Damage identification of vehicle-track coupling system from dynamic responses of moving vehicles

Zhu, Hong-Ping,Ye, Ling,Weng, Shun,Tian, Wei Techno-Press 2018 Smart Structures and Systems, An International Jou Vol.21 No.5

The structural responses are often used to identify the structural local damages. However, it is usually difficult to gain the responses of the track, as the sensors cannot be installed on the track directly. The vehicles running on a track excite track vibration and can also serve as response receivers because the vehicle dynamic response contains the vibration information of the track. A damage identification method using the vehicle responses and sensitivity analysis is proposed for the vehicle-track coupling system in this paper. Different from most damage identification methods of vehicle-track coupling system, which require the structural responses, only the vehicle responses are required in the proposed method. The local damages are identified by a sensitivity-based model updating process. In the vehicle-track coupling system, the track is modeled as a discrete point supported Euler-Bernoulli beam, and two vehicle models are proposed to investigate the accuracy and efficiency of damage identification. The measured track irregularity is considered in the calculation of vehicle dynamic responses. The measurement noises are also considered to study their effects to the damage identification results. The identified results demonstrate that the proposed method is capable to identify the local damages of the track accurately in different noise levels with only the vehicle responses.

Potential Mechanisms of Benzyl Isothiocyanate Suppression of Invasion and Angiogenesis by the U87MG Human Glioma Cell Line

Zhu, Yu,Zhang, Ling,Zhang, Guo-Dong,Wang, Hong-Ou,Liu, Ming-Yan,Jiang, Yuan,Qi, Li-Sha,Li, Qi,Yang, Ping Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Glioma is one of the most common tumors in China and chemotherapy is critical for its treatment. Recent studies showed that benzyl isothiocyanate (BITC) could inhibit the growth of glioma cells, but the mechanisms are not fully understood. This study explored the inhibitory effect of BITC on invasion and angiogenesis of U87MG human glioma cells in vitro and in vivo, as well as potential mechanisms. It was found that BITC could inhibit invasion and angiogenesis of human glioma U87MG cells by inducing cell cycle arrest at phase G2/M. It also was demonstrated that BITC decreased expression of cyclin B1, p21, MMP-2/9, VE-cadherin, CD44, CXCR4 and MTH1, the activity of the telomerase and $PKC{\zeta}$ pathway. Microarray analysis was thus useful to explore the potential target genes related to tumorigenic processes. BITC may play important roles in the inhibition of invasion and angiogenesis of human glioma cells.

Aromatic Compounds from the Halotolerant Fungal Strain of Wallemia sebi PXP-89 in a Hypersaline Medium

Xiao-Ping Peng,Wei-Ming Zhu,Yi Wang,Pei-Pei Liu,Kui Hong,Hao Chen,Xia Yin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.6

A new cyclopentanopyridine alkaloid, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (1), together with 11 known aromatic compounds were isolated from the secondary metabolites of the halotolerant fungal strain Wallemia sebi PXP-89 in 10% NaCl. Their structures including the absolute configurations of (2S,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (2), (2R,3S)-1-(4-hydroxyphenyl)butane-2,3-diol (3), and (S)-3-hydroxy-4-(4-hydroxyphenyl)-2-one (4) were elucidated by spectroscopic analysis and a modified Mosher’s method. Compound 1 exhibited antimicrobial activity against Enterobacter aerogenes with a MIC of 76.7 μM. The absolute configurations of compounds 2-4 were determined for the first time.

Conventional Ultrasonography and Real Time Ultrasound Elastography in the Differential Diagnosis of Degenerating Cystic Thyroid Nodules Mimicking Malignancy and Papillary Thyroid Carcinomas

Wu, Hong-Xun,Zhang, Bing-Jie,Wang, Jun,Zhu, Bei-Lin,Zang, Ya-Ping,Cao, Yue-Long Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Background: To evaluate the diagnostic utility of conventional ultrasonography and real time ultrasound elastography in differentiating degenerating cystic thyroid nodules mimicking malignancy from papillary thyroid carcinoma. Methods: We retrospectively analyzed conventional ultrasonographic and elastographic characteristics of 19 degenerating cystic thyroid nodules mimicking malignancy in 19 patients, with 30 surgically confirmed PTCs as controls. Based on size, the nodules had been grouped into less than 10mm (group A) and greater than 10 mm (group B). We evaluated conventional parameters and elasticity pattern. Color-scaled elastograms were graded as to stiffness of nodules using an elasticity pattern from I (soft) to IV (stiff). Results: Degenerating cystic thyroid nodules were similar to PTCs in conventional ultrasonographic findings, but the former frequently showed oval to round in shape (group A, 69.2% vs 18.8%, P=0.017; group B, 66.7% vs 7.14%, P=0.017) and punctuate hyperechoic foci (group A, 61.5% vs 0, P<0.001; group B, 50% vs 0, P<0.001). On real time ultrasound elastography, 7 of 13 degenerating cystic thyroid nodules in group A were pattern I, 5 were pattern II, 1 was pattern III. One degenerating cystic thyroid nodule in group B was pattern II, 5 were pattern III. The area under the curve for elastography was 0.98 in group A (sensitivity 92.3%, specificity 100%, P = 0.002), and 0.88 in group B (sensitivity 16.7%, specificity 100%, P = 0.014). Conclusions: As a dependable imaging technique, elastography helps increase the performance in differential diagnosis of degenerating cystic thyroid nodule and malignancy.

