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( G Teuber ),( S Mauss ),( D Huppe ),( E Zehnter ),( M P Manns ),( T Dahhan6 ),( U Meyer ),( T Witthoft ),( B Moller9,),( N Dikopoulos ),( J Brack ),( B Stade ),( M Bilzer ),( The Bng Hepatitis Study 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background and Aims: Recently, it has been shown for the overall G1 population that anemia as well as the maximal hemoglobin (Hb) decline during peginterferon/RBV treatment is associated with higher SVR rates. We here investigated whether the maximal Hb decline influences SVR rates in difficult-to-treat patients undergoing Peg2b/RBV therapy for HCV G1 infection in real-life. Methods: Data of patients treated for G1 infection within the German Peg2b/RBV observational study were retrospectively analyzed. In this real-life cohort study G1 infection was treated with Peg2b 1.5 μg/kg/wk + weight-based RBV (800-1200 mg/day) for up to 48 wks at 285 sites. Subjects who discontinued for non-response or for any other reasons were included in the analysis. SVR was defined as undetectable serum HCV-RNA 24 wks after EOT response. Only one patient received erythropoietin treatment for anemia. Results: 1851 patients had baseline and at least one Hb measurement during therapy. Overall SVR rate was 42.6% (789/1851). SVR rates were only slightly higher for subjects with an absolute Hb decline >3 g/dL (44.3%, 493/1114) compared to those with maximum Hb declines <3 g/dL (40.2%, 296/737) (p=0.08). In contrast, a significant (p=0.0004) difference in SVR rates was obtained by comparing subjects with Hb declines >2 g/dL (44.6%, 673/1510) with those who experienced Hb declines <2 g/dL (34.0%, 116/341). Similar SVR rates of 46.1% (164/356) and 44.1% (509/1154) in patients with Hb declines >2 g/dL even if they did/did not become anemic (Hb<10 g/dL) strongly support Hb decline, and not anemia, as primary beneficial mechanism improving SVR. As summarized in the table, Hb declines >2 g/dl were significantly associated with higher SVR rates in difficult-to-treat patients, such as subjects elder than 50 years or subjects with high baseline viral load >600.000 IU/ml. Interestingly no beneficial effect was observed in patients with low platelet count (<150/nL), an indicator of advanced fibrosis/cirrhosis. Patients who first developed a Hb decline >2 g/dL during weeks 0-4 were likely to achieve similar SVR (41.3%, 365/883) than those who developed a Hb decline <2 g/dL (44.9%, 386/859). In contrast, a Hb decline >2 g/dL compared to <2 g/dL during weeks 0-4 was associated with a 2-3 fold higher risk of anemia in female (16.6% vs 40.5%) and male patients (7.3% vs 19.0%) when compared with a Hb decline <2 g/dL. Conclusions: Patients with HCV genotype 1 infection and in particular the subgroup of difficult-to-treat patients elder than 50 years or with HVL, achieve up to 15% higher SVR rates when they develop a Hb decline >2 g/dL during Peg2b/RBV therapy. However, patients with low platelet count <150/nL do not achieve this beneficial virologic effect.
( G Teuber ),( S Mauss ),( D Huppe ),( E Zehnter ),( M P Manns ),( T Dahhan ),( U Meyer ),( T Witthoft ),( B Moller ),( N Dikopoulos ),( J Brack ),( B Stade ),( M Bilzer ),( Bng Hepatitis Study Group 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background and Aims: Recently, it has been shown for the overall G1 population that anemia as well as the maximal hemoglobin (Hb) decline during peginterferon/RBV treatment is associated with higher SVR rates. We here investigated whether the maximal Hb decline influences SVR rates in difficult-to-treat patients undergoing Peg2b/RBV therapy for HCV G1 infection in real-life. Methods: Data of patients treated for G1 infection within the German Peg2b/RBV observational study were retrospectively analyzed. In this real-life cohort study G1 infection was treated with Peg2b 1.5 μg/kg/wk + weight-based RBV (800-1200 mg/day) for up to 48 wks at 285 sites. Subjects who discontinued for non-response or for any other reasons were included in the analysis. SVR was defined as undetectable serum HCV-RNA 24 wks after EOT response. Only one patient received erythropoietin treatment for anemia. Results: 1851 patients had baseline and at least one Hb measurement during therapy. Overall SVR rate was 42.6% (789/1851). SVR rates were only slightly higher for subjects with an absolute Hb decline >3 g/dL (44.3%, 493/1114) compared to those with maximum Hb declines <3 g/dL (40.2%, 