Rapid tumoritropic accumulation of systemically injected plateloid particles and their biodistribution

van de Ven, A.L.,Kim, P.,Haley, O.,Fakhoury, J.R.,Adriani, G.,Schmulen, J.,Moloney, P.,Hussain, F.,Ferrari, M.,Liu, X.,Yun, S.H.,Decuzzi, P. Elsevier Science Publishers 2012 Journal of controlled release Vol.158 No.1

Nanoparticles for cancer therapy and imaging are designed to accumulate in the diseased tissue by exploiting the Enhanced Permeability and Retention (EPR) effect. This limits their size to about 100nm. Here, using intravital microscopy and elemental analysis, we compare the in vivo localization of particles with different geometries and demonstrate that plateloid particles preferentially accumulate within the tumor vasculature at unprecedented levels, independent of the EPR effect. In melanoma-bearing mice, 1000x400nm plateloid particles adhered to the tumor vasculature at about 5% and 10% of the injected dose per gram organ (ID/g) for untargeted and RGD-targeted particles respectively, and exhibited the highest tumor-to-liver accumulation ratios (0.22 and 0.35). Smaller and larger plateloid particles, as well as cylindroid particles, were more extensively sequestered by the liver, spleen, and lungs. Plateloid particles appeared well-suited for taking advantage of hydrodynamic forces and interfacial interactions required for efficient tumoritropic accumulation, even without using specific targeting ligands.

Hairy Nanocellulose

Theo van de Ven 한국펄프·종이공학회 2016 한국펄프·종이공학회 학술발표논문집 Vol.2016 No.10

STELLAR KINEMATICS AND STRUCTURAL PROPERTIES OF VIRGO CLUSTER DWARF EARLY-TYPE GALAXIES FROM THE SMAKCED PROJECT. II. THE SURVEY AND A SYSTEMATIC ANALYSIS OF KINEMATIC ANOMALIES AND ASYMMETRIES

Toloba, E.,Guhathakurta, P.,Peletier, R. F.,Boselli, A.,Lisker, T.,Falcó,n-Barroso, J.,Simon, J. D.,van de Ven, G.,Paudel, S.,Emsellem, E.,Janz, J.,den Brok, M.,Gorgas, J.,Hensler, G.,Laurikaine IOP Publishing 2014 The Astrophysical journal Supplement series Vol.215 No.2

<P>We present spatially resolved kinematics and global stellar populations and mass-to-light ratios for a sample of 39 dwarf early-type (dE) galaxies in the Virgo cluster studied as part of the SMAKCED stellar absorption-line spectroscopy and imaging survey. This sample is representative of the early-type population in the Virgo cluster in the absolute magnitude range -19.0 < M-r < -16.0 and of all morphological subclasses found in this galaxy population. For each dE, we measure the rotation curve and velocity dispersion profile and fit an analytic function to the rotation curve. We study the significance of the departure of the rotation curve from the best-fit analytic function (poorly fit) and of the difference between the approaching and receding sides of the rotation curve (asymmetry). Our sample includes two dEs with kinematically decoupled cores that have been previously reported. We find that 62 +/- 8% (23 out of the 39) of the dEs have a significant anomaly in their rotation curve. Analysis of the images reveals photometric anomalies for most galaxies. However, there is no clear correlation between the significance of the photometric and kinematic anomalies. We measure age-sensitive (H-beta and H-gamma A) and metallicity sensitive (Fe4668 and Mgb) Lick spectral indices in the LIS-5 angstrom system. This population of galaxies exhibits a wide range of ages and metallicities; we also find that 4 dEs show clear evidence of emission partially filling in the Balmer absorption lines. Finally, we estimate the total masses and dark matter fractions of the dEs and plot them in the mass-size, themass-velocity dispersion, and the fundamental plane scaling relations. The dEs seem to be the bridge between massive early-type galaxies and dSphs, and have a median total mass within the R-e of logM(e) = 9.1 +/- 0.2 and a median dark matter fraction within the R-e of f(DM) = 46 +/- 18%. Any formation model for the dE galaxy class must account for this diversity of kinematic and photometric anomalies and stellar populations.</P>

