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- 저자 : chaudhari kiran nanaji (검색결과 2 건)
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김경준,chaudhari kiran nanaji,김신익,김연호,신권수 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.95 No.-
We report a facile single-step synthesis approach for the development of reduced graphene oxide (rGO)supported copper nanoparticles, which can also perform as a peroxidase enzyme mimicking catalyst. Theentire synthesis procedure uses a single reducing agent to reduce graphene oxide and the copperprecursor at a relatively lower temperature of 70 C to generate the Cu-rGO composite, where coppernanoparticles are homogenously decorated on the rGO surface. Morphological and structural analysisshows that the crinkled structure of the rGO protects the copper nanoparticles from excessive oxidationand results in the development of a stable Cu-rGO composite. The as-prepared Cu-rGO composite wasstudied for its efficacy to perform as a peroxidase mimic by catalyzing the oxidation of 3,30,5,50-tetramethylbenzidine (TMB), a peroxidase substrate in the presence of hydrogen peroxide. Cu-rGO wassuccessfully able to catalyze hydrogen peroxide and oxidation reaction of TMB followed by a color change. Our results indicate that the Cu-rGO composite has a largely unexplored potential for application in thedevelopment of hybrid sensing and detection systems for hydrogen peroxide, which can also be appliedfor glucose detection.
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Evaluation of Toxicity and Gene Expression Changes Triggered by Oxide Nanoparticles
Pooja Dua,김소연,유종성,홍선우,Nitin K. Chaudhari,Chang Han Lee,chaudhari kiran nanaji,Dong-ki Lee 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.6
Several studies have demonstrated that nanoparticles (NPs) have toxic effects on cultured cell lines, yet there are no clear data describing the overall molecular changes induced by NPs currently in use for human applications. In this study, the in vitro cytotoxicity of three oxide NPs of around 100 nm size, namely,mesoporous silica (MCM-41), iron oxide (Fe_2O_3-NPs), and zinc oxide (ZnO-NPs), was evaluated in the human embryonic kidney cell line HEK293. Cell viability assays demonstrated that 100 μg/mL MCM-41, 100 μg/mL Fe_2O_3, and 12.5 μg/mL ZnO exhibited 20% reductions in HEK293 cell viability in 24 hrs. DNA microarray analysis was performed on cells treated with these oxide NPs and further validated by real time PCR to understand cytotoxic changes occurring at the molecular level. Microarray analysis of NP-treated cells identified a number of up- and down-regulated genes that were found to be associated with inflammation,stress, and the cell death and defense response. At both the cellular and molecular levels, the toxicity was observed in the following order: ZnO-NPs > Fe_2O_3-NPs > MCM-41. In conclusion, our study provides important information regarding the toxicity of these three commonly used oxide NPs, which should be useful in future biomedical applications of these nanoparticles
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