A Case of Bullous Pemphigoid Arising in a Patient with Prurigo Nodularis

( Byeong Hak Seo ),( Dong Hee Kim ),( Jin Soo Kim ),( Yu Sung Choi ),( Ho Seok Suh ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.6

Facial flushing and erythema of rosacea improved by carvedilol

( Byeong Hak Seo ),( Yong Woo Oh ),( Dong Hee Kim ),( Ho Seok Suh ),( Yu Sung Choi ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Flushing and erythema are the most common symptoms of rosacea; however, management of these symptoms remains challenging. Recent studies suggest that treatment with carvedilol may reduce facial flushing and persistent erythema in the pathogenesis of rosacea. Objectives: To find the effect of carvedilol in the treatment of facial flushing and erythema in rosacea. Methods: Twenty-four rosacea patients treated with carvedilol for facial flushing and erythema were retrospectively reviewed. All patients were prescribed carvedilol 6.25 mg either once or twice per day, and the daily dose was gradually titrated up to 12.5 mg. Clinical erythema severity was assessed by the Clinician’s Erythema Assessment (CEA) and Patient’s Self-Assessment (PSA) scales. Improvement of CEA and PSA scores compared to the baseline were assessed. The proportion of patients with improvement of 2 or more points from baseline in CEA score was analyzed by sex, previous treatment exposure, disease duration, and subtypes. Results: The mean change of -1.6 in the CEA score and of -1.8 in the PSA score showed significant improvement from baseline. Erythematotelangiectatic rosacea (ETR) patients achieved more than 2-points improvement in the CEA score, compared with non-ETR patients. No statistically significant differences were observed by sex, disease duration, or previous treatment exposure. No serious adverse event was observed. Conclusion: Carvedilol can be an effective and safe treatment option for rosacea.

A case of desmoid tumor

( Byeong Hak Seo ),( Jin Soo Kim ),( Dong Hee Kim ),( Yu Sung Choi ),( Ho Seok Suh ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

A case of pseudoxanthomatous mastocytosis

( Byeong Hak Seo ),( Jin Soo Kim ),( Dong Hee Kim ),( Yu Sung Choi ),( Ho Seok Suh ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

A case of perforating pilomatricoma mimicking intradermal nevus on the scalp

( Byeong Hak Seo ),( Ji Hyun Kim ),( Yong Woo Oh ),( Dong Hee Kim ),( Ho Seok Suh ),( Yu Sung Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Pilomatricoma (calcifying epithelioma of Malherbe) is a relatively common benign skin tumor of childhood arising from the hair follicle matrix. There are several clinical variants of pilomatricoma, including, lymphangiectatic, anetodermic, pseudo-bullous and perforating form. Perforating pilomatricoma is a rare clinical subtype, and typically presents as an exophytic, crusted or ulcerated, erythematous to flesh-colored nodule on the head and neck. Histopathologically, it shows islands of cells composed of peripheral nucleated basaloid cells and central enucleated shadow cells in the dermis. Differential diagnosis includes trichoepithelioma, trichilemmal cyst, and intradermal nevus. The treatment of choice for pilomatricoma is surgical excision, and the recurrence rate is low. A 10-year old boy presented with 2-month history of a 0.6 x 0.5 cm sized, skin-colored to erythematous, protruding mass, without ulcer and crust, on the scalp. Excisional biopsy was done under the impression of intradermal nevus and histopathologic findings from the excised specimen showed a well-circumscribed tumor composed of enucleated eosinophlic cells surrounded by basaloid cells in the papillary dermis. The patient was diagnosed with perforating pilomatricoma. Herein, we report a case of perforating pilomatricoma mimiking intradermal nevus.

A case of generalized pseudoxanthoma elasticum

( Byeong Hak Seo ),( Ji Hyun Kim ),( Yong Woo Oh ),( Dong Hee Kim ),( Ho Seok Suh ),( Yu Sung Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Pseudoxanthoma elasticum (PXE) is a rare, genetic, multisystem disorder characterized by progressive calcification and degeneration of elastic fibers, involving skin, eyes and cardiovascular system. It is caused by mutations in ATP-binding cassette subfamily C member 6 (ABCC6) on chromosome 16q13.1. It clinically presents as yellowish, flat-topped, discrete, and confluent papules on the lateral neck, axillae, and flexural areas. Ocular angioid streaks, visual impairment, peau d’orange retinal hyperpigmentation are other diagnostic clues for PXE. Histopathologically, PXE shows swollen, clumped, fragmented elastic fibers with calcium deposits in the mid and deep reticular dermis. There is no specific treatment for PXE, but multidisciplinary approach is required for the systemic complications. A 49-year old man presented with generalized, confluent brownish patches on the trunk and skin-colored to yellowish, flat-topped, discrete papules on his neck since childhood. He was diagnosed with choroidal neovascularization with angioid streaks at the ophthalmology department 6 months ago. His sister also had similar cutaneous lesions. Histopathologic findings from neck and abdomen showed irregularly clumped, fragmented, bright pink-colored elastic fibers with degeneration in the dermis. Immunohistochemical staining was positive for elastic fibers. The patient was diagnosed with generalized PXE. Herein, we report a case of generalized PXE.

