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Xu, Zhenming,Pone, Egest J.,Al-Qahtani, Ahmed,Park, Seok-Rae,Zan, Hong,Casali, Paolo CRC Press 2007 Critical reviews in immunology Vol.27 No.4
<P>Expression and activity of activation-induced cytidine deaminase (AID) encoded by the aicda gene are essential for immunoglobulin (Ig) gene somatic hypermutation (SHM) and class switch DNA recombination (CSR). SHM and CSR unfold, in general, in germinal centers and/are central to the maturation of effective antibody responses. AID expression is induced by activated B-cell CD40 signaling, which is critical for the germinal center reaction, and is further enhanced by other stimuli, including interleukin-4 (IL-4) secreted from CD4+ T cells or Toll-like receptor (TLR)-activating bacterial and/or viral molecules. Integration of different intracellular signal transduction pathways, as activated by these stimuli, leads to a dynamic aicda-regulating program, which involves both positively acting trans-factors, such as Pax5, HoxC4, E47, and Irf8, and negative modulators, such as Blimp1 and Id2, to restrict aicda expression primarily to germinal center B cells. The phosphatidylinositol 3-kinase (PI 3-K), which functions downstream of activated B-cell receptor (BCR) signaling, likely plays an important role in triggering the downregulation of aicda expression in postgerminal center B cells and throughout plasmacytoid differentiation. In B cells undergoing SHM and CSR, AID activity, and, possibly, AID targeting to the Ig locus are regulated at a posttranslational level, including AID dimerization/oligomerization, nuclear/cytoplasmic AID translocation, and phosphorylation of the AID Ser38 residue by protein kinase A (PKA). Here, we discuss the role of B-cell activation signals, transcription regulation programs, and posttranslational modifications in controlling aicda expression and AID activity, thereby delineating an integrated model of modulation of SHM and CSR in the germinal center reaction.</P>
Predicting Powder-Polymer Mixture Properties for PIM Design
Kate, K.H.,Enneti, R.K.,Park, S.-J.,German, R.M.,Atre, S.V. CRC PRESS LLC 2014 CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SCIE Vol.39 No.3
Powder injection molding (PIM) is a high-volume manufacturing technique for fabricating ceramic and metal components that have complex shapes. In PIM design, it is important to know the injection molding behavior at different powder-polymer compositions so as to understand the trade-offs between ease-of-fabrication, process throughput, and part quality at the design stage. A limited database of materials properties at different powder-polymer compositions is a significant challenge that needs to be addressed in order to conduct accurate computer simulations that aid part and mold design in PIM. However, accurate material property measurements are expensive and time-consuming. In order to resolve these conflicting challenges it is hypothesized that experimental measurements of material properties of a filled polymer at a specific filler content combined with similar measurements of unfilled polymer will be adequate to estimate the dependence of properties on filler content using rule-of-mixture models. To this end, this article focuses on a literature review of experimental data obtained from measurements of rheological, thermal, and mechanical properties for a wide range of powder-polymer mixtures at various filler volume fractions. The experimental data were compared to property estimates using various predictive models. It is expected that the current review will be valuable in selecting appropriate predictive models for estimating properties based on the input data requirements for commercially available mold-filling simulation platforms such as Moldflow (R) and PIMSolver (R). The combined protocol will be useful to design new materials and component geometries as well as optimize process parameters while eliminating expensive and time-consuming trial-and-error practices prevalent in PIM.
Finite-Element Analysis on the Stability of Geotextile Tube-Reinforced Embankments under Scouring
Kim, Hyeong-Joo,ASCE, A.M.,Won, Myoung-Soo,Jamin, Jay C. CRC Press, LLC 2015 International journal of geomechanics Vol.15 No.2
<P> Scouring is a significant problem on river bank and coastal protection systems. Severe scouring can cause damaging consequences to geotextile tube embankment structures. In this study, five case scenarios of an embankment system supported by stacked geotextile tubes were analyzed using a commercially available finite-element analysis software. These case scenarios include (1) conventional geotextile tube stacking on ground base foundation; (2) geotextile tube stacking on gravel bedding foundation; (3) geotextile tube stacking on excavated foundation; (4) geotextile tube stacking on excavated foundation with gravel bedding; and (5) fortification of stacked geotextile tubes by riprap protection. Each case scenario is simulated under normal loading and critical loading conditions with and without scouring at the base toe of the embankment system. Results suggest that the potential problems that occur during scouring and critical states of the embankment system instigate failures that could destabilize the geotextile tube retaining structure. Among all the case scenarios considered, additional fortification by riprap increases the performance and global stability of the geotextile tube embankment system. </P>
Applications of calcium and its supplement derived from marine organisms.
Kim, Se-Kwon,Ravichandran, Y Dominic,Kong, Chang-Suk CRC Press 2012 Critical reviews in food science and nutrition Vol.52 No.6
<P>Calcium, being an essential mineral with many important and diversified functions, plays an important role in the health and well being of the human. Marine organisms serve as an alternate source for calcium. Calcium has to be solubilized in the body in order to have the maximum benefits. The increased solubility of calcium from diet contributes to calcium absorption and bioavailability in the body. In this paper, we report various marine sources of calcium, solubilizing the calcium to improve the bioavailability and the applications of calcium as an important mineral in controlling different diseases.</P>