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Method for Network Traffic Generation Based on User Behavior of Streaming Media
Shuai Zeng,Zhongying Wang,Guofeng Zhao,Shaocong Gai,Jie Duan,Yi Zhang 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.12
Existing traffic generation methods generate traffic by the flow generator structured and then sent data packets, which had two problems, one is that the traffic generated is not enough authenticity, the other one is that the rate of flow is not high. For coping with the method for network traffic generation based on user behavior of streaming media and streaming media server was presented. The test results show that comparing with D-ITG, the size of traffic produced by this method has been obviously improved, and its principle indicates that the flow is highly authentic. The proposed method breaks through the traditional thinking of traffic generator sends packet by itself, which decreases the difficulty of the realization of the traffic generator and has good reference value for the researches and development of traffic generator.
Zhang, Yi-Bo,Zhao, Wei,Zeng, Rui-Xia Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Oxidative stress induces apoptosis in many cellular systems including glioblastoma cells, with caspase-8 activation was regarded as a major contribution to $H_2O_2$-induced cell death. This study focused on the role of the autophagic protein p62 in $H_2O_2$-induced apoptosis in U87MG cells. Oxidative stress was applied with $H_2O_2$, and cell apoptosis and viability were measured with use of caspase inhibitors or autophagic mediators or siRNA p62, GFP-p62 and GFP-p62-UBA (del) transfection. We found that $H_2O_2$-induced U87MG cell death was correlated with caspase-8. To understand the role of p62 in MG132-induced cell death, the levels of p62/SQSTM1 or autophagy in U87MG cells were modulated with biochemical or genetic methods. The results showed that the over-expression of wild type p62/SQSTM1 significantly reduced $H_2O_2$ induced cell death, but knockdown of p62 aggravated the process. In addition, inhibition of autophagy promoted p62 and active caspase-8 increasing $H_2O_2$-induced apoptosis while induction of autophagy manifested the opposite effect. We further demonstrated that the function of p62/SQSTM1 required its C-terminus UBA domain to attenuate $H_2O_2$ cytotoxity by inhibition of caspase-8 activity. Our results indicated that p62/SQSTM1 was a potential contributor to mediate caspase-8 activation by autophagy in oxidative stress process.
Hou, Wenpeng,Zhao, Ning-Jiu,Meng, Dongli,Tang, Jing,Zeng, Yi,Wu, Yu,Weng, Yangziwan,Cheng, Chungui,Xu, Xiulai,Li, Yi,Zhang, Jian-Ping,Huang, Yong,Bielawski, Christopher W.,Geng, Jianxin American Chemical Society 2016 ACS NANO Vol.10 No.5
<P>The installation of heterojunctions on the surfaces of carbon nanotubes (CNTs) is an effective method for promoting the charge separation processes needed for CNT-based electronics and optoelectronics applications. Conjugated polymers are proven state-of-the-art candidates for modifying the surfaces of CNTs. However, all previous attempts to incorporate conjugated polymers to CNTs resulted in unordered interfaces. Herein we show that well-defined chains of regioregular poly(3-hexylthiophene) (P3HT) were successfully grown from the surfaces of multiwalled CNTs (MWNTs) using surface-initiated Kumada catalyst-transfer polycondensation. The polymerization was found to proceed in a controlled manner as chains of tunable lengths were prepared through variation of the initial monomer-to-initiator ratio. Moreover, it was determined that large-diameter MWNTs afforded highly ordered P3HT aggregates, which exhibited a markedly bathochromically shifted optical absorption due to a high grafting density induced planarization of the polymer chains. Using ultrafast spectroscopy, the heterojunctions formed between the MWNTs and P3HT were shown to effectively overcome the binding energy of excitons, leading to photoinduced electron transfer from P3HT to MWNTs. Finally, when used as prototype devices, the individual MWNT-g-P3HT core-shell structures exhibited excellent photoresponses under a low illumination density.</P>
A Novel Mutant of Human Papillomavirus Type 18 E6E7 Fusion Gene and its Transforming Activity
Zhou, Zhi-Xiang,Zhao, Chen,Li, Qian-Qian,Zeng, Yi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17
Background: Persistent human papillomavirus (HPV) infection, especially with high-risk types such as HPV16 and HPV18, has been identified as the primary cause of cervical cancer. E6 and E7 are the major onco-proteins of high-risk HPVs, which are consistently expressed in HPV infected tissues but absent in normal tissues and represent ideal therapeutic targets for immunotherapy of cervical cancer. Materials and Methods: In this