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Catalytic Combustion of Propionaldehyde over Alumina-Supported Manganese Oxides
Yi Liu,Zhong-Kun Ma,Seong-Gyu Seo 한국냄새환경학회 2011 실내환경 및 냄새 학회지 Vol.10 No.1
In this study, the catalytic combustion of propionaldehyde, which is an Offensive Odorant Substance assigned by the Korean Ministry of Environment (KMOE), over alumina-supported manganese oxide (Mn/Al2 O3) catalysts was investigated. The combustion reaction was carried out in a fixed-bed reactor at the temperature range of 200 ∼340 ℃. Mn/Al2O3 catalysts with Mn loadings ranging from 3.9 to 18.3 wt.% were prepared by impregnation method. The physicochemical characteristics of the catalysts were analyzed by X-Ray Diffraction (XRD), Scanning Electronic Microscopy (SEM) and Brunauer-Emmett-Teller (BET). The Mn crystalline phases of the Mn/Al2O3 catalysts were identified as α-Mn2O3 and β-MnO2. Mn oxides were covered on γ-Al2O3 supports with an average diameter of around 1 μm. With the increase of Mn loadings, the BET surface areas, pore volumes and average pore diameters of the Mn/Al2O3 catalysts decreased. The catalytic activities of Mn/Al2O3 catalysts increased as the Mn loading was increased from 3.9 wt.% to 18.3 wt.%. The catalyst with 18.3 wt.% Mn loading was able to achieve 100% propionaldehyde conversion at 260 ℃. For the same temperature, a lower Gas Hourly Space Velocity (GHSV) and a lower propionaldehyde concentration promote the complete combustion of propionaldehyde.
Characteristics of Odor in the Major Facilities of a Fishery Industrial Complex
Seong-Gyu Seo,Zhong-Kun Ma,Jun-Min Jeon 한국냄새환경학회 2009 실내환경 및 냄새 학회지 Vol.8 No.2
The objectives of this study were to analyze the characteristics of odor in the major facilities of a fishery industrial complex using the air dilution olfactory method and the instrumental analysis method. The results indicate that although the limit of dilution to threshold (D/T) ratio in the major facilities is not regulated by the Odor Emission Standard, the mean (D/T) ratio over than 3,000 which is higher than the limit in the outlet of industrial area 3 times was found at three sampling sites. In the case of the concentration of the malodorous compounds, ammonia concentration is higher than any other odor compounds. The methyl mercaptan, n-Butyric acid and hydrogen sulfide as the main pollutants are confirmed by the odor quotient (OQ). In our study, it is showed a moderately good correlation between the (D/T) ratio and the sum of OQ. By this result, we can estimate the odor characteristics and evaluate the potential impact of each odor compound. In addition, we consider that it will affect the people"s normal life and even cause for complaint around the boundary area by the diffusion of odor.
Li, Xing,Zhong, Xiang,Chen, Zhan-Hong,Wang, Tian-Tian,Ma, Xiao-Kun,Xing, Yan-Fang,Wu, Dong-Hao,Dong, Min,Chen, Jie,Ruan, Dan-Yun,Lin, Ze-Xiao,Wen, Jing-Yun,Wei, Li,Wu, Xiang-Yuan,Lin, Qu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background and Aims: Hepatitis B virus (HBV) reactivation was reported to be induced by transcatheter arterial chemoembolization (TACE) in HBV-related hepatocellular carcinonma (HCC) patients with a high incidence. The effective strategy to reduce hepatitis flares due to HBV reactivation in this specific group of patients was limited to lamivudine. This retrospective study was aimed to investigate the efficacy of prophylactic entecavir in HCC patients receiving TACE. Methods: A consecutive series of 191 HBV-related HCC patients receiving TACE were analyzed including 44 patients received prophylactic entecavir. Virologic events, defined as an increase in serum HBV DNA level to more than 1 log10 copies/ml higher than nadir the level, and hepatitis flares due to HBV reactivation were the main endpoints. Results: Patients with or without prophylactic were similar in host factors and the majorities of characteristics regarding to tumor factors, HBV status, liver function and LMR. Notably, cycles of TACE were parallel between the groups. Ten (22.7%) patients receiving prophylactic entecavir reached virologic response. The patients receiving prophylactic entecavir presented significantly reduced virologic events (6.8% vs 54.4%, p=0.000) and hepatitis flares due to HBV reactivation (0.0% vs 11.6%, p=0.039) compared with patients without prophylaxis. Kaplan-Meier analysis illustrated that the patients in the entecavir group presented significantly improved virologic events free survival (p=0.000) and hepatitis flare free survival (p=0.017). Female and Eastern Cooperative Oncology Group (ECOG) performance status 2 was the only significant predictors for virological events in patients without prophylactic antiviral. Rescue antiviral therapy did not reduce the incidence of hepatitis flares due to HBV reactivation. Conclusion: Prophylactic entecavir presented promising efficacy in HBV-related cancer patients receiving TACE. Lower performance status and female gender might be the predictors for HBV reactivation in these patients.
