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Li, Changtian,Yan, Zhengfei,Zhang, Lianxue,Li, Yu The Korean Society of Ginseng 2014 Journal of Ginseng Research Vol.38 No.4
Jilin Province is one of the principal production bases of traditional Chinese medicine (TCM) in China with its typical preponderance in TCM resources, research and development power, and industrialization capacity. The province has 2,790 species of TCM materials in total. Over 20% of the TCM materials in common use are from Jilin Province. The province has established 36 good agricultural practice bases for 22 typical TCMs. The overall situation, in terms of collection, processing, and preparation, and the implementation of good agricultural practice of TCM materials in Jilin Province are summarized.
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Changtian Li,Zhengfei Yan,Lianxue Zhang,Yu Li 고려인삼학회 2014 Journal of Ginseng Research Vol.38 No.4
Jilin Province is one of the principal production bases of traditional Chinese medicine (TCM) in Chinawith its typical preponderance in TCM resources, research and development power, and industrializationcapacity. The province has 2,790 species of TCM materials in total. Over 20% of the TCM materials incommon use are from Jilin Province. The province has established 36 good agricultural practice bases for22 typical TCMs. The overall situation, in terms of collection, processing, and preparation, and theimplementation of good agricultural practice of TCM materials in Jilin Province are summarized.
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Gao, Wei,Lin, Pei,Hwang, Eunson,Wang, Yushuai,Yan, Zhengfei,Ngo, Hien T.T.,Yi, Tae-Hoo Pergamon Press 2018 Photochemistry and photobiology Vol.94 No.1
<P>Ultraviolet light-induced reactive oxygen species (ROS) damage human skin and prematurely cause aging. A growing body of research is focusing on considering plants and plant-derived compounds as antiphotoaging therapeutic material. Pterocarpus santalinus L., as an Indian traditional medicine, possesses antidiabetic, anti-inflammatory and antioxidative effects. Here, we studied the antiphotoaging effects of ethanolic extract of P. santalinus L. heartwood (EPS) on ultraviolet radiation B (UVB)-irradiated normal human dermal fibroblasts (NHDFs). Results showed that EPS significantly inhibited the upregulation of matrix metalloproteinases and IL-6 caused by UVB irradiation, and suppressed UVB-induced phosphorylation of extracellular signal-regulated kinase, Jun N-terminal kinase and p38, as well as the activation of AP-1 transcription factors. Further study indicated that UVB-induced production of MMP-1 and IL-6 could be inhibited by PD 98059 (an ERK inhibitor) and SP600125 (A JNK inhibitor), implied that EPS inhibited UVB-induced MMP-1 and IL-6 secretion by inactivating MAPK signaling pathway. In addition, EPS possessed an excellent antioxidant activity, which could increase cytoprotective antioxidants such as HO-1, NQ-O1 expression by facilitating the nuclear accumulation of Nrf2. Treatment of NHDFs with EPS also recovered UVB-induced procollagen type I reduction by activating TGF-beta/Smad pathway. These findings demonstrated that EPS had a potential effect against UVB-induced skin photoaging.</P>
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Gao, Wei,Wang, Yu-shuai,Hwang, Eunson,Lin, Pei,Bae, Jahyun,Seo, Seul A.,Yan, Zhengfei,Yi, Tae-Hoo Elsevier 2018 Journal of photochemistry and photobiology Biology Vol.185 No.-
<P><B>Abstract</B></P> <P>Chronic exposure to ultraviolet (UV) radiation causes photo-oxidation, which in turn results in the upregulation of matrix metalloproteinases (MMPs) and loss of collagen. <I>Rubus idaeus</I> L. (RI), also called red raspberry, is an important cash crop that contains abundant antioxidant compounds. Sanguiin H-6 and lambertianin C are the major ingredients presented in the extracts. Here, we studied the protective effect of RI on UVB-induced photoaging in normal human dermal fibroblasts (NHDFs). We found that RI notably reduced UVB-induced MMPs secretion and pro-inflammatory mediators production, and significantly suppressed UVB-induced activation of mitogen-activated protein kinase (MAPK), nuclear factor-κβ, as well as activator protein 1. Additionally, treatment of NHDFs with the ERK inhibitor (PD98059) and JNK inhibitor (SP600125) resulted in the reduction of UVB-induced MMP-1 and IL-6 expressions, which demonstrated that the inhibition of MMP-1 and IL-6 by RI is associated with the MAPK pathway. Furthermore, we also found that RI accelerated procollagen type I synthesis by activating the transforming growth factor-β/Smad pathway and enhanced the expression of cytoprotective antioxidants such as heme oxygenase-1 and NHD(P)H quinone oxidoreductase 1 by promoting nuclear factor E2-related factor 2 nuclear transfer. Overall, these findings demonstrated that RI was potentially effective in preventing UVB induced skin photoaging.</P> <P><B>Highlights</B></P> <P> <UL> <LI> RI blocks MMPs and IL-6 secretion by inhibition of MAPK/AP-1 signaling pathway. </LI> <LI> RI promotes procollagen type I synthesis by activation of TGF-β/Smad signaling pathway. </LI> <LI> RI enhances cytoprotective antioxidants expression by stimulation of Nrf2 nuclear transfer. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Chronic exposure to UV radiation results in skin premature aging (photoaging), clinically accompanied with loss of elasticity and tension. In this study, we demonstrated that RI could reverse this damage via increasing procollagen synthesis and blocking MMPs, inflammatory factors expression. The studies of molecular mechanism indicated RI could inhibit MMPs expression via inactivating MAPK/AP-1, NF-κβ pathway and accelerate type I procollagen synthesis through activating the TGF-β/Smad pathway. Furthermore, RI reduced UVB-enhanced ROS via promoting Nrf2 nuclear location and enhancing the expression of cytoprotective antioxidants.</P> <P>[DISPLAY OMISSION]</P>
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Zheng, Fei,Zhang, Ming,Ding, Qi,Sethna, Ferzin,Yan, Lily,Moon, Changjong,Yang, Miyoung,Wang, Hongbing Cold Spring Harbor Laboratory Press 2016 Learning & Memory Vol.23 No.8
<P>Mental health and cognitive functions are influenced by both genetic and environmental factors. Although having active lifestyle with physical exercise improves learning and memory, how it interacts with the specific key molecular regulators of synaptic plasticity is largely unknown. Here, we examined the effects of voluntary running on long-term potentiation (LTP) and memory formation in mice lacking type 1 adenylyl cyclase (AC1), a neurospecific synaptic enzyme that contributes to Ca2+-stimulated cAMP production. Following 1 mo of voluntary running-wheel exercise, the impaired LTP and object recognition memory in AC1 knockout (KO) mice were significantly attenuated. Running up-regulated exon II mRNA level of BDNF (brain-derived neurotrophic factor), though it failed to increase exon I and IV mRNAs in the hippocampus of AC1 KO mice. Intrahippocampal infusion of recombinant BDNF was sufficient to rescue LTP and object recognition memory defects in AC1 KO mice. Therefore, voluntary running and exogenous BDNF application overcome the defective Ca2+-stimulated cAMP signaling. Our results also demonstrate that alteration in Ca2+-stimulated cAMP can affect the molecular outcome of physical exercise.</P>
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