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변화하는 혈압의 영향을 받지 않는 동맥 벽의 강화도 측정 방법 제안 : 대동맥 확장지수
서지혜,최동호,오수경,이종민,Seo, Jee-Hye,Choi, Dong-Ho,Wu, Zhuqing,Rienmueller, Rainer,Lee, Jong-Min 대한의용생체공학회 2008 의공학회지 Vol.29 No.2
To evaluate aortic wall stiffness without influence of different background blood pressure, a new technique was developed and verified. At eight swine descending aortae, volume-pressure measurement was performed using custom-made system. Based on averaged pressure-volume curve, aortic distensibility index was formulated to evaluate aortic wall stiffness regardless of variable blood pressure and aortic size. The variability of aortic distensibility index by pressure change was compared with other parameters for wall stiffness evaluation. Subsequently, the aortic distensibility index was calculated at 100 contrast-enhanced EBCT data sets of normal volunteers in regular health screening program. The measured aortic distensibility index was compared with age, coronary calcium score, and aortic calcium score. Between 50 and 360 mmHg of blood pressure, the coefficient of variance of aortic distensibility index was 22.00% as comparing with 88.99% of classical compliance. Based on age, aortic distensibility index showed correlation coefficient of 0.55, whereas classical compliance showed 0.26. The correlation coefficient with modified aortic calcification was 0.43. Linear regression study revealed statistical significance of correlation coefficients. The aortic distensibility index, the method to evaluate aortic wall stiffness free from variable blood pressure and aortic size, was developed and verified with significant practical feasibility.
Sungsic Bang,Jeehye Seo,Teaho Kim,Dongho Choi,Zhuqing Wu,Jongmin Lee,Jinho Jo 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
Acquiring real-time microscopic images directly from laboratory animals is technically difficult. Fluorescencemediated observation of blood vessels and developing tumors is particularly challenging. We developed a titanium and polyethylene tissue window to observe under the skin and evaluated the feasibility of this approach in a rat model. The prerequisites of the tissue window were absence of foreign body reaction, high physical strength, and reduced invasiveness. Foreign body reaction was monitored for 1 week following installation on the back of each animal. Following the injection of fluorescent material, subcutaneous venous flow, tumor neovascularization flow, and cerebral surface vascular flow could be imaged using the tissue window.