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RISS 인기검색어
- 검색키워드
- 저자 : ( Florin Crisan ) (검색결과 5 건)
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Inhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility
( Yi Yang ),( Thanh Thi Nguyen ),( Min Hye Jeong ),( Florin Crisan ),( Young Hyun Yu ),( Hyung Ho Ha ),( Kyung Hee Choi ),( Hye Gwang Jeong ),( Tae Cheon Jeong ),( Kwang Youl Lee ),( Kyung Keun Kim ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Lichens are symbiotic organisms that produce various unique chemicals that can be used for pharmaceutical purposes. With the aim of screening new anti-cancer agents that inhibit cancer cell motility, we tested the inhibitory activity of seven lichen species collected from the Romanian Carpathian Mountains against migration and invasion of human lung cancer cells and further investigated the molecular mechanisms underlying their anti-metastatic activity. Among them, Alectoria samentosa, Flavocetraria nivalis, A/ectoria ochro/euca, and Usnea florida showed significant inhibitory activity against motility of human lung cancer cells. HPLC results showed that usnic acid is the main compound in these lichens, and (+)-usnic acid showed similar inhibitory activity that crude extract have. Mechanistically,~-catenin-mediated TOPFLASH activity and KITENIN-mediated AP-1 activity were decreased by (+ )-usnic acid treatment in a dose-dependent manner. The quantitative real-time PCR data showed that (+)-usnic acid decreased the mRNA level of C044, Cyclin 01 and c-myc, which are the downstream target genes of both ~-catenin/LEF and c-jun/AP-1. Also, Rac1 and RhoA activities were decreased by treatment with (+)-usnic acid. Interest-ingly, higher inhibitory activity for cell invasion was observed when cells were treated with (+)-usnic acid and cetuximab. These results implied that (+)-usnic acid might have potential activity in inhibition of cancer cell metastasis, and (+)-usnic acid could be used for anti-can-cer therapy with a distinct mechanisms of action.
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Inhibitory Activity of (+)-Usnic Acid against Non-Small Cell Lung Cancer Cell Motility
( Yi Yang ),( Thanh Thi Nguyen ),( Min-hye Jeong ),( Florin Crisan ),( Young Hyun Yu ),( Hyung-ho Ha ),( Kyung Hee Choi ),( Hye Gwang Jeong ),( Tae Cheon Jeong ),( Kwang Youl Lee ),( Kyung Keun Kim ) 전남대학교 약품개발연구소 2016 약품개발연구지 Vol.25 No.-
Lichens are symbiotic organisms that produce various unique chemicals that can be used for pharmaceutical purposes. With the aim of screening new anti-cancer agents that inhibit Cancer cell motility, we tested the inhibitory activity of seven lichen species collected from the Romanian Carpathian Mountains against migration and invasion of human lung cancer cells and further investigated the molecular mechanisms underlying their anti-metastatic activity. Among them, Alectoria samentosa, Flavocetraria nivalis, Alectoria ochroleuca, and Usnea florida showed significant inhibitory activity against motility of human lung cancer Cells. HPLC results showed that usnic acid is the main compound in these lichens, and (+)-usnic acid showed similar inhibitory activity that crude extract have. Mechanistically, β-catenin-mediated TOPFLASH activity and KlTENlN-mediated AP-1 activity were decreased by (+)-usnic acid treatment in a dose-dependent manner. The quantitative real-time PCR data showed that(+)-usnic acid decreased the mRNA level of CD44, Cyclin D1 and c-myc, which are the downstream target genes of both β-catenin/LEF and c-jun/AP-1. Also, Rac1 and RhoA activities were decreased by treatment with(+)-usnic acid. Interest-ingly, higher inhibitory activity for cell invasion was observed when cells were treated with (+)-usnic acid and cetuximab. These results implied that(+)-usnic acid might have potential activity in inhibiyion of cancer cell metastasis, and(+)-usnic acid could be used for anti-can-cer therapy with a distinct mechanisms of action.
