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- 저자 : Zhi-Xiang Xun (검색결과 3 건)
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Li Zhi-yu,Liu Ying,Han Zhuo-na,Li Xiang,Wang Yue-ying,Cui Xun,Zhang Ying 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6
WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. Therefore, the purpose of this study was to investigate the effect of Wnt agonist 1 (Wnta1) on ANP secretion and mechanical dynamics in beating rat atria. Wnta1 treatment significantly increased atrial ANP secretion and pulse pressure; these effects were blocked by U73122, an antagonist of phospholipase C. U73122 also abolished the effects of Wnta1-mediated upregulation of protein kinase C (PKC) β and γ expression, and the PKC antagonist Go 6983 eliminated Wnta1-induced secretion of ANP. In addition, Wnta1 upregulated levels of phospho-transforming growth factor-β activated kinase 1 (p-TAK1), TAK1 banding 1 (TAB1) and phospho-activating transcription factor 2 (p-ATF2); these effects were blocked by both U73122 and Go 6983. Wnta1-induced ATF2 was abrogated by inhibition of TAK1. Furthermore, Wnta1 upregulated the expression of T cell factor (TCF) 3, TCF4, and lymphoid enhancer factor 1 (LEF1), and these effects were blocked by U73122 and Go 6983. Tak1 inhibition abolished the Wnta1-induced expression of TCF3, TCF4, and LEF1 and Wnta1-mediated ANP secretion and changes in mechanical dynamics. These results suggest that Wnta1 increased the secretion of ANP and mechanical dynamics in beating rat atria by activation of PKC–TAK1–ATF2–TCF3/LEF1 and TCF4/LEF1 signaling mainly via the WNT/Ca2+ pathway. It is also suggested that WNT–ANP signaling is implicated in cardiac physiology and pathophysiology.
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Variability analysis on modal parameters of Runyang Bridge during Typhoon Masta
Jian-Xiao Mao,Hao Wang,Zhi-Xiang Xun,Zhong-Qin Zou 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.6
The modal parameters of the deck of Runyang Suspension Bridge (RSB) as well as their relationships with wind and temperature are studied based on the data recorded by its Structural Health Monitoring System (SHMS). Firstly, frequency analysis on the vertical responses at the two sides of the deck is carried out to distinguish the vertical and torsional vibration modes. Then, the vertical, torsional and lateral modal parameters of the deck of RSB are identified using Hilbert-Huang Transform (HHT) and validated by the identified results before RSB was opened to traffic. On the basis of this, the modal frequencies and damping ratios of RSB during the whole process of Typhoon Masta are obtained. And the correlation analysis on the modal parameters and wind environmental factors is then conducted. Results show that the HHT can achieve an accurate modal identification of RSB and the damping ratios show an obvious decay trend as the frequencies increase. Besides, compared to frequencies, the damping ratios are more sensitive to the environmental factors, in particular, the wind speed. Further study on configuring the variation law of modal parameters related with environmental factors should be continued.
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Chenyang Xia,Cong Zhu,Yu-Xiang Peng,Zhi-Xun Ma 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.2
In order to reduce harmonic component of inductively coupled power transfer (ICPT) system, this work proposes a twochannel ICPT system based on the harmonic of inverse injection which detects the harmonic component of fundamental wave channel by controlling the harmonic of inverse injection from harmonic channel. First, based on the transfer admittance model, each harmonic component in the fundamental wave channel is analyzed to determine the size and ordinal number of harmonic which needs to be eliminated. Then, the principle block diagram of the system is given. Accordingly, the harmonic channel should possess good constant current and frequency-selecting property. The resonance compensation topology of the harmonic channel is determined by making the comparative analysis of frequency-selecting property of LCCL and LCL. Finally, conditions of the selected harmonic elimination can be derived by optimizing the whole system parameter. Experiment shows that when parameter optimization is achieved, the novel ICPT system can off set the selected harmonic of output current of high-frequency inverter in the fundamental wave channel, achieving high-quality electric power transmission.
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