Li, Xing,Zhong, Xiang,Chen, Zhan-Hong,Xing, Yan-Fang,Wu, Dong-Hao,Chen, Jie,Ma, Xiao-Kun,Lin, Qu,Wen, Jing-Yun,Wei, Li,Wang, Tian-Tian,Ruan, Dan-Yun,Lin, Ze-Xiao,Wu, Xiang-Yuan,Dong, Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22
Background: This retrospective study was aimed to investigate the efficacy of prophylactic agents in hepatocellular carcinoma (HCC) patients receiving TACE and compare the difference between lamivudine and entecavir. Materials and Methods: A consecutive series of 203 HBV-related HCC patients receiving TACE were analyzed including 91 patients given prophylactic agents. Virologic events, defined as an increase in serum HBV DNA level to more than 1 log10 IU/ml higher than the nadir level, hepatitis flares due to HBV reactivation and progression free survival (PFS) were the main endpoints. Results: Some 48 (69.6%) reached virologic response. Prophylaxis significantly reduced virologic events (8.8% vs 58.0%, p=0.000) and hepatitis flares (1.1% vs 13.4%, p=0.001). Patients presenting undetectable HBV DNA levels displayed a significantly improved PFS as compared to those who never achieved undetectable HBV DNA. Prophylaxis and e-antigen positivity were the only significant variables associated with virologic events. In addition, prophylaxis was the only independent protective factor for hepatitis flares. Liver cirrhosis, more cycles of TACE, HBV DNA negativity, a lower Cancer of the Liver Italian Program score, non-metastasis and no hepatitis flares were protective factors for PFS. Prophylactic lamivudine demonstrated similar efficacy as entecavir. Conclusions: Prophylactic agents are efficacious for prevention of HBV reactivation in HCC patients receiving TACE. Achievement of undetectable HBV DNA levels displayed a significant capability in improving PFS. Moreover, persistent tumor residual lesions, positive HBV DNA and hepatitis B flares might be causes of tumor progression in these patients.
p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid
Liu, Jia,Wu, Ning,Ma, Lei-Na,Zhong, Jia-Teng,Liu, Ge,Zheng, Lan-Hong,Lin, Xiu-Kun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Oleanolic acid (OA) is a nutritional component widely distributed in various vegetables. Although it has been well recognized for decades that OA exerts certain anti-tumor activity by inducing mitochondria-dependent apoptosis, it is still unclear that what molecular signaling is responsible for this effect. In this study, we employed cancer cell lines, A549, BXPC-3, PANC-1 and U2OS to elucidate the molecular mechanisms underlying OA anti-tumor activity. We found that activation of MAPK pathways, including p-38 MAPK, JNK and ERK, was triggered by OA in both a dose and time-dependent fashion in all the tested cancer cells. Activation was accompanied by cleavage of caspases and PARP as well as cytochrome C release. SB203580 (p38 MAPK inhibitor), but not SP600125 (JNK inhibitor) and U0126 (ERK inhibitor), rescued the pro-apoptotic effect of OA on A549 and BXPC-3 cells. OA induced p38 MAPK activation promoted mitochondrial translocation of Bax and Bim, and inhibited Bcl-2 function by enhancing their phosphorylation. OA can induce reactive oxygen species (ROS)-dependent ASK1 activation, and this event was indispensable for p38 MAPK-dependent apoptosis in cancer cells. In vivo, p38 MAPK knockdown A549 tumors proved resistant to the growth-inhibitory effect of OA. Collectively, we elucidated that activation of ROS/ASK1/p38 MAPK pathways is responsible for the apoptosis stimulated by OA in cancer cells. Our finding can contribute to a better understanding of molecular mechanisms underlying the antitumor activity of nutritional components.
