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- 저자 : Zhen-di Hu (검색결과 3 건)
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Yecheng Wang,Zhen Luo,Di Zhang,Yue Yang,Jianming Hu,Muse Degefe Chewaka,Sansan Ao,Yang Li 한국탄소학회 2023 Carbon Letters Vol.33 No.1
Carbon nanotube fiber is a promising material in electrical and electronic applications, such as, wires, cables, batteries, and supercapacitors. But the problem of joining carbon nanotube fiber is a main obstacle for its practical development. Since the traditional joining methods are unsuitable because of low efficiency or damage to the fiber structure, new methods are urgently required. In this study, the joining between carbon nanotube fiber was realized by deposited nickel–copper doublelayer metal via a meniscus-confined localized electrochemical deposition process. The microstructures of the double-layer metal joints under different deposition voltages were observed and studied. It turned out that a complete and defect-free joint could be fabricated under a suitable voltage of 5.25 V. The images of the joint cross section and interface between deposited metal and fiber indicated that the fiber structure remained unaffected by the deposited metal, and the introduction of nickel improved interface bonding of double-layer metal joint with fiber than copper joint. The electrical and mechanical properties of the joined fibers under different deposition voltages were studied. The results show that the introduction of nickel significantly improved the electrical and mechanical properties of the joined fiber. Under a suitable deposition voltage, the resistance of the joined fiber was 37.7% of the original fiber, and the bearing capacity of the joined fiber was no less than the original fiber. Under optimized condition, the fracture mode of the joined fibers was plastic fiber fracture.
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Fei Yin,Qing Sheng Lin,Xia Feng,Huan-yu Chen,Zhen-yu Li,Zhen-di Hu 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.1
Plutella xylostella (L.), aworldwide vegetable pest, has developed resistance to spinetoram,whichwas previously effective for the control of P. xylostella (L.). The insecticidal resistance mechanismis essential to develop effective resistance management strategies. To explore the spinetoram resistance mechanism, a comparative proteomics approach was used to investigate the proteomic differences between the spinetoram-susceptible strain (SS) and spinetoram-resistant strain (RS) of P. xylostella (L.). Approximately 280 protein spotswere detected on each SDSPAGE gel. Of these, 19 proteinswere successfully identified byMALDI-TOF-MS.·Therewere 6 significantly downregulated spots and 13 up-regulated spots in RS, which showed significantly difference compared to that in SS. Based on the gene ontology(GO) system and KEGG database, the 19 identified proteins were classified into 6 groups includingmetabolisms, signal transduction, chaperones, transcriptional, protein synthesis, structural protein. Meanwhile, the expression profiles of 5 resistant related protein were further analysed by qRT-PCR. The results showed that 60S acidic ribosomal protein P2, glutathione S-transferase isozyme 3 and glutathione Stransferase deltawere significantly up-regulated,while phosphoglyceratemutase and receptor for activated protein kinase C homolog were significantly down-regulated. The expression tendency of mRNA was in accordance with which of protein. This study provided evidences that spinetoram induces proteomic changes in P. xylostella (L.), and it is contributed to help us understand the resistance mechanism of P. xylostella (L.) to spinetoram.
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Chen, Peng,Wang, Xiu-Li,Ma, Zhong-Sen,Xu, Zhong,Jia, Bo,Ren, Jin,Hu, Yu-Xin,Zhang, Qing-Hua,Ma, Tian-Gang,Yan, Bing-Di,Yan, Qing-Zhu,Li, Yan-Lei,Li, Zhen,Yu, Jin-Yan,Gao, Rong,Fan, Na,Li, Bo,Yang, Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7
HMGN5 is a typical member of the HMGN (high mobility group nucleosome-binding protein) family which may function as a nucleosomal binding and transcriptional activating protein. Overexpression of HMGN5 has been observed in several human tumors but its role in tumorigenesis has not been fully clarified. To investigate its significance for human lung cancer progression, we successfully constructed a shRNA expression lentiviral vector in which sense and antisense sequences targeting the human HMGN5 were linked with a 9-nucleotide loop. Inhibitory effects of siRNA on endogenous HMGN5 gene expression and protein synthesis were demonstrated via real-time RT-PCR and western blotting. We found HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation assessed by MTT, BrdU incorporation and colony formation assays. Furthermore, flow cytometry analysis showed that specific knockdown of HMGN5 slowed down the cell cycle at the G0/G1 phase and decreased the populations of A549 and H1299 cells at the S and G2/M phases. Taken together, these results suggest that HMGN5 is directly involved in regulation cell proliferation in A549 and H1299 cells by influencing signaling pathways involved in cell cycle progression. Thus, our finding suggests that targeting HMGN5 may be an effective strategy for human lung cancer treatment.
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