The G801A Polymorphism in the CXCL12 Gene and Risk of Breast Carcinoma: Evidence from a Meta-Analysis Including 2,931 Subjects

Xia, Yong,Guo, Xu-Guang,Ji, Tian-Xing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

More and more evidence indicates that the G801A polymorphism in the CXCL12 gene might be associated with susceptibility to breast carcinoma in humans being. However, individually published results have been inconsistent. The purpose of this meta-analysis was to investigate the association between the G801A polymorphism in the CXCL12 gene and breast carcinoma risk. A complete search strategy was done by the electronic databases including PubMed and Chinese Biomedical Literature Database. A meta-analysis including seven individual studies was carried out in order to explore the association between the G801A polymorphism in the CXCL12 gene polymorphisms and breast carcinoma. The pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95%CIs) between the G801A polymorphism in the CXCL12 gene and breast carcinoma risk were assessed by the random-effects model. A significant relationship between the G801A polymorphism in the CXCL12 gene and breast carcinoma was discovered in an allelic genetic model (OR: 1.214, 95%CI: 1.085-1.358, p=0.001), a homozygote model (OR: 1.663, 95%CI: 1.240-2.232, p=0.001), a heterozygote model (OR: 1.392, 95%CI: 1.190-1.629, p=0.000), a recessive genetic model (OR: 1.407, 95%CI: 1.060-1.868, p=0.018) and a dominant genetic model (OR: 1.427, 95%CI: 1.228-1.659, p=0.000). On sub-group analysis based on ethnicity, significance was observed between the European group and the mixed group. A significant relationship was found between the G801A polymorphism in the CXCL12 gene and breast carcinoma risk. Individuals with the A allele of the G801A polymorphism in the CXCL12 gene are under a higher risk for breast carcinoma.

Iterative Learning Consensus Control for Multi-agent Systems with Fractional Order Distributed Parameter Models

Yong-Hong Lan,Jun-Jun Xia,Ya-Ping Xia,Peng Li 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.11

This paper concerns about the iterative learning consensus control scheme for a class of multi-agent systems (MAS) with distributed parameter models. First, based on the framework of network topologies, a secondorder iterative learning control (ILC) protocol is proposed by using the nearest neighbor knowledge. Next, a discrete system for ILC is established and the consensus control problem is then converted to a stability problem for such a discrete system. Furthermore, by using generalized Gronwall inequality, a sufficient condition for the convergence of the consensus errors between any two agents is obtained. Finally, the validity of the proposed method is verified by two numerical examples.

Measurement of rivulet movement and thickness on inclined cable using videogrammetry

Yong Xia,Haiquan Jing,You-Lin Xu,Yong-Le Li 국제구조공학회 2016 Smart Structures and Systems, An International Jou Vol.18 No.3

Stay cables in some cable-stayed bridges suffer large amplitude vibrations under the simultaneous occurrence of rain and wind. This phenomenon is called rain–wind-induced vibration (RWIV). The upper rivulet oscillating circumferentially on the inclined cable surface plays an important role in this phenomenon. However, its small size and high sensitivity to wind flow make measuring rivulet size and its movement challenging. Moreover, the distribution of the rivulet along the entire cable has not been measured. This paper applies the videogrammetric technique to measure the movement and geometry dimension of the upper rivulet along the entire cable during RWIV. A cable model is tested in an open-jet wind tunnel with artificial rain. RWIV is successfully reproduced. Only one digital video camera is employed and installed on the cable during the experiment. The camera records video clips of the upper rivulet and cable movements. The video clips are then transferred into a series of images, from which the positions of the cable and the upper rivulet at each time instant are identified by image processing. The thickness of the upper rivulet is also estimated. The oscillation amplitude, equilibrium position, and dominant frequency of the rivulet are presented. The relationship between cable and rivulet variations is also investigated. Results demonstrate that this non-contact, non-intrusive measurement method has good resolution and is cost effective.

