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Prognostic value of pre-treatment human papilloma virus DNA status in cervical cancer
Chong, Gun Oh,Lee, Yoon Hee,Han, Hyung Soo,Lee, Hyun Jung,Park, Ji Young,Hong, Dae Gy,Lee, Yoon Soon,Cho, Young Lae Elsevier 2018 Gynecologic oncology Vol.148 No.1
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Although the relationship between human papilloma virus (HPV) and cervical cancer is well established, the prognostic value of HPV status has not been determined, largely because previous studies have yielded conflicting results. This study aimed to investigate the prognostic value of pre-treatment HPV DNA for predicting tumor recurrence in cervical cancer.</P> <P><B>Methods</B></P> <P>The study included 248 eligible patients who provided cervical cell specimens for HPV genotyping before surgery or concurrent chemoradiotherapy (CCRT). Of these 248 patients, 108 were treated with radical hysterectomy for International Federation of Gynecology and Obstetrics (FIGO) stage IB1–IIA cervical cancer, and 140 were treated with CCRT for FIGO stage IB2–IV cervical cancer.</P> <P><B>Results</B></P> <P>HPV 16 and 18 were the two most common HPV types detected, with prevalence rates of 52.4% and 12.5%, respectively. The pre-treatment HPV DNA test showed that 18.5% of cervical cancers were HPV negative. Multivariate analysis showed that HPV negativity was associated with poorer disease-free survival (DFS) than HPV-positive status (hazard ratio [HR], 3.97; 95% confidence interval [CI], 1.84–8.58; <I>p</I> =0.0005), and patients with HPV 16-positive cancers had better DFS (HR, 0.41; 95% CI, 0.23–0.72; <I>p</I> =0.0019). In the surgery group, only HPV 16 positivity was significantly correlated with DFS (HR, 0.34; 95% CI, 0.12–0.96; <I>p</I> =0.0416). In the CCRT group, only HPV negativity was significantly correlated with DFS (HR, 3.75; 95% CI, 1.78–7.90; <I>p</I> =0.0005).</P> <P><B>Conclusions</B></P> <P>Pre-treatment HPV DNA status may be a useful prognostic biomarker in cervical cancer. The presence of HPV 16 DNA was associated with better DFS, and HPV negativity was associated with worse DFS. However, larger sample sizes and more comprehensive studies are required to verify our findings.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pretreatment HPV DNA status may be a useful prognostic biomarker for predicting disease recurrence in cervical cancer. </LI> <LI> HPV 16 infection was associated with better survival, particularly in the surgery group. </LI> <LI> HPV negativity was associated with worse survival, particularly in the CCRT group. </LI> </UL> </P>
New Multi-Output LLC Resonant Converter for High Efficiency and Low Cost PDP Power Module
Chong-Eun Kim,Gun-Woo Moon,Jun-Young Lee,Kwan-Il Oh,Joong-Yeol Kwon 전력전자학회 2006 전력전자학술대회 논문집 Vol.- No.-
A new multi-output LLC resonant converter is proposed for high efficiency and low cost plasma display panel (PDP) power module. In the proposed converter, zero-voltage (ZV) tum-on of the primary MOSFETs and zero-voltage (ZC) turn-on and turn-off of the secondary diodes are guaranteed in the overall input voltage and output load ranges. In addition, the primary MOSFETs and the secondary diodes have the low voltage stresses clamped to input and the output voltages, respectively. Therefore, the proposed converter shows the high efficiency due to the minimized switching and conduction losses. Moreover, by employing the transformer with multiple secondary windings, the proposed converter can have multiple outputs, which show the great cross-regulation characteristics. Therefore, the proposed converter is suitable for high efficiency and low cost PDP power module.