Health-Care Providers' Perspectives towards Childhood Cancer Treatment in Kenya

Njuguna, F,Burgt, RHM van der,Seijffert, A,Musimbi, J,Langat, S,Skiles, J,Sitaresmi, MN,Ven, PM van de,Kaspers, GJL,Mostert, S Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: This study explored perspectives of health-care providers on childhood cancer treatment in Kenya. Materials and Methods: A self-administered questionnaire was completed by 104 health-care providers in January and February 2013. Results: Seventy six percent of the health-care providers believed cancer to be curable. More doctors than other health-care providers had this positive opinion (p=0.037). The majority of health-care providers (92%) believed that most children with cancer will not be able to finish their treatment due to financial difficulties. They considered that prosperous highly-educated parents adhere better with treatment (88%) and that doctors adhere better with treatment for prosperous highly-educated parents (79%). According to 74% of health-care providers, quality of care is better for prosperous highly-educated parents (74%). Most health-care providers reported giving more explanation (71%), work with greater accuracy (70%) and use less difficult vocabulary (55%) to prosperous more educated families. Only 34% of health-care providers reported they feel more empathy towards patients from prosperous families. Reasons for non-adherence with the protocol according to health-care providers are: family refuses drugs (85%), inadequate supply of drugs at pharmacy (79%), child looks ill (75%), and financial difficulties of parents (69%). Conclusions: Health-care providers' health beliefs and attitudes differ for patients with families having high versus low socio-economic backgrounds.

[Keynote Speeches] RETENTION AIDS:FROM ART TO SCIENCE

Theo G.M,van de Ven 한국펄프·종이공학회 1999 한국펄프종이학회 기타 간행물 Vol.- No.-

Our knowledge about the mechanisms by which retention aids function in wet-end papermaking has been increasing rapidly. Although originally many retention aids were introduced without little understanding of how they act, nowadays a clear scientific understanding is emerging. We can say that the use of retention aids has passed from an art which depended much on experience and intuition, to a science, which involves the principles of colloid and polymer science. Various examples of our increased understanding of PEO-based retention. aids, cationic. poly-and microparticulate retention aid systems are being discussed.

Socio-economic Status Plays Important Roles in Childhood Cancer Treatment Outcome in Indonesia

Mostert, Saskia,Gunawan, Stefanus,Wolters, Emma,van de Ven, Peter,Sitaresmi, Mei,van Dongen, Josephine,Veerman, Anjo,Mantik, Max,Kaspers, Gertjan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: The influence of parental socio-economic status on childhood cancer treatment outcome in low-income countries has not been sufficiently investigated. Our study examined this influence and explored parental experiences during cancer treatment of their children in an Indonesian academic hospital. Materials and Methods: Medical charts of 145 children diagnosed with cancer between 1999 and 2009 were reviewed retrospectively. From October 2011 until January 2012, 40 caretakers were interviewed using semi-structured questionnaires. Results: Of all patients, 48% abandoned treatment, 34% experienced death, 9% had progressive/relapsed disease, and 9% overall event-free survival. Prosperous patients had better treatment outcome than poor patients (P<0.0001). Odds-ratio for treatment abandonment was 3.3 (95%CI: 1.4-8.1, p=0.006) for poor versus prosperous patients. Parents often believed that their child's health was beyond doctor control and determined by luck, fate or God (55%). Causes of cancer were thought to be destiny (35%) or God's punishment (23%). Alternative treatment could (18%) or might (50%) cure cancer. Most parents (95%) would like more information about cancer and treatment. More contact with doctors was desired (98%). Income decreased during treatment (55%). Parents lost employment (48% fathers, 10% mothers), most of whom stated this loss was caused by their child's cancer (84% fathers, 100% mothers). Loss of income led to financial difficulties (63%) and debts (55%). Conclusions: Treatment abandonment was most important reason for treatment failure. Treatment outcome was determined by parental socio-economic status. Childhood cancer survival could improve if financial constraints and provision of information and guidance are better addressed.