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Lichen Mycota in South Korea: The Genus Usnea
( Udeni Jayalal ),( Santosh Joshi ),( Soon Ok Oh ),( Young Jin Koh ),( Florin Crisan ),( Jae Seoun Hur ) 한국균학회 2013 Mycobiology Vol.41 No.3
Usnea Adans. is a somewhat rare lichen in South Korea, and. in nearly two decades, no detailed taxonomic or revisionary study has been conducted. This study was based on the specimens deposited in the lichen herbarium at the Korean Lichen Research Institute, and the samples were identified using information obtained from recent literature. In this study, a total or eight species of Usnea, including one new record, Usnea hakonensis Asahina, are documented. Derailed descriptions of each species with their morphological, anatomical, and chemical characteristics are provided. A key to all known Usnea species in South Korea is also presented.
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The Lichen Genus Sticta in South Korea
( Udeni Jayalal ),( Santosh Joshi ),( Soon Ok Oh ),( Jung A Kim ),( Young Jin Koh ),( Florin Crisan ),( Jae Seoun Hur ) 한국균학회 2014 Mycobiology Vol.42 No.1
Sticta (Schreber.) Ach. is one of the common lichen genera in tropical and subtropical regions, but not in the Korean Peninsula. For almost two decades, no detailed taxonomic or revisionary study has been done on this genus. This study was based on the specimens deposited in the lichen herbarium at the Korean Lichen Research Institute, and the samples were identified on the basis of recent literature. In this revisionary study, a total of eight species of Sticta, including a newly recordedone are documented. These species include Sticta fuliginosa (Dicks.) Ach., Sticta gracilis (Mull. Arg.) Zahlbr., Sticta limbata (Sm.)Ach., Sticta nylanderiana Zahlbr., Sticta sublimbata (J. Steiner) Swinscow & Krog, Sticta weigelii (Ach.) Vain., Sticta wrightii Tuck.,and Sticta yatabeana Mull. Arg. Detailed descriptions of S. nylanderiana, S. sublimbata, S. weigelii, and S. yatabeana with theirmorphological, anatomical, and chemical characteristics are provided. A key description of all known Sticta species of the Korean Peninsula is also presented.
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( Thanh Thi Nguyen ),( Somy Yoon ),( Yi Yang ),( Ho Bin Lee ),( Soo Nok Oh ),( Min Hye Jeong ),( Jong Jin Kim ),( Sung Tae Yee ),( Florin Crisan ),( Cheol Moon ),( Kwang Youl Lee ),( Kyung Keun Kim ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-
Lichens are symbiotic organisms which produce distinct secondary metabolic products. In the present study, we tested the cytotoxic activity of 17 lichen species against several human cancer cells and further investigated the molecular mechanisms underlying their anti-cancer activity. We found that among 17 lichens species, F. cucullata exhibited the most potent cytotoxicity in several human cancer cells. High performance liquid chromatography analysis revealed that the acetone extract of F. cucullata contains usnic acid, salazinic acid, Squamatic acid, Baeomycesic acid, d-protolichesterinic acid, and lichesterinic acid as subcomponents. MlT assay showed that cancer cell lines were more vulnerable to the cytotoxic effects of the extract than non-cancer cell lines. Furthermore, among the identified subcomponents, usnic acid treatment had a similar cytotoxic effect on cancer cell lines but with lower potency than the extract. At a lethal dose, treatment with the extract or with usnic acid greatly increased the apoptotic cell population and specifically activated the apoptotic signaling pathway; however, using sub-lethal doses, extract and usnic acid treatment decreased cancer cell motility and inhibited in vitro and in vivo tumorigenic potentials. In these cells, we observed significantly reduced levels of epithelialmesenchymal transition (EMn markers and phosphor-Akt, while phosphor-c-Jun and phosphor-ERK1/2 levels were only marginally affected. Overall, the anti-cancer activity of the extract is more potent than that of usnic acid alone. Taken together, F. cucullata and its subcomponent, usnic acid together with additional component, exert anti-cancer effects on human cancer cells through the induction of apoptosis and the inhibition of EMT.
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