A case of simultaneous onset of congenital melanocytic nevus with halo phenomenon and vitiligo

( Byeong Hak Seo ),( Ji Hyun Kim ),( Yong Woo Oh ),( Dong Hee Kim ),( Yu Sung Choi ),( Ho Seok Suh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Halo nevus is a benign melanocytic nevus surrounded by a round, well-demarcated area of depigmentation. Halo phenomenon often occurs around acquired melanocytic lesions, including intradermal and compound nevi, Spitz nevus, malignant melanoma and congenital melanocytic nevus (CMN). Vitiligo is an acquired, autoimmune, depigmenting disorder of the skin and mucous membrane, resulting from a selective loss of melanocyte. The pathogenesis of halo nevus and vitiligo is still unclear, but a similar autoimmune mechanism of cytotoxic T-lymphocytes and autoantibodies to melanocytes has been suggested in both diseases. However, so far, simultaneous onset of CMN with halo phenomenon and vitiligo is rarely reported. A 6-year old boy presented with an annular whitish hypopigmented patch around a hairy pigmented plaque on the left knee and a coin-sized hypopigmented patch on the upper back. The hairy pigmented plaque appeared since birth and the depigmented patches appeared 6 months ago. Histopathologic findings from the central pigmented plaque showed nests of nevus cell, surrounded by lymphohistiocytic infiltrates in the dermis. The patient was diagnosed with CMN with halo phenomenon accompanied by vitiligo. Herein, we report a case of simultaneous onset of CMN with halo phenomenon and vitiligo.

A case of erythema multiforme-like drug eruption after taking Noni-powder

( Byeong Hak Seo ),( Ji Hyun Kim ),( Yong Woo Oh ),( Dong Hee Kim ),( Yu Sung Choi ),( Ho Seok Suh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Morinda citrifolia, also known as Noni, is a Polynesian plant with a long history of medicinal applications. Noni and its products are popular herbal dietary supplements globally used for preventive or therapeutic purposes in a variety of disease, including arthritis, diabetes and liver disease. However, no detailed pharmacological studies were reported on the putative active ingredients of the Noni, which include scopoletin and several volatile components. Recently, several cases of liver and kidney toxicities after taking Noni products have been reported, but there are limited data on cutaneous toxicity of Noni. A 35-year old woman presented with a sudden onset of erythematous, discrete papules on the elbow, knee and axilla for 5 days. She was on Noni powder for treatment of arthritis. There was no history of other drugs or signs of infection. Histopathologic findings showed spongiosis, exocytosis of the epidermis, papillary dermal edema and moderate to dense lymphohistiocytic cell infiltrates in the dermoepidermal junction. Parakeratosis with a few numbers of eosinophils were observed. Based on the clinical and histologic findings, the patient was diagnosed with erythema multiforme (EM)-like drug eruption and treated with topical steroids in addition to halting the previous noni powder. The lesions were improved within three weeks. Herein, we report a case of EM-like eruption after taking Noni-powder.

A case of unilateral facial vitiligo after bevacizumab

( Byeong Hak Seo ),( Ji Hyun Kim ),( Yong Woo Oh ),( Dong Hee Kim ),( Yu Sung Choi ),( Ho Seok Suh ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Vitiligo is a multifactorial, polygenic disorder, characterized by progressive autoimmune-mediated destruction of epidermal melanocytes. Its pathogenesis is still unclear, but various precipitating factors, including sun exposure, physical trauma, chemicals and drugs have been suggested. Bevacizumab is an anti-vascular endothelial growth factor (VEGF) monoclonal antibody approved for the treatment of colorectal, lung cancer, glioblastoma and melanoma. Cutaneous adverse reactions are common with bevacizumb, including exfoliative dermatitis, maculopapular rash, perforating dermatoses and acneiform eruptions. However, vitiligo induced by bevacizumab is rarely reported. A 27-year-old man presented with 4-day history of unilateral, well-circumscribed, hypopigmented patches on the right side of neck and chin. He had started bevacizumab therapy for colon cancer 1 month ago. In wood lamp examinations, well-demarcated, bright blue to whitish accentuation was observed. The patient was diagnosed with segmental vitiligo. He has been treated with the 311-nm titanium: sapphire laser third times a week for 7 months and hypopigmented patches were gradually improved. Herein, we present a case of unilateral facial vitiligo after bevacizumab.

