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Developing the Framework of Tacit Knowledge Externalization in International Construction Projects
Qianwen Zhou,Xiaopeng Deng,Bon-Gang Hwang,Xianbo Zhao,Na Zhang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.9
Although tacit knowledge management has gained increasing attention in international construction projects, little effort has been devoted to the externalization of tacit knowledge for project managers and members. This research aims to explore various factors that affect the process of tacit knowledge externalization (TKE) in international construction projects and analyze the influencing mechanism and degree of these factors on the externalization effect. Based on the comprehensive literature review and in-depth investigations, a theoretical model and ten hypotheses were established. Then, data collected from 302 respondents were used to test the model and hypotheses. The results indicated that the differences among project members (i.e., culture distance and knowledge distance) reduce members’ willingness to convert tacit knowledge, which negatively impacts the externalization effect. Furthermore, organizational management (i.e., organizational climate and incentive mechanism) plays an active role in increasing members’ externalization willingness. Incentive mechanism and information technology are beneficial to increasing the coding level of knowledge, which positively impacts the externalization effect. Moreover, a strong willingness to convert tacit knowledge helps enhance the coding level of knowledge, thereby improving the effect of TKE. This study advances previous research by developing a framework for TKE in international construction projects, thereby offering recommendations for project managers and members to promote the externalization process.
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miR-122 promotes diabetic retinopathy through targeting TIMP3
Wang Mingliang,Zheng Huifen,Zhou Xianbo,Zhang Jiwei,Shao Guanghui 한국통합생물학회 2020 Animal cells and systems Vol.24 No.5
Diabetic retinopathy (DR) is a primary complication of diabetes mellitus. DR can cause severe vision loss for patients. miR-122 is elevated in DR patients, while its role in DR is unclear. Hence, the purpose of this study was to analyze the effect of miR-122 on the function of high glucoseinduced REC cells and the underlying molecular mechanisms. In this study, our results revealed that miR-122 was up-regulated in high glucose-induced human retinal pigment epithelial cells (ARPE-19). High glucose decreased the cell viability of ARPE-19 cells, which was then restored by miR-122 knockdown. In addition, miR-122 knockdown suppressed apoptosis of high glucoseinduced ARPE-19 cells. High glucose also inhibited B-cell lymphoma-2 (Bcl-2) level and increased cleaved caspase-3 level in ARPE-19 cells, which were reversed by miR-122 knockdown. Tissue inhibitor of metalloproteinases-3 (TIMP3) was a direct target of miR-122. TIMP3 was decreased in high glucose-induced ARPE-19 cells, and the decrease was abrogated by miR-122 knockdown. In addition, the effects of miR-122 overexpression in cell viability and apoptosis of high glucoseinduced ARPE-19 were abolished by overexpression of TIMP3. In conclusion, the effect and mechanism of miR-122 on high glucose-induced ARPE-19 cells were demonstrated for the first time. miR-122 promoted diabetic retinopathy through targeting TIMP3, making miR-122 a promising target for diabetic retinopathy therapy.
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