296/737) (p=0.08). In contrast, a significant (p=0.0004) difference in SVR rates was obtained by comparing subjects with Hb declines >2 g/dL (44.6%, 673/1510) with those who experienced Hb declines <2 g/dL (34.0%, 116/341). Similar SVR rates of 46.1% (164/356) and 44.1% (509/1154) in patients with Hb declines >2 g/dL even if they did/did not become anemic (Hb<10 g/dL) strongly support Hb decline, and not anemia, as primary beneficial mechanism improving SVR. As summarized in the table, Hb declines >2 g/dl were significantly associated with higher SVR rates in difficult-to-treat patients, such as subjects elder than 50 years or subjects with high baseline viral load >600.000 IU/ml. Interestingly no beneficial effect was observed in patients with low platelet count (<150/nL), an indicator of advanced fibrosis/cirrhosis. Patients who first developed a Hb decline >2 g/dL during weeks 0-4 were likely to achieve similar SVR (41.3%, 365/883) than those who developed a Hb decline <2 g/dL (44.9%, 386/859). In contrast, a Hb decline >2 g/dL compared to <2 g/dL during weeks 0-4 was associated with a 2-3 fold higher risk of anemia in female (16.6% vs 40.5%) and male patients (7.3% vs 19.0%) when compared with a Hb decline <2 g/dL. Conclusions: Patients with HCV genotype 1 infection and in particular the subgroup of difficult-to-treat patients elder than 50 years or with HVL, achieve up to 15% higher SVR rates when they develop a Hb decline >2 g/dL during Peg2b/RBV therapy. However, patients with low platelet count <150/nL do not achieve this beneficial virologic effect.
Kim, Min Jeong,Ahn, Sol,Yi, Jigyoung,Hupp, Joseph T.,Notestein, Justin M.,Farha, Omar K.,Lee, Suk Joong Royal Society of Chemistry 2017 Catalysis Science & Technology Vol.7 No.19
<▼1><P>A Ni(ii) catalyst incorporated into a new porous organic polymer, Ni(ii)-POP-1, is prepared <I>via</I> a click reaction followed by metalation with NiCl2. It shows good catalytic activity for ethylene dimerization.</P></▼1><▼2><P>A Ni(ii) catalyst incorporated into a new porous organic polymer, Ni(ii)-POP-1, is prepared <I>via</I> a click reaction followed by metalation with NiCl2. It shows good catalytic activity for liquid-phase ethylene dimerization in the presence of Et2AlCl as a co-catalyst, generating 1-butene.</P></▼2>
The Emergence of the Conserved AAA+ ATPases Pontin and Reptin on the Signaling Landscape
Rosenbaum, Jean,Baek, Sung Hee,Dutta, Anindya,Houry, Walid A.,Huber, Otmar,Hupp, Ted R.,Matias, Pedro M. AAAS 2013 Science signaling Vol.6 No.266
<P>Pontin (also known as RUVBL1 and RVB1) and Reptin (also called RUVBL2 and RVB2) are related members of the large AAA+ (adenosine triphosphatase associated with diverse cellular activities) superfamily of conserved proteins. Various cellular functions depend on Pontin and Reptin, mostly because of their functions in the assembly of protein complexes that play a role in the regulation of cellular energetic metabolism, transcription, chromatin remodeling, and the DNA damage response. Little is known, though, about the interconnections between these multiple functions, how the relevant signaling pathways are regulated, whether the interconnections are affected in human disease, and whether components of these pathways are suitable targets for therapeutic intervention. The First International Workshop on Pontin (RUVBL1) and Reptin (RUVBL2), held between 16 and 19 October 2012, discussed the nature of the oligomeric organization of these proteins, their structures, their roles as partners in various protein complexes, and their involvement in cellular regulation, signaling, and pathophysiology, as well as their potential for therapeutic targeting. A major outcome of the meeting was a general consensus that most functions of Pontin and Reptin are related to their roles as chaperones or adaptor proteins that are important for the assembly and function of large signaling protein complexes.</P>
Lee, Chang Yeon,She, Chunxing,Jeong, Nak Cheon,Hupp, Joseph T. Royal Society of Chemistry 2010 Chemical communications Vol.46 No.33
<P>A π-extended porphyrin possessing two anchoring groups has been synthesized and successfully applied to dye-sensitized solar cells with a power conversion efficiency of 5.5%, rendering it comparable to the performance of N719-sensitized solar cells under the conditions employed here.</P> <P>Graphic Abstract</P><P>A π-extended porphyrin possessing two anchoring groups has been synthesized and successfully applied to dye-sensitized solar cells with a power conversion efficiency of 5.5%. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc00257g'> </P>
