( Dong Hwan Won ),( Byoungchan Lee ),( Sang Jip Nam ),( Merrick Ekins ),( Hyukjae Choi ),( Heonjoong Kang ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Three new structurally related depsipeptides, halieylindramides F-H (1-3), and two known halieylindra-mides were isolated from a Petrosia sp. marine sponge collected off the shore of Youngdeok-Gun, East Sea, Republic of Korea. Their planar structures were elucidated by extensive spectroscopic data analyses including ID and 2D NMR data as well as MS data. The absolute configurations of halicylin-drarnides F-H (1-3) were determined by Marfey``s method in combination with Edman degradation. The absolute config-urations at C-4 of the dioxyindolyl alanine (Dioia) residues of halieylindramides G (2) and H (3) were determined as 4S and 4R, respectively, based on ECD spectroscopy. The C-2 configurations of Dioia in 2 and 3 were speculated to both be 2R based on the shared biogenesis of the halicylindramides. Halieylindrarnides F (1), A (4), and C (5) showed human farnesoid X receptor (hFXR) antagonistic activities, but did not bind directly to hFXR.