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Xu Zi Guang,Jyung-Sik Kwak,Ki Wan Oh,배한익,한진이 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1
The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of evan’s blue dye after subcutaneous injection of LPS (30 μg site-1). Dye leakage in the skin was significantly increased 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that PHCP pretreatment inhibited MDA elevation and the remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants such as trolox and mannitol and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis were detected between 24 h and 72 h after LPS injection (30, 100 μg site-1), compared to control animals after the injection of saline. This increase was greater in mice treated with 100 μg of mice than those of the 30 μg of mice and was significantly suppressed by pretreatment with PHCP, antioxidants and HO-1 inhibitor. These results collectively suggest that PHCP has anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.
Biomedical Application of PHBV/Collagen (PHCP) Nanofiber as the Wound Dressing
Xu Zi Guang,문찬미,곽정식,오기완,배한익,한진이 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.3
In this study, a nanofibrous scaffold was obtained by co-electrospinning poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and collagen in 2,2,2-trifluoroethanol at a ratio of 3/7. The fiber diameters were in the range of 250-600 nm. It was found that PHBV/Collagen (PHCP) nanofibrous scaffold more proliferated than on the PHBV nanofibrous scaffold induced by oxidant in NIH3T3 cells. Otherwise, on the early-stage wound-healing mouse model, wound closure was evaluated by wound size reduction and histology of the regenerated skin on the back of mouse. An each of tissues removed on 0, 3, 6, 9, 12, 15 and 18 day were used to analyse biochemical and pathological changes. Every nanofiber-attached mice showed no significant difference to the 3th day, but from the third day until the nineth day, PHCP-attached mice were found to heal much faster than that of control wounds in epithelialisation, wound contraction and histopathological examinations. These results strongly support the beneficial effects of the biomedical application of PHCP nanofiber in the acceleration of wound healing initial phase through α-SM actin contraction.
Xu, Ting,Xu, Zi-Cheng,Zou, Qin,Yu, Bin,Huang, Xin-En Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Objective: Individual studies of the associations between P53 codon 72 polymorphism (rs1042522) and bladder cancer susceptibility have shown inconclusive results. To derive a more precise estimation of the relationship, we performed this systemic review and meta-analysis based on 15 publications. Methods: We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Results: We found that there was no association between P53 codon 72 polymorphism and bladder cancer risk in the comparisons of Pro/Pro vs Arg/Arg; Pro/Arg vs. Arg/Arg; Pro/Pro plus Pro/Arg vs. Arg/Arg; Arg/Arg vs. Pro/Arg plus Arg/Arg (OR=1.06 95%CI 0.81-1.39; OR=1.06 95%CI 0.83-1.36; OR=0.98 95%CI 0.78-1.23; OR=1.06 95%CI 0.84-1.32). However, a significantly increased risk of bladder cancer was found among Asians in the homozygote comparison (Pro/Pro vs. Arg/Arg, OR=1.36 95%CI 1.05-1.75, P=0.790 for heterogeneity) and the dominant model (Arg/Pro plus Pro/Pro vs. Arg/Arg, OR=1.26 95%CI 1.05-1.52, P=0.564 for heterogeneity). In contrast, no evidence of an association between bladder cancer risk and P53 genotype was observed among Caucasian population in any genetic model. When stratifying for the stage of bladder, no statistical association were found (Pro/Pro vs. Arg/Arg, OR=0.45 95%CI 0.17-1.21; Pro/Arg vs. Arg/Arg, OR=0.60 95%CI 0.28-1.27; Dominant model, OR=0.56 95%CI 0.26-1.20; Recessive model, OR=0.62 95%CI0.35-1.08) between P53 codon 72 polymorphism and bladder cancer in all comparisons. Conclusions: Despite the limitations, the results of the present meta-analysis suggest that, in the P53 codon 72, Pro/Pro type and dominant mode might increase the susceptibility to bladder cancer in Asians; and there are no association between genotype distribution and the stage of bladder cancer.
Zi-Xiang Xu,Joo-Chang Park,Hueon Namkung,Li-Hua Xu,Hyung-Taek Kim 한국열환경공학회 2019 한국열환경공학회 학술대회지 Vol.2019 No.춘계
The co-combustion of low-rank coal with biomass is regarded as a prospective technology for reducing CO2 emissions to mitigate the issues related to the excess global warming. However, the ash deposition and fine particle formations problems were severe with the addition of biomass. Therefore, it is vital to investigate ash deposition and fine particle formation to ensure the normal operation of equipment in thermal power plant and improve thermal conversion efficiency as well as protect air environment. In this study, two types of raw coals (Berau coal, Bayan coal) and three types of hybrid coals (Berau coal impregnated with 10 wt%, 20 wt% molasses; and Bayan coal impregnated with 3 wt% molasses) are used as the samples to conduct DTF experiment. The propensity associated with ash deposition and fine particle formation are studied at excess air under combustion temperature of 1300℃. The ash deposits generated at the probe top surface maintained at 800℃, and the fine particles carried by the flue gas were collected by the filter paper. A range of analytical techniques including SEM-EDX and XRD were used to analyze the morphology and elemental distribution of ash deposits and fine particles for clarifying the ash deposits behavior. It is found that the deposition tendency of 3% HCK is lower than other fuels. As far as the fine particle formation is concerned, the contents of Si and Al in coarse particles were apparently higher than those in fine particle. S and K is higher in fine particles.
Yuan, Zi-Xu,Ma, Teng-Hui,Zhong, Qing-Hua,Wang, Huai-Ming,Yu, Xi-Hu,Qin, Qi-Yuan,Chu, Li-Li,Wang, Lei,Wang, Jian-Ping Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Radiation proctitis is a common complication after radiotherapy for pelvic malignant tumors. This study was conducted to assess the efficacy of novel almagate enemas in hemorrhagic chronic radiation proctitis (CRP) and evaluate risk factors related to rectal deep ulcer or fistula secondary to CRP. All patients underwent a colonoscopy to confirm the diagnosis of CRP and symptoms were graded. Typical endoscopic and pathological images, risk factors, and quality of life were also recorded. A total of 59 patients were enrolled. Gynecological cancers composed 93.1% of the primary malignancies. Complete or obvious reduction of bleeding was observed in 90% (53/59) patients after almagate enema. The mean score of bleeding improved from 2.17 to 0.83 (P<0.001) after the enemas. The mean response time was 12 days. No adverse effects were found. Moreover, long-term successful rate in controlling bleeding was 69% and the quality of life was dramatically improved (P=0.001). The efficacy was equivalent to rectal sucralfate, but the almagate with its antacid properties acted more rapidly than sucralfate. Furthermore, we firstly found that moderate to severe anemia was the risk factor of CRP patients who developed rectal deep ulcer or fistulas (P= 0.015). We also found abnormal hyaline-like thick wall vessels, which revealed endarteritis obliterans and the fibrosis underlying this disease. These findings indicate that almagate enema is a novel effective, rapid and well-tolerated method for hemorrhagic CRP. Moderate to severe anemia is a risk factor for deep ulceration or fistula.