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Song, Kib-Beum,Na, Ji-Young,Oh, Myung-Hoon,Kim, Sok-Ho,Kim, Young-Ha,Park, Byung-Yong,Shin, Gi-Wook,Kim, Bum-Seok,You, Myung-Jo,Kwon, Jung-Kee Korean Society of ToxicologyKorea Environmental Mu 2012 Toxicological Research Vol.28 No.1
It has been shown that the accumulation of prion in the cytoplasm can result in neurodegenerative disorders. Synthetic prion peptide 106-126 (PrP) is a glycoprotein that is expressed predominantly by neurons and other cells, including glial cells. Prion-induced chronic neurodegeneration has a substantial inflammatory component, and an increase in the levels of matrix metalloproteinases (MMPs) may play an important role in neurodegenerative development and progression. However, the expression of MMPs in PrP induced rat astrocytes and microglia has not yet been compared. Thus, in this study, we examined the fluorescence intensity of CD11b positive microglia and Glial Fibrillary Acidic Protein (GFAP) positive astrocytes and found that the fluorescent intensity was increased following incubation with PrP at 24 hours in a dose-dependent manner. We also observed an increase in interleukin-1 beta (IL-$1{\beta}$) and tumor necrosis factor alpha (TNF-${\alpha}$) protein expression, which are initial inflammatory cytokines, in both PrP induced astrocytes and microglia. Furthermore, an increase MMP-1, 3 and 11 expressions in PrP induced astrocytes and microglia was observed by real time PCR. Our results demonstrated PrP induced activation of astrocytes and microglia respectively, which resulted in an increase in inflammatory cytokines and MMPs expression. These results provide the insight into the different sensitivities of glial cells to PrP.
Se Young Park,Hee Seok Moon,Jae Kyu Seong,정현용,Beum Yong Yoon,Se Woong Hwang,Kyu Sang Song 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.6
We report a rare case of a gastric plasmacytoma treated with endoscopic resection and oral thalidomide therapy. A 70-year-old man was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The patient was diagnosed with extramedullary gastric plasmacytoma. Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The patient’s condition was found to be stable.
Cho, Yongsoo,Lee, Kyo-Beum,Song, Joong-Ho,Lee, Young Il Institute of Electrical and Electronics Engineers 2015 IEEE transactions on power electronics Vol. No.
<P>This paper proposes a simple and effective method to reduce torque ripples for the torque predictive control (TPC) of permanent-magnet synchronous motors (PMSMs). The conventional TPC analyzes the relationship among the electrical torque, stator flux, and stator voltage using the magnitude of the stator voltage vector of PMSMs to obtain the angle of the reference voltage vector and accurately control the torque. In addition, the stator-flux control uses the hysteresis method. However, the voltage vector that can be chosen in an inverter is limited because the conventional TPC fixes the magnitude of the reference voltage vector, and thus, a large torque ripple is generated in the low-speed region. The proposed TPC does not fix but varies the magnitude of the reference voltage vector using both the torque and flux error information. Therefore, it not only has the fast dynamic of a direct torque control but also can reduce effectively the torque ripple. The proposed method is proven by the simulation and experimental results, and the proposed algorithm provides an excellent steady-state response and fast dynamics.</P>
High Performance Current Controller for Sparse Matrix Converter Based on Model Predictive Control
Lee, Eunsil,Lee, Kyo-Beum,Lee, Young Il,Song, Joong-Ho The Korean Institute of Electrical Engineers 2013 Journal of Electrical Engineering & Technology Vol.8 No.5
A novel predictive current control strategy for a sparse matrix converter is presented. The sparse matrix converter is functionally-equivalent to the direct matrix converter but has a reduced number of switches. The predictive current control uses a model of the system to predict the future value of the load current and generates the reference voltage vector that minimizes a given cost function so that space vector modulation is achieved. The results show that the proposed controller for sparse matrix converters controls the load current very effectively and performs very well through simulation and experimental results.
High Performance Current Controller for Sparse Matrix Converter Based on Model Predictive Control
Eunsil Lee,Kyo-Beum Lee,Young Il Lee,Joong-Ho Song 대한전기학회 2013 Journal of Electrical Engineering & Technology Vol.8 No.5
A novel predictive current control strategy for a sparse matrix converter is presented. The sparse matrix converter is functionally-equivalent to the direct matrix converter but has a reduced number of switches. The predictive current control uses a model of the system to predict the future value of the load current and generates the reference voltage vector that minimizes a given cost function so that space vector modulation is achieved. The results show that the proposed controller for sparse matrix converters controls the load current very effectively and performs very well through simulation and experimental results.