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RISS 인기검색어
- 검색키워드
- 저자 : Zhiyong Huan (검색결과 3 건)
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Yang, Yuting,Gao, Huan,Li, Xing,Cao, Zhenhui,Li, Meiquan,Liu, Jianping,Qiao, Yingying,Ma, Li,Zhao, Zhiyong,Pan, Hongbin Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.1
Objective: Temperature could influence protein and amino acid deposition as well as gut microbiota profile and composition. However, the specific effects of ambient temperature on amino acids deposition and gut microbiota composition remain insufficiently understood. Methods: A total of 300 one-day-old Avian broilers were randomly divided into three groups and reared at high, medium, and low temperature (HT, MT, and LT), respectively. Breast muscle and fecal samples were collected for amino acid composition analysis and 16S rRNA gene sequence analysis. Results: Our data showed that compared to the MT group, there was a decrease of muscle leucine and tyrosine (p<0.05), as well as an increase of methionine in the HT group (p<0.05) and a decrease of serine in the LT group. Examination of microbiota shift revealed that at genus level, the relative abundance of Turicibacter and Parabacteroides was increased in the HT group (p<0.05) and that the relative abundances of Pandoraea, Achromobacter, Prevotella, Brevundimonas, and Stenotrophomonas in the LT group were higher than those in the MT group (p<0.05). In addition, there were substantial correlations between microbes and amino acids. In the HT group. Turicibacter was negatively correlated with aspartic acid and tyrosine, whereas Parabacteroides was positively correlated with methionine (p<0.05). In the LT group, there were multiple positive correlations between Achromobacter and arginine, isoleucine or tyrosine; between Prevotella and cysteine or phenylalanine; between Brevundimonas and cysteine; and between Stenotrophomonas and cysteine as well as a negative correlation between Stenotrophomonas and serine. Conclusion: Our findings demonstrated that amino acid content of breast muscle and intestinal microbiota profile was affected by different ambient temperatures. Under heat exposure, augmented abundance of Parabacteroides was correlated with elevated methionine. Low temperature treatment may affect muscle tyrosine content through the regulation of Achromobacter.
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Yang Yanhong,Chen Zhiyong,Le Huan 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.1
Background It is reported that LncRNAs play an important role in various diseases, including myocardial ischemia–reperfusion injury. However, the regulatory mechanism of LncRNAs in I/R injury of cardiac has not been fully elucidated. Objective This study aimed to explore the interaction of LncRNA MALAT1 and aberrant histone modification in I/R injury cardiomyocytes. Results After myocardial I/R or H/R injury, the expression level of CTCF was up-regulated and MALAT1 was downregulated. Silencing of CTCF promoted the cardiomyocytes survival and apoptosis after H/R treatment. Moreover, the expression of H3K27me3 was significantly inhibited by CTCF down-regulation. H3K27me3 protein could directly bind to the promoter of MALAT1. In addition, we found that the inhibition CTCF could up-regulate the expression of MALAT1 in cardiomyocytes. In addition, down-regulation of MALAT1 could reverse the effects of silencing of CTCF on cardiomyocytes growth and apoptosis in H/R injury. Furthermore, the bioinformatic analysis showed 12 potential targets, while only miR- 26b-5p could directly bind with MALAT1. The inhibition of CTCF repressed the miR-26b-5p expression and the silencing of MALAT1 promoted miR-26b-5p expression. Besides, the miR-26b-5p was decreased in cardiomyocytes under H/R treatment. Overexpression of MALAT1 significantly promoted cardiomyocytes cell growth and repressed cell apoptosis, while the miR-26b-5p reversed these effects. In myocardial I/R injury mice model, overexpression of MALAT1 alleviated the myocardial tissue injury and repressed the H3K27me3 level, however, all those effects were reversed by CTCF. Conclusions CTCF was highly expressed in H/R cardiomyocytes and I/R myocardial tissue and the silencing of CTCFmediated H3K27me3 dissociating from the MALAT1 promoter to regulate cardiomyocytes survival and apoptosis by targeting miR-26b-5p. It provided a new therapeutic marker for myocardial I/R injury.
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Audio-Visual Attention Control of a Pan-Tilt Telepresence Robot
Keng Peng Tee,Rui Yan,Yuanwei Chua,Zhiyong Huan 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
This paper presents an audio-visual attention control system to establish focus of attention for a pan-tilt telepresence robot. Our system is able to detect attentions automatically and reliably in a telepresence scenario using audio-visual stimuli based on speech and face detection. We also describe an audio-visual attention fusion method with context-dependent prioritization among competing modules of face tracking and sound localization. In comparison to the current telepresence system, our system involves automatic tracking of users’ movement and the user need not manually control the robot. We further implemented this attention control system on a pan-tilt robot, and performed an experimental study that illustrates tracking performance when interacting in real time with human users.
ScienceON
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