Parents' and Health-Care Providers' Perspectives on Side-Effects of Childhood Cancer Treatment in Indonesia

Gunawan, Stefanus,Wolters, Emma,Dongen, Josephine Van,De Ven, Peter Van,Sitaresmi, Mei,Veerman, Anjo,Mantik, Max,Kaspers, Gertjan,Mostert, Saskia Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: Efficacy of childhood cancer treatment in low-income countries may be impacted by parents' and health-care providers' perspectives on chemotherapy-related side-effects. This study explores prevalence and severity of side-effects in childhood cancer, and compares health beliefs about side-effects between parents and health-care providers, and between nurses and doctors in Indonesia. Materials and Methods: Semi-structured questionnaires were filled in by 40 parents and 207 health-care providers in an academic hospital. Results: Parents exporessed a desire to receive more information about side-effects (98%) and worried about this aspect of treatment (90%), although side-effects were less severe than expected (66%). The most frequent was behavior alteration (98%) and the most severe was hair loss. Only 26% of parents consulted doctors about side-effects. More parents, compared to health-care providers, believed that medicines work better when side-effects are more severe (p<0.001), and accepted severe side-effects (p=0.021). More health-care providers, compared to parents, believed that chemotherapy can be stopped or the dosage altered when there are side-effects (p=0.011). More nurses, compared to doctors, stated that side-effects were unbearable (p=0.004) and made them doubt efficacy of treatment (p<0.001). Conclusions: Behavior alteration is the most frequent and hair loss the most severe side-effect. Apparent discrepancies in health beliefs about side-effects exist between parents and health-care providers. A sustainable parental education program about side-effects is recommended. Health-care providers need to update and improve their knowledge and communication skills in order to give appropriate information. Suchmeasures may improve outcome of childhood cancer treatment in low-income countries, where adherence to therapy is a major issue.

Parental Experiences with Chemotherapy-Induced Alopecia among Childhood Cancer Patients in Indonesia

Gunawan, Stefanus,Broeke, Chloe ten,Ven, Peter van de,Arnoldussen, Marijn,Kaspers, Gertjan,Mostert, Saskia Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Background: This study assessed parental experiences with chemotherapy-induced alopecia among children with cancer treated at an Indonesian academic hospital. Materials and Methods: Fifty parents of childhood cancer patients were interviewed using semi-structured questionnaires. Results: The moment that hair fell out was the moment that parents (84%) had to admit their child had cancer. Alopecia was a traumatizing painful experience (46%). Active strategies to hide alopecia, mainly hats, were used by 66% of children, while 34% never covered their bald head. If money had not been an issue, 40% would use another strategy. Alopecia made children limit outdoor daily activities (78%) and engagement with others (60%). Significantly more children from high-educated (95%) than low-educated (60%) parents received sympathy from other people (P=0.012). Significantly more Christian (29%) than Muslim (0%) families confirmed that alopecia lowered the quality of life (P=0.046). Most parents (82%) had no prior plans about alopecia management, yet for significantly more girls (26%) than boys (0%) such plans existed (P=0.044). Parents received most information about alopecia from other parents (66%). Parents (92%) needed more alopecia education from doctors. Of all school-attending children, 53% were bullied and 47% did not want to attend school due to alopecia. Significantly more high-educated than low-educated families received pity from teachers and pupils (94% vs. 0%, P=0.004), and acceptance by pupils (81% vs. 0%, P=0.021). Conclusions: Alopecia is a severe, far-stretching side-effect of chemotherapy with physical, psychological and social consequences for children and parents. Parents should be better informed about occurrence and impact of alopecia. Extra attention is required to facilitate children's return to school. Healthcare providers should facilitate optimal supportive care through open dialogue and provision of educational m aterials for parents, children and their community.

The SAURON project – XIX. Optical and near‐infrared scaling relations of nearby elliptical, lenticular and Sa galaxies

Falcó,n‐,Barroso, J.,van de Ven, G.,Peletier, R. F.,Bureau, M.,Jeong, H.,Bacon, R.,Cappellari, M.,Davies, R. L.,de Zeeuw, P. T.,Emsellem, E.,Krajnović,, D.,Kuntschner, H.,McDermid, R. Blackwell Publishing Ltd 2011 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.417 No.3

