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- 저자 : majid abrishami (검색결과 3 건)
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Comparison between Tear Film Osmolar Cocentration and Other Tear Film Function Parameters
akbar derakhshan,arash omidtabrizi,majid abrishami,mohamad khajedaluee,somayeh ghassemi moghaddam 대한안과학회 2019 Korean Journal of Ophthalmology Vol.33 No.4
Purpose: To evaluate tear film function in patients with diabetes mellitus (DM) using tear film osmolarity (TFO)measurements compared to other tear film function tests. Methods: DM patients without any history of ocular surface disorder but with potential effects on the tear filmwere enrolled in this cross-sectional study. Data including dry eye symptoms, duration of DM, stage of diabeticretinopathy and blood hemoglobin A1c levels were recorded. Tear film break-up time (TBUT) and basic tearsecretion (Schirmer test) were assessed. TFO was determined using the Tearlab Osmolarity System. The outcomemeasures were the difference between the mean values of TBUT, basic tear secretion and TFO in boththe study and control groups. Results: We recruited 51 DM patients and 20 control subjects with a mean age of 51.2 (range, 21 to 70) and48.5 (range, 24 to 70) years, respectively. A total of 27 patients (53%) and 11 controls (55%) reported dry eyesymptoms (p = 0.668). The mean TBUT was 10.2 + 4.8 seconds in the study group versus 10.5 + 2.8 secondsin controls, which was not significantly different (p = 0.747). The mean Schirmer test score was 8.1 + 4.3 mmin the patients versus 10.1 + 3.0 mm in the controls (p = 0.069). The mean TFO was 294.1 + 12.9 mosmol/Lin the patients versus 291.4 + 14.5 mosmol/L in the controls (p = 0.456). It was significantly higher in patientswith poor glycemic control determined by hemoglobin A1c > 8% (p = 0.003). TFO had a positive correlationwith the duration of DM (p = 0.030) but not with the stage of diabetic retinopathy (p = 0.944). However, TFOshowed a significant relationship with dry eye symptoms (p = 0.001). Conclusions: TFO is impaired in patients with uncontrolled DM and is better correlated with glycemic controland dry eye symptoms than the TBUT and Schirmer tests.
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Bilateral Macular Hole Following Myopic Photorefractive Keratectomy
Nasser Shoeibi,Mohammad Hossein Jabbarpoor Bonyadi,Majid Abrishami,Mohammad-reza Ansari-Astaneh 대한안과학회 2014 Korean Journal of Ophthalmology Vol.28 No.3
A 42-year-old man was admitted to our clinic complaining of visual distortion in his left eye two monthsafter bilateral myopic photorefractive keratectomy (PRK). Macular optical coherence tomography (OCT)showed a stage II macular hole in the left eye. Simultaneous OCT in the right eye showed vitreous tractionand distortion of the outer retina. One month later, the patient underwent vitrectomy for the left eye, andthe macular hole was closed. Two months after that, the patient complained of visual distortion in the righteye, and OCT revealed increased traction and accentuated outer retinal distortion indicating a stage IBmacular hole. Traction attenuated later without any intervention. The short interval between PRK and holeformation, bilateral involvement, and the moderate refractive error in this case highlight the possible role ofPRK in aggravating vitreoretinal interface abnormalities. We recommend the addition of PRK to the list ofprocedures that may be associated with the formation of a macular hole.
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Masood Naseripour,Bizhan Malaekeh-Nikouei,Majid Abrishami,Ahad Sedaghat,Mojtaba Abrishami,Mozhgan Rezaei Kanavi,Navid Mosallaei,Khalil Ghasemi Falavarjani,Rama Pourmatin,Omid Safarian 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.6
The aim of present study was to evaluate the stability and toxicity of different doses of liposomal melphalan in rabbit eyes and to investigate the pathological and electrophysiological changes after administration of different doses of free form of melphalan. Liposomes containing melphalan were prepared by solvent evaporation method and mean size of these liposomes and encapsulation efficacy of nanoliposomes were determined. In albino rabbits, intravitreal injections of 10, 20, and 40 lg doses of liposomal melphalan and Alkeran as the commercial product was performed. The rabbits were euthanized at days 2, 7, 14, and 28, and the eyes were enucleated. Vitreous and aqueous samples and electrophysiological recordings were obtained before euthanization. Histological examination was performed after enucleation. Particle size of prepared liposomes was 143.6 ± 3.2 nm. Liposomes have protected melphalan completely from any undesirable release or hydrolysis for 48 h. In a histopathological study, signs of retinal toxicity were found in all doses in the liposomal group at least at one time point during the study. In melphalan injected eyes, histopathological toxicity was found in the 40 lg dose. Extensive variability was found in electrophysiological recordings, and significant waveform changes were found in all injected eyes at least on one occasion during the study. Intraocular administration of liposomal melphalan cannot prolong the drug clearance time of this drug in the vitreous humor. In the 40 lg injected eyes, significant retinal atrophic changes were detected in all eyes throughout the study, and electrophysiological results were consistent with histopathological findings.
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