Sulforaphane Inhibits Nonmuscle Invasive Bladder Cancer Cells Proliferation through Suppression of HIF-1α-Mediated Glycolysis in Hypoxia

Xia, Yong,Kang, Taek Won,Jung, Young Do,Zhang, Chao,Lian, Sen American Chemical Society 2019 Journal of agricultural and food chemistry Vol.67 No.28

<P>Bladder cancer is the fourth common cancer among men and more than 70% of the bladder cancer is nonmuscle invasive bladder cancer (NMIBC). Because of its high recurrence rate, NMIBC brings to patients physical agony and high therapy costs to the patients’ family and society. It is imperative to seek a natural compound to inhibit bladder cancer cell growth and prevent bladder cancer recurrence. Cell proliferation is one of the main features of solid tumor development, and the rapid tumor cell growth usually leads to hypoxia due to the low oxygen environment. In this study we found that sulforaphane, a natural chemical which was abundant in cruciferous vegetables, could suppress bladder cancer cells proliferation in hypoxia significantly stronger than in normoxia (<I>p</I> < 0.05): 20 μM sulforaphane inhibited bladder cancer cell proliferation by 26.1 ± 4.1% in normoxia, while it inhibited cell proliferation by 39.7 ± 5.2% in hypoxia in RT112 cells. Consistently, sulforaphane inhibited cell proliferation by 29.7 ± 4.6% in normoxia, while it inhibited cell proliferation by 48.3 ± 5.2% in hypoxia in RT4 cells. Moreover, we revealed that sulforaphane decreased glycolytic metabolism in a hypoxia microenvironment by downregulating hypoxia-induced HIF-1α and blocking HIF-1α trans-localization to the nucleus in NMIBC cell lines. This study discovered a food sourced compound inhibiting bladder cancer cells proliferation and provided experimental evidence for developing a new bladder cancer preventive and therapeutic strategy.</P> [FIG OMISSION]</BR>

Calculation of eigenvalue and eigenvector derivatives with the improved Kron's substructuring method

Xia, Yong,Weng, Shun,Xu, You-Lin,Zhu, Hong-Ping Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.36 No.1

For large-scale structures, the calculation of the eigensolution and the eigensensitivity is usually very time-consuming. This paper develops the Kron's substructuring method to compute the first-order derivatives of the eigenvalues and eigenvectors with respect to the structural parameters. The global structure is divided into several substructures. The eigensensitivity of the substructures are calculated via the conventional manner, and then assembled into the eigensensitivity of the global structure by performing some constraints on the derivative matrices of the substructures. With the proposed substructuring method, the eigenvalue and eigenvector derivatives with respect to an elemental parameter are computed within the substructure solely which contains the element, while the derivative matrices of all other substructures with respect to the parameter are zero. Consequently this can reduce the computation cost significantly. The proposed substructuring method is applied to the GARTEUR AG-11 frame and a highway bridge, which is proved to be computationally efficient and accurate for calculation of the eigensensitivity. The influence of the master modes and the division formations are also discussed.

Effects of PTTG Down-regulation on Proliferation and Metastasis of the SCL-1 Cutaneous Squamous Cell Carcinoma Cell Line

Xia, Yong-Hua,Li, Min,Fu, Dan-Dan,Xu, Su-Ling,Li, Zhan-Guo,Liu, Dong,Tian, Zhong-Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Aims: To study effects of down-regulation of pituitary tumor-transforming gene (PTTG) on proliferation and metastasis ability of the SCL-1 cutaneous squamous cell carcinoma (CSCC) cell line and explore related mechanisms. Methods: SCL-1 cells were divided into 3 groups (untreated, siRNA control and PTTG siRNA). Cell proliferation assays were performed using a CCK-8 kit and proliferation and metastasis ability were analyzed using Boyden chambers. In addition, expression of MMP-2 and MMP-9 was detected by r-time qPCR and Western blotting. Results: Down-regulation of PTTG could markedly inhibit cell proliferation in SCL-1 cells, compared to untreated and control siRNA groups (P < 0.05). Real-time qPCR demonstrated that expression levels of PTTG, MMP-2 and MMP-9 in the PTTG siRNA group were 0.8%, 23.2% and 21.3% of untreated levels. Western blotting revealed that expression of PTTG, MMP-2 and MMP-9 proteins in the PTTG siRNA group was obviously down-regulated. The numbers of migrating cells ($51.38{\pm}4.71$) in the PTTG siRNA group was obviously lower than that in untreated group ($131.33{\pm}6.12$) and the control siRNA group ($127.72{\pm}5.20$) (P < 0.05), suggesting that decrease of proliferation and metastasis ability mediated by PTTG knock-down may be closely correlated with down-regulation of MMP-2 and MMP-9 expression. Conclusion: Inhibition of PTTG expression may be a new target for therapy of CSCC.