Bae, Youn-Sang,Farha, Omar K.,Spokoyny, Alexander M.,Mirkin, Chad A.,Hupp, Joseph T.,Snurr, Randall Q. Royal Society of Chemistry 2008 Chemical communications Vol.2008 No.35
<P>Separation of CO<SUB>2</SUB>/CH<SUB>4</SUB> mixtures was studied in carborane-based metal–organic framework materials with and without coordinatively unsaturated metal sites; high selectivities for CO<SUB>2</SUB> over CH<SUB>4</SUB> (∼17) are obtained, especially in the material with open metal sites.</P> <P>Graphic Abstract</P><P>A carborane-based metal–organic framework with coordinatively unsaturated metal sites yields high selectivities for CO<SUB>2</SUB> over CH<SUB>4</SUB> (∼17). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b805785k'> </P>
A Metal–Organic Framework-Based Material for Electrochemical Sensing of Carbon Dioxide
Gassensmith, Jeremiah J.,Kim, Jeung Yoon,Holcroft, James M.,Farha, Omar K.,Stoddart, J. Fraser,Hupp, Joseph T.,Jeong, Nak Cheon American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.23
<P>The free primary hydroxyl groups in the metal–organic framework of CDMOF-2, an extended cubic structure containing units of six γ-cyclodextrin tori linked together in cube-like fashion by rubidium ions, has been shown to react with gaseous CO<SUB>2</SUB> to form alkyl carbonate functions. The dynamic covalent carbon–oxygen bond, associated with this chemisorption process, releases CO<SUB>2</SUB> at low activation energies. As a result of this dynamic covalent chemistry going on inside a metal–organic framework, CO<SUB>2</SUB> can be detected selectively in the atmosphere by electrochemical impedance spectroscopy. The “as-synthesized” CDMOF-2 which exhibits high proton conductivity in pore-filling methanolic media, displays a ∼550-fold decrease in its ionic conductivity on binding CO<SUB>2</SUB>. This fundamental property has been exploited to create a sensor capable of measuring CO<SUB>2</SUB> concentrations quantitatively even in the presence of ambient oxygen.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2014/jacsat.2014.136.issue-23/ja5006465/production/images/medium/ja-2014-006465_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja5006465'>ACS Electronic Supporting Info</A></P>
Computational Screening of Nanoporous Materials for Hexane and Heptane Isomer Separation
Chung, Yongchul G.,Bai, Peng,Haranczyk, Maciej,Leperi, Karson T.,Li, Peng,Zhang, Hongda,Wang, Timothy C.,Duerinck, Tim,You, Fengqi,Hupp, Joseph T.,Farha, Omar K.,Siepmann, J. Ilja,Snurr, Randall Q. American Chemical Society 2017 Chemistry of materials Vol.29 No.15
<P>Computational high-throughput screening was carried out to assess a large number of-experimentally reported metal-organic frameworks (MOFs) and zeolites for their utility in hexane isomer separation. Through the work, we identified many MOFs and zeolites with high selectivity (SL+M > 10) for the group of n-hexane, 2-methylpentane, and 3-methylpentane (linear and monobranched isomers) versus 2,2-dimethylbutane and 2,3-dimethylbutane (dibranched isomers). This group of selective sorbents includes VICDOC (Fe-2(BDP)(3)), a MOF with triangular pores that is known to exhibit high isomer selectivity and capacity. For three of these structures, the adsorption isotherms for a 10-component mixture of hexane and heptane isomers were calculated. Subsequent simulations of column breakthrough curves showed that the DEYVUA MOF exhibits a longer process cycle time than VICDOC MOF or MRE zeolite, which are previously reported, high-performing materials, illustrating the importance of capacity in designing MOFs for practical applications. Among the identified candidates, we synthesized and characterized a MOF in a new copper form with high predicted adsorbent capacity (q(L+M) > 1.2 mol/L) and moderately high selectivity (SL+M approximate to 10). Finally, we examined the role of pore shape in hexane isomer separations, especially of triangular-shaped pores. We show through the potential energy surface and three-dimensional siting analyses that linear alkanes do not populate the corners of narrow triangular channels and that structures with nontriangular pores can efficiently separate hexane isomers. Detailed thermodynamic analysis illustrates how differences in the free energy of adsorption contribute to shape selective separation in nanoporous materials.</P>