MiR-454 Prompts Cell Proliferation of Human Colorectal Cancer Cells by Repressing CYLD Expression

Liang, Hong-Liang,Hu, Ai-Ping,Li, Sen-Lin,Xie, Jia-Ping,Ma, Qing-Zhu,Liu, Ji-Yong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Previous studies have shown that miR-454 plays an important role in a variety of biological processes in various human cancer cells. However, the underlying mechanisms of this microRNA in colorectal cancer (CRC) cells remain largely unknown. In the present study, we investigated the miR-454 role in CRC cell proliferation. We found that miR-454 expression is markedly upregulated in CRC tissues and CRC cells compared with the matched tumor adjacent tissues and the FHC normal colonic cell line. Ectopic expression of miR-454 promoted the proliferation and anchorage-independent growth of CRC cells, whereas inhibition of miR-454 reduced this effect. Bioinformatics analysis further revealed cylindromatosis (CYLD), a putative tumor suppressor as a potential target of miR-454. Data from luciferase reporter assays showed that miR-454 directly binds to the 3'-untranslated region (3'-UTR) of CYLD mRNA and repressed expression at both transcriptional and translational levels. In functional assays, CYLD-silenced in miR-454-in-transfected SW480 cells have positive effect to promote cell proliferation, suggesting that direct CYLD downregulation is required for miR-454-induced CRC cell proliferation. In sum, our data provide compelling evidence that miR-454 functions as an onco-miRNA, playing a crucial role in the promoting cell proliferation in CRC, and its oncogenic effect is mediated chiefly through direct suppression of CYLD expression.

Electromagnetic energy harvesting from structural vibrations during earthquakes

Songye Zhu,Wenai Shen,Hong-Ping Zhu,You-Lin Xu 국제구조공학회 2016 Smart Structures and Systems, An International Jou Vol.18 No.3

Energy harvesting is an emerging technique that extracts energy from surrounding environments to power low-power devices. For example, it can potentially provide sustainable energy for wireless sensing networks (WSNs) or structural control systems in civil engineering applications. This paper presents a comprehensive study on harvesting energy from earthquake-induced structural vibrations, which is typically of low frequency, to power WSNs. A macroscale pendulum-type electromagnetic harvester (MPEH) is proposed, analyzed and experimentally validated. The presented predictive model describes output power dependence with mass, efficiency and the power spectral density of base acceleration, providing a simple tool to estimate harvested energy. A series of shaking table tests in which a single-storey steel frame model equipped with a MPEH has been carried out under earthquake excitations. Three types of energy harvesting circuits, namely, a resistor circuit, a standard energy harvesting circuit (SEHC) and a voltage-mode controlled buck-boost converter were used for comparative study. In ideal cases, i.e., resistor circuit cases, the maximum electric energy of 8.72 J was harvested with the efficiency of 35.3%. In practical cases, the maximum electric energy of 4.67 J was extracted via the buck-boost converter under the same conditions. The predictive model on output power and harvested energy has been validated by the test data.

Circulating Low Absolute CD4+ T Cell Counts May Predict Poor Prognosis in Extranodal NK/T-Cell Lymphoma Patients Treating with Pegaspargase-Based Chemotherapy

Ya-Ping Zhang,Run Zhang,Hua-Yuan Zhu,Li Wang,Yu-Jie Wu,Jin-Hua Liang,Wen-Yu Shi,Hong Liu,Wei Xu,Jian-Yong Li 대한암학회 2019 Cancer Research and Treatment Vol.51 No.1

