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RISS 인기검색어
- 검색키워드
- 저자 : ( Abul Kalam Najmi ) (검색결과 3 건)
- 무료
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( Md Salman Hussain ),( Abul Kalam Najmi ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.0
Purpose: Asthma is the most common respiratory disease affecting more than 350 million people worldwide. Epidemiological studies found an association between asthma and abdominal obesity. However, the published evidence presented conflicting findings. So, this study is aimed to assess the association between abdominal obesity and asthma. Method: A Literature search was performed in databases including PubMed, and Embase from inception to July 2019. Two investigators independently retrieved the literature, extracted the data and assess the study quality using the Newcastle-Ottawa Scale. The primary outcome was to assess the association between abdominal obesity and asthma. Secondary outcomes include subgroup analysis based on gender. Review Manager version 5.3 was used for the statistical analysis. Results: This meta-analysis was based on five cohort studies with a total of 39533 patients. Included studies were of high quality. Abdominal obesity was assessed based on the waist circumference in all the included studies. The pooled analysis found a significant positive association between abdominal obesity and asthma with an odds ratio of 1.66 (95% CI: 1.30 - 2.15), p= <0.0001 (Fig.1). Subgroup analysis based on the female population found a significant positive association between abdominal obesity and asthma with a pooled odds ratio of 1.30 (95% CI: 1.04 - 1.63), p= 0.02. Whereas, a non-significant association exists when the data were pooled for the male population with an odds ratio of 1.66 (95% CI: 0.78 - 3.52), p= 0.19. Conclusion: We found a positive association between abdominal obesity and asthma. Future large epidemiological studies are warranted to make the evidence more robust.
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Protective effect of silymarin in streptozotocin-induced diabetic dyslipidaemia in rats
Sharma, Manju,Pillai, K.K.,Anwer, Tarique,Najmi, Abul Kalam,Haque, Syed Ehtaishamul,Sultana, Yasmin Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.3
The present study investigated the effect of silymarin, a flavonoid, on streptozotocin (STZ) - induced diabetic dyslipidaemia in rats. Experimental diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Silymarin (25 mg/kg and 50 mg/kg) was orally administered to diabetic rats for a period of 15 days. Blood glucose levels, serum lipid profile and liver glycogen levels were estimated following the established procedures. Biochemical observations were supplemented with histological examination of liver sections. Oral administration of silymarin to diabetic rats significantly (P < 0.001) decreased the blood glucose levels ($259.99{\pm}23.64$ vs. $99.90{\pm}2.62$ [25 mg] & $89.17{\pm}3.32$ [50 mg]). The most interesting finding was the significant (p < 0.001) increase in HDL-cholesterol levels ($26.99{\pm}0.61$ vs. $40.55{\pm}0.52$ [25 mg] & $41.12{\pm}0.37$ [50 mg]) whereas, there was a significant decrease in serum total cholesterol (TCh), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) cholesterol levels observed in silymarin treated diabetic rats. STZ treatment caused significant degeneration of liver parenchyma, which was normalized to near normal morphology by administration of silymarin. The findings indicate that silymarin effectively improved the overall lipid profile and restored the glycogen stores in the liver of STZ-induced diabetic rats, in a dose dependent manner. The results indicate existence of abnormalities in lipid metabolism in STZ-induced diabetic rats and suggest a protective effect of silymarin in this animal model.
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Protective effect of silymarin in streptozotocin-induced diabetic dyslipidaemia in rats
Manju Sharma,K. K. Pillai,Tarique Anwer,Abul Kalam Najmi,Syed Ehtaishamul Haque,Yasmin Sultana 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.3
The present study investigated the effect of silymarin, a flavonoid, on streptozotocin (STZ) - induced diabetic dyslipidaemia in rats. Experimental diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). Silymarin (25 mg/kg and 50 mg/kg) was orally administered to diabetic rats for a period of 15 days. Blood glucose levels, serum lipid profile and liver glycogen levels were estimated following the established procedures. Biochemical observations were supplemented with histological examination of liver sections. Oral administration of silymarin to diabetic rats significantly (P < 0.001) decreased the blood glucose levels (259.99 ± 23.64 vs. 99.90 ±2.62 [25 mg] & 89.17 ± 3.32 [50 mg]). The most interesting finding was the significant (p < 0.001)increase in HDL-cholesterol levels (26.99 ± 0.61 vs. 40.55 ± 0.52 [25 mg] & 41.12 ± 0.37 [50 mg])whereas, there was a significant decrease in serum total cholesterol (TCh), triglycerides (TG), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) cholesterol levels observed in silymarin treated diabetic rats. STZ treatment caused significant degeneration of liver parenchyma,which was normalized to near normal morphology by administration of silymarin. The findings indicate that silymarin effectively improved the overall lipid profile and restored the glycogen stores in the liver of STZ-induced diabetic rats, in a dose dependent manner. The results indicate existence of abnormalities in lipid metabolism in STZ-induced diabetic rats and suggest a protective effect of silymarin in this animal model.
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