<P><B>ABSTRACT</B></P><P>We present ground‐based MDM Observatory <I>V</I>‐band and <I>Spitzer</I>/InfraRed Array Camera 3.6‐<IMG src='/wiley-blackwell_img/equation/MNR_19372_mu1.gif' alt ='inline image'/>m‐band photometric observations of the 72 representative galaxies of the SAURON survey. Galaxies in our sample probe the elliptical E, lenticular S0 and spiral Sa populations in the nearby Universe, both in field and cluster environments. We perform aperture photometry to derive homogeneous structural quantities. In combination with the SAURON stellar velocity dispersion measured within an effective radius (σ<SUB>e</SUB>), this allows us to explore the location of our galaxies in the colour–magnitude, colour–σ<SUB>e</SUB>, Kormendy, Faber–Jackson and Fundamental Plane scaling relations. We investigate the dependence of these relations on our recent kinematical classification of early‐type galaxies (i.e. slow/fast rotators) and the stellar populations. Slow rotator and fast rotator E/S0 galaxies do not populate distinct locations in the scaling relations, although slow rotators display a smaller intrinsic scatter. We find that Sa galaxies deviate from the colour–magnitude and colour–σ<SUB>e</SUB> relations due to the presence of dust, while the E/S0 galaxies define tight relations. Surprisingly, extremely young objects do not display the bluest (<I>V</I>−[3.6]) colours in our sample, as is usually the case in optical colours. This can be understood in the context of the large contribution of thermally pulsing asymptotic giant branch stars to the infrared, even for young populations, resulting in a very tight (<I>V</I>−[3.6])–σ<SUB>e</SUB> relation that in turn allows us to define a strong correlation between metallicity and σ<SUB>e</SUB>. Many Sa galaxies appear to follow the Fundamental Plane defined by E/S0 galaxies. Galaxies that appear offset from the relations correspond mostly to objects with extremely young populations, with signs of ongoing, extended star formation. We correct for this effect in the Fundamental Plane, by replacing luminosity with stellar mass using an estimate of the stellar mass‐to‐light ratio, so that all galaxies are part of a tight, single relation. The new estimated coefficients are consistent in both photometric bands and suggest that differences in stellar populations account for about half of the observed tilt with respect to the virial prediction. After these corrections, the slow rotator family shows almost no intrinsic scatter around the best‐fitting Fundamental Plane. The use of a velocity dispersion within a small aperture (e.g. <I>R</I><SUB>e</SUB>/8) in the Fundamental Plane results in an increase of around 15 per cent in the intrinsic scatter and an average 10 per cent decrease in the tilt away from the virial relation.</P>

Health-Care Providers' and Parents' Perspectives on Complementary Alternative Medicine in Children with Cancer in Indonesia

Susilawati, Dwi,Sitaresmi, Mei,Handayani, Krisna,Ven, Peter van de,Sutaryo, Sutaryo,Kaspers, Gertjan,Mostert, Saskia Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

Background: Complementary alternative medicine (CAM) use in children with cancer is widespread. Health-care providers (HCP) need to acknowledge and address this need. This study explored and compared perspectives on CAM of HCP and parents of young patients with cancer in Indonesia. Materials and Methods: We conducted a cross-sectional study using semi-structured questionnaires in HCP and parents of childhood cancer patients at an Indonesian academic hospital. Results: A total of 351 respondents participated: 175 HCP (response rate 80%) and 176 parents (response rate 80%). Parents were more likely than HCP to think that chemotherapy can cure cancer (80% compared to 69%, P=0.013). Nearly half of all parents (46%) and HCP (45%) doubted whether CAM can cure cancer. Parents were more likely than HCP to think that CAM can be helpful in childhood cancer treatment (54% compared to 35%, P=0.003). The most recommended CAM by HCP was self-prayer (93%). Reasons for recommending CAM were: hope for improvement of the child's condition (48%), patient wants to stop treatment (42%). Most discouraged CAM by HCP was by old-smart people (70%), the reasons being: lack of evidence for usefulness (77%), lack of CAM knowledge (75%). The proportion thinking that patients were unlikely to raise the CAM topic if they perceived that doctors were skeptical was higher in parents than in HCP (52% versus 1%) (P<0.001). Most HCP (71%) and parents (77%) acknowledged that their knowledge about safety and efficacy of CAM was inadequate (P=ns). The proportion that wanted to learn or read more about CAM was higher among parents than HCP (48% compared to 31%, P=0.002). Conclusions: HCP and parents have different perspectives on CAM use in children with cancer. HCP should enhance their CAM knowledge and encourage open communication about CAM with parents. If doctors' skepticism is perceived, parents are unlikely to raise CAM as a topic.