Purpose Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is a rare subtype of non- Hodgkin lymphoma, and asparaginase-based regimens are the best first-line treatments. Data on the role of specific circulating lymphocyte subsets in the progression of ENKTL are limited. The aim of this study was to investigate the clinical correlation and distribution of circulating absolute CD4+ T-cell counts (ACD4Cs) in ENKTL. Materials and Methods We retrospectively searched medical records for 70 newly diagnosed ENKTL patients treated with pegaspargase-based regimens. Comparison of ACD4Cs as a continuous parameter in different groups was calculated. Univariate and multivariate analyses were used to assess prognostic factors for overall survival (OS) and progression-free survival (PFS). Results Stage III/IV, B symptoms, elevated lactate dehydrogenase, monocytopenia, high-intermediate and high risk International Prognostic Index (IPI) and Korean Prognostic Index (KPI), high risk Prognostic Index of Natural Killer Lymphoma (PINK), and lower lymphocytes were significantly associated with low ACD4C at diagnosis. With a median follow-up time of 32 months, patients who had an ACD4C < 0.30109/L had a worse OS. Median OS was 11 months and median PFS was 5 months in the low ACD4C cohort. There were significant differences in both OS and PFS between the two cohorts. Moreover, multivariate Cox analysis identified ACD4Cs as an independent predictor for OS and PFS. Conclusion Low ACD4Cs were associated with poorer survival and could act as a negative predictor for ENKTL patients treated with asparaginase-based regimens.

Survivin Gene Functions and Relationships between Expression and Prognosis in Patients with Nasopharyngeal Carcinoma

Cai, Jun-Hong,Fu, Sheng-Miao,Tu, Zhi-Hua,Deng, Li-Qun,Liang, Zhu,Chen, Xin-Ping,Gong, Xuan-Ju,Wan, Li-Hua Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

This study aimed to investigate the relationship between prognosis and protein and mRNA expression of an apoptotic inhibitor gene, survivin, in patients with nasopharyngeal carcinoma. Furthermore, functions of the survivin gene in the CNE2 nasopharyngeal carcinoma cell line were assessed. Immunohistochemistry and in situ hybridization were used in detecting the survivin protein and mRNA in 44 nasopharyngeal carcinoma specimens, and 30 chronic nasopharyngitis samples as controls. Survivin gene expression in CNE2 cell line was suppressed with an shRNA (short hairpin RNA). The positive ratios of expression for survivin protein and mRNA in nasopharyngeal carcinoma were 79.5% and 75.0% respectively, obviously higher than in the control group (p<0.01), and there is very good consistency between the two methods. The mean survival time of patients with higher survivin protein or mRNA expression was shorter than in patients with lower levelsv(p<0.01). Proliferation of the CNE2 cell line was distinctly inhibited by the shRNA. The results indicate that overexpression of the survivin gene plays an important role in onset and development of nasopharyngeal carcinoma, and it may be helpful for prognostic appraisal.

Finite-time Boundness of H∞ Filtering for Switching Discrete-Time Systems

Jun Cheng,Hong Zhu,Shouming Zhong,Yu-Ping Zhang 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.6

For switched discrete-time systems, switching behavior always affect the finite-time stability property, which was neglected by most previous research. This paper investigated the problem of finite-time boundness of H∞ filtering for switched discrete-time systems. Sufficient conditions which can ensure finite-time bounded and H∞ filtering finite-time boundness under arbitrary switching are derived. Based on the results of finite-time boundness and stochastic character, the closed-loop system trajectory stays within a prescribed bound. An example is given to illustrate the efficiency of the proposed method.

Damage assessment of shear connectors with vibration measurements and power spectral density transmissibility

Jun Li,Hong Hao,Yong Xia,Hong-ping Zhu 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.54 No.2

Shear connectors are generally used to link the slab and girders together in slab-on-girderbridge structures. Damage of shear connectors in such structures will result in shear slippage between theslab and girders, which significantly reduces the load-carrying capacity of the bridge. Because shearconnectors are buried inside the structure, routine visual inspection is not able to detect conditions of shearconnectors. A few methods have been proposed in the literature to detect the condition of shear connectorsbased on vibration measurements. This paper proposes a different dynamic condition assessment approachto identify the damage of shear connectors in slab-on-girder bridge structures based on power spectraldensity transmissibility (PSDT). PSDT formulates the relationship between the auto-spectral densities oftwo responses in the frequency domain. It can be used to identify shear connector conditions with or withoutreference data of the undamaged structure (or the baseline). Measured impact force and accelerationresponses from hammer tests are analyzed to obtain the frequency response functions at sensor locations byexperimental modal analysis. PSDT from the slab response to the girder response is derived with theobtained frequency response functions. PSDT vectors in the undamaged and damaged states can becompared to identify the damage of shear connectors. When the baseline is not available, as in most practicalcases, PSDT vectors from the measured response at a reference sensor to those of the slab and girder in thedamaged state can be used to detect the damage of shear connectors. Numerical and experimental studies ona concrete slab supported by two steel girders are conducted to investigate the accuracy and efficiency of theproposed approach. Identification results demonstrate that damages of shear connectors are identifiedaccurately and efficiently with and without the baseline. The proposed method is also used to evaluate theconditions of shear connectors in a real composite bridge with in-field testing data.