Calculation of eigenvalue and eigenvector derivatives with the improved Kron’s substructuring method

Yong Xia,Shun Weng,You-Lin Xu,Hong-Ping Zhu 국제구조공학회 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.36 No.1

For large-scale structures, the calculation of the eigensolution and the eigensensitivity is usually very time-consuming. This paper develops the Kron’s substructuring method to compute the firstorder derivatives of the eigenvalues and eigenvectors with respect to the structural parameters. The global structure is divided into several substructures. The eigensensitivity of the substructures are calculated via the conventional manner, and then assembled into the eigensensitivity of the global structure by performing some constraints on the derivative matrices of the substructures. With the proposed substructuring method, the eigenvalue and eigenvector derivatives with respect to an elemental parameter are computed within the substructure solely which contains the element, while the derivative matrices of all other substructures with respect to the parameter are zero. Consequently this can reduce the computation cost significantly. The proposed substructuring method is applied to the GARTEUR AG-11 frame and a highway bridge, which is proved to be computationally efficient and accurate for calculation of the eigensensitivity. The influence of the master modes and the division formations are also discussed.

Chrysin inhibits cell invasion by inhibition of Recepteur d’origine Nantais via suppressing early growth response-1 and NF-κB transcription factor activities in gastric cancer cells

XIA, YONG,LIAN, SEN,KHOI, PHAM NGOC,YOON, HYUN JOONG,HAN, JAE YOUNG,CHAY, KEE OH,KIM, KYUNG KEUN,JUNG, YOUNG DO Spandidos Publications 2015 International journal of oncology Vol.46 No.4

<P>Cell invasion is one of crucial reasons for cancer metastasis and malignancy. Recepteur d'origine Nantais (RON) has been reported to play an important role in the cancer cell invasion process. High accumulation and activation of RON has been implicated in gastric adenocarcinoma AGS cells. Chrysin is a naturally occurring phytochemical, a type of flavonoid, which has been reported to suppress tumor metastasis. However, the effects of chrysin on RON expression in gastric cancer are not well studied. In the present study, we examined whether chrysin affects RON expression in gastric cancer, and if so, its underlying mechanism. We examined the effect of chrysin on RON expression and activity, via RT-PCR, promoter study, and western blotting in human gastric cancer AGS cells. Chrysin significantly inhibited endogenous and inducible RON expression in a dose-dependent manner. After demonstrating that Egr-1 and NF-kappa B are the critically required transcription factors for RON expression, we discovered that chrysin suppressed Egr-1 and NF-K13 transcription factor activities. Additionally, the phorbol-12-myristate-13-acetate(PMA) induced cell invasion was partially abrogated by chrysin and an RON antibody. Our results suggest that chrysin has anticancer effects at least by suppressing RON expression through blocking Egr-1 and NF-kappa B in gastric cancer AGS cells.</P>

Assembly tightness detection of bolt connections using gray-level images with high-order cumulants

Yong Xia,Xiaoli Zhang,Qiang Yan,Yong Xiao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.10

Bolt connections are widely used in aero-engine rotors and gas turbines because of their load-transferring and detachable characteristics. However, bolts are prone to looseness due to the influence of fatigue, shock, and thermal loads, which decreases the reliability of the bolted connection structure. Therefore, detecting the assembly tightness of bolted connections is critical to ensure structural integrity during the assembly phase. A high-order cumulant-gray-level image feature (HOC-GLI) method is proposed to detect the assembly tightness of bolt connections. The core of this new method is to obtain high-order cumulant images of vibration signals to eliminate noise and reserve rich nonlinear information. The amplitude distribution of the third-order cumulant reflects the energy distribution of the vibration signal in 3D images. Then, the third-order cumulant 3D images are converted to 2D gray-level images to extract the texture feature. Finally, the root entropy index of the normalized gray-level cooccurrence matrix (GLCM) based on gray-level images is used to indicate the complexity of image information. Experimental studies on six bolt connection states of the aero-engine rotor are conducted. The relationship between the root entropy index and bolted connection status is obtained to verify the effectiveness of the proposed method for assembly tightness detection in different bolt connection statuses. The result shows that the root entropy index has a decreasing trend with the loosening of the bolts, which can quantitatively detect the assembly tightness of the bolt connection structure.

Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells

Xia, Yong,Yuan, Miaomiao,Li, Shinan,Thuan, Ung Trong,Nguyen, Thi Thinh,Kang, Taek Won,Liao, Wenzhen,Lian, Sen,Do Jung, Young ACS AMERICAN CHEMICAL SOCIETY 2018 Journal of agricultural and food chemistry Vol.66 No.29