서성규(Seong Gyu Seo),마충곤(Zhong Kun Ma),류의(Yi Liu),윤형선(Hyung Sun Yoon),김상채(Sang Chai Kim) 大韓環境工學會 2011 대한환경공학회지 Vol.33 No.4
본 연구에서는 Mn-PC 촉매와 상압유통식 반응장치를 이용하여 200~380℃ 범위에서 VOCs(아세트알데히드, 프로피온알데히드, 톨루엔) 연소반응을 수행하였다. 촉매 전처리(air, 450℃, 1 hr, 60 cc/min) 전·후의 물리화학적 특성변화 조사는 TGA (Thermogravimetric Analyzer), BET (Brunauer Emmett Teller), EA (Elemental Analyzer), XRD (X-ray Diffractometer) 및 SEM (Scanning Electronic Microscope)을 이용하여 파악하였다. TGA 분석결과 Mn-PC의 열중량(공기 분위기) 감소는 419℃에서 88 wt.%를 나타내었으며, 전처리 후 비표면적은 크게 증가하는 것으로 확인되었다. EA 분석결과 전처리를 통해서 유기물 성분은 분해 또는 연소되어 거의 관찰되지 않는 것으로 파악되었다. 또한 XRD분석을 통해 Mn-PC 촉매가 전처리 후 새로운 형태의 산화물인 Mn3O₄로 전이됨을 확인하였다. 그리고 SEM 분석결과 전처리 과정에서 많은 micropore가 생성된 것으로 관찰되었다. 프로피온알데히드 연소의 경우 전처리한 Mn-PC는 Mn3O₄와 fresh한 Mn-PC 보다 우수한 촉매활성을 나타내었다. 전처리된 Mn-PC상에서 VOCs 연소 효과는 톨루엔 < 아세트알데히드 < 프로피온알데히드 순서로 나타났다. In this study, the catalytic activity of Mn-Phthalocyanine (Mn-PC) for VOCs (acetadehyde, propionaldehyde and toluene) combustion was determined. The reaction was carried out in a fixed bed reactor at the temperature range of 200~380℃. We investigated the physicochemical properties of Mn-PC before and after the pretreatment (air, 450℃, 1 hr, 60 cc/min) by TGA (Thermogravimetric Analyzer), BET (Brunauer Emmett Teller), EA (Elemental Analyzer), XRD (X-ray Diffractometer) and SEM (Scanning Electronic Microscope). By TGA analysis, 88 wt.% mass loss of Mn-PC was found at 419℃. The BET surface area of Mn-PC increased after the pretreatment. The decomposition and combustion of organic components in Mn-PC were observed by EA analysis. We also confirmed that Mn-PC had transformed into a new manganese oxide phase (Mn3O₄) after the pretreatment by XRD analysis. By SEM analysis, many of the micropores generated during the pretreatment were found. The catalytic activity of Mn-PC with the pretreatment for propionaldehyde combustion was higher than that of Mn3O₄ and fresh Mn-PC. It showed the catalytic activity of Mn-PC with the pretreatment for VOCs combustion by the order of toluene < acetadehyde < propionaldehyde.