http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The long non-coding RNA uc.4 influences cell differentiation through the TGF-beta signaling pathway
Zijie Cheng,Qijun Zhang,Anwen Yin,Mengwen Feng,Hua Li,Hailang Li,Yun Li,Lingmei Qian 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
In a previous study, we screened thousands of long non-coding RNAs (lncRNAs) to assess their potential relationship with congenital heart disease (CHD). In this study, uc.4 attracted our attention because of its high level of evolutionary conservation and its antisense orientation to the CASZ1 gene, which is vital for heart development. We explored the function of uc.4 in cells and in zebrafish, and describe a potential mechanism of action. P19 cells were used to investigate the function of uc.4. We studied the effect of uc.4 overexpression on heart development in zebrafish. The overexpression of uc.4 influenced cell differentiation by inhibiting the TGF-beta signaling pathway and suppressed heart development in zebrafish, resulting in cardiac malformation. Taken together, our findings show that uc.4 is involved in heart development, thus providing a potential therapeutic target for CHD.
Wang Xinjun,Cheng Peng,Xie Jinwei,Zhou Zijie 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.8
The present paper investigated the enhancement of moisture-separation efficiency for ordinary special crossunder pipe separators(SCRUPSs) and proposed three structure-modified separators (combined separator, Z-shaped SCRUPSs, and spiral-type SCRUPSs). Deposition mechanisms for droplets with different sizes were considered using commercial CFD flow solver. Results show that threestructuremodified separators can increase droplet deposition rate to varying degrees. Regarding flow losses, spiral-type SCRUPSs causethe highest increase, with a total pressure loss coefficient of 231%, although it has the best deposition rate improvement. Among the threestructure-modified separators, "Z" shape separator has the best separation performance because of its higher moisture-separation efficiencyand lower total pressure loss efficiency. Results could provide theoretical basis for research on and development of this new typeof moisture separator.