『동의수세보원』 「사상인변증론」과 사상인의 마음론 고찰

임병학(Byeong-Hak Lim),윤수정(Su-Jeong Yun),서정숙(Jeong-Suk Seo) 한국인간과자연학회 2024 인간과자연 Vol.5 No.1

본 논문은 『동의수세보원』 제4권 마지막 장인 「사상인변증론」과 사상인의 마음작용을 고찰하였다. 「사상인변증론」은 태양인·태음인· 소양인·소음인의 성질(性質)과 체형·기상(氣像) 그리고 항상 있는 마음 등을 통해 사상인의 마음을 논하고 있다. 먼저 「사상인변증론」에서 논한 사상인의 성질을 보면, 태양인의 성질은 소통력이 있고 과감한 결단이 있어 훌륭한 리더로서의 자질을 갖추고 있다. 소양인의 성질은 표예효용(剽銳好勇)으로 말과 행동이 날래며 용맹한 성질이 있다. 태음인은 성취에 장점이 있고, 그 용모와 말솜씨 및 몸가짐은 거처함에 위의(威儀)가 있어서 공명정대한 성질이 있다. 소음인은 용모와 말하는 솜씨 및 몸가짐은 단정하고 진중하며 잔재주가 있다. 다음으로 사상인의 항상 있는 마음을 보면, 태음인은 항상 겁내는 마음(怯心)이 있어서, 밖을 살피지 못하고 두려운 마음(怕心)이 되면 정충증(怔忡症)에 이르게 되고, 소양인은 항상 두려운 마음(懼心)이 있어서 안을 살피지 못하고 공포심이 일면 건망증(健忘症)에 이르게 된다. 태음인과 소양인은 정기(情氣)의 작용인 락정기와 애정기를 안정시켜 마음을 편안하게 함으로써 병증을 치료할 수 있다. 또 소음인은 항상 불안정한 마음(不安定心)이 있고, 태양인은 항상 급박한 마음(急迫之心)이 있는데, 이는 성기(性氣)의 작용인 애성기와 락성기의 마음을 안정시킴으로써 불안하고 급박한 마음으로 인해 발생하는 병증을 다스릴 수 있다. 마지막으로 「사상인변증론」에서는 『황제내경』 오행인론이 사상의학과는 다른 체계임을 밝히고 있다. 하늘이 사람에게 품부한 장리(藏理)와 네 가지로 드러나는 장국(藏局)의 형성을 통해 사상인을 변별할 수 있는 방법을 찾을 수 있다. In this paper, examined the Sasangin apologetics which is in the last chapter of the forth volume of DonguiSuseBowon and the workings of sasangin’s maeum. Sasangin apologetics is discussed the details workings of sasangin’s maeum based on Taeyangin, Taeeumin, Soyangin, and Soeumin’s tempers somatotype, vigor, and the always maeum. First of all, regarding sasangin’s temper of Sasangin apologetics, Taeyangin includes effective communication skills and the ability to make bold decisions, possessing qualities of an excellent leader. The nature of a Soyangin is characterized by sharpness and bravery, displaying eloquence and courageous actions. A Taeumin excels in achievements, presenting an imposing appearance, refined speech, and dignified demeanor. A Soeumin carries a neat and serious appearance, eloquent speech, and dignified demeanor, along with pretty trick. Next, regarding Sasangin’s always maeum, Taeeumin has always fright(Geopsim) and gets palpitation when he doesnt’s look outside and get frightened, Soyangin has always fear(Gusim) and get amnesia when he doesnt’s not to look inside with horror. Taeeumin and Soyangin can be treated disease symptom to stable Joy Jeonggi and Sorrow Jeonggi of action of Jeonggi and take it easy. Soeumin is always uneasy and Taeyangin is always urgent, so they can be treated disease symptom caused by feeling urgent·uneasiness to stable Sorrow Seonggi and Joy Seonggi of action of Seonggi. we can find a way to discriminate sasangin through the formation of the Jangri(藏理) bestowed by heaven and the manifestation of the four Jangguk(藏局). Keywords: DonguiSuseBowon, Sasangin apologetics, Sasangin, temper·Jaekan(材幹), always maeum, Jangguk(藏局)