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Safaei-Ghomi, Javad,Ziarati, Abolfazl,Teymuri, Raheleh Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
A simple one-pot synthesis of two derivatives of 1,4-dihydropyridines has been described under reflux conditions using copper iodide nanoparticles (CuI NPs) as a catalyst in high yields. This method demonstrated four-component coupling reactions of aldehydes and ammonium acetate via two pathways. In one route, the reaction was performed using 2 eq ethyl acetoacetate while in the other one 1 eq ethyl acetoacetate and 1 eq malononitrile were used. The CuI NPs was reused and recycled without any loss of activity and product yield. It is noteworthy to state that wide range of the 1,4-dihydropyridines have attracted large interest due to pharmacological and biological activities.
Javad Safaei-Ghomi,Abolfazl Ziarati,Raheleh Teymuri 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.8
A simple one-pot synthesis of two derivatives of 1,4-dihydropyridines has been described under reflux conditions using copper iodide nanoparticles (CuI NPs) as a catalyst in high yields. This method demonstrated four-component coupling reactions of aldehydes and ammonium acetate via two pathways. In one route, the reaction was performed using 2 eq ethyl acetoacetate while in the other one 1 eq ethyl acetoacetate and 1 eq malononitrile were used. The CuI NPs was reused and recycled without any loss of activity and product yield. It is noteworthy to state that wide range of the 1,4-dihydropyridines have attracted large interest due to pharmacological and biological activities.
Stefani Frost,Parisa Ziarati,Ryan Moen,Lynn Kysh,Robert Johnson,Shane Pearce,Siamak Daneshmand,Kimberly D. Siegmund,Victoria K. Cortessis 대한비뇨기종양학회 2024 대한비뇨기종양학회지 Vol.22 No.1
Purpose: Diabetes mellitus, a frequent comorbid condition in cancer patients, has been shown to increase risk of all-site cancer mortality. This relationship has not been systematically studied in bladder cancer patients. This systematic review and meta-analysis aimed to identify, evaluate, and synthesize available evidence on the relationship between history of diabetes and outcomes in bladder cancer patients. Materials and Methods: Systematic searches interrogated OVID MEDLINE, Embase, Web of Science, Google Scholar, and Cochrane Library to identify scholarly reports relating diabetes to all-cause mortality, bladder cancer-specific mortality, recurrence, and progression in bladder cancer patients. After critical review, metaanalysis was used to quantitively synthesize qualifying data and assess potential influence of publication bias, clinical heterogeneity, and residual confounding. Results: We synthesized data on over 226,472 patients treated with curative intent uniquely represented in 28 studies that met quality metrics. Having diabetes was positively associated with each outcome. Hazard ratio estimates were indistinguishable for mortality from any cause, 1.22 (95% confidence interval [CI], 1.12–1.33) and bladder cancer-specific mortality, 1.28 (95% CI 1.17–1.41) and notably stronger in patients with muscle-invasive and high-risk non–muscle-invasive bladder cancer, 1.32 (95% CI, 1.15–1.50) and 1.48 (95% CI, 1.06–2.06). Neither publication bias, systematic error, nor confounding by factors such as smoking or obesity is likely to explain the observed associations. Conclusions: Bladder cancer patients with diabetes experience elevated mortality that is not explained by diabetes-related comorbidities or complications. Future research should explore type, severity, and duration of diabetes in relation to unfavorable bladder cancer outcomes.
Alebouyeh, Farzaneh,Bidgoli, Sepideh Arbabi,Ziarati, Parisa,Heshmati, Masoomeh,Qomi, Mahnaz Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Diseases related to water impurities may present as major public health burdens. The present study aimed to assess the mutagenicity of drinking water from different zones of Tehran, and evaluate possible health risks through making tea with tea bags, by Ames mutagenicity test using TA 100, TA 98 and YG1029 strains. For this purpose, 450 water samples were collected over the period of July to December 2014 from 5 different zones of Tehran. Except for one sample, no mutagenic potential was detected during these two seasons and the MI scores were almost normal (${\leq}1-1.6$) in TA 100, TA 98 and YG1029 strains. Although no mutagenic effects were considered in TA 98 and TA 100 in the test samples of our three evaluated tea bag brands, one sample from a local company showed mutagenic effects in the YG1029 strain (MI=1.7-1.9 and 2) after prolonged (10-15 min.) steeping. Despite the mild mutagenic effect discovered for one of the brand, this cross sectional study showed relative safety of water samples and black tea bags in Tehran. According to the sensitivity of YG1029 to the mutagenic potential of water and black tea, even without metabolic activation by s9 fraction, this metabolizer strain could be considered as sensitive and applicable to food samples for quantitative analysis of mutagens.
Seyed Mehdi Dehghan,Mohammad Amir Najafgholipour,Seyed Mohsen Ziarati,Mohammad Reza Mehrpour 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.26 No.3
Built-up Double-I (BD-I) columns consist of two hot rolled IPE sections and two cover plates which are welded by fillet welds. In Iran, this type of column is commonly used in braced frames with simple connections and sometimes in low-rise Moment Resisting Frames (MRF) with Welded Flange Plate (WFP) beam-column detailing. To evaluate the seismic performance of WFP connection of I-beam to BD-I column, traditional and modified exterior MRF connections were tested subjected to cyclic prescribed loading of AISC. Test results indicate that the traditional connection does not achieve the intended behavior while the modified connection can moderately meet the requirements of MRF connection. The numerical models of the connections were developed in ABAQUS finite element software and validated with the test results. For this purpose, moment-rotation curves and failure modes of the tested connections were compared with the simulation results. Moreover to avoid improper failure modes, some improvements of the connections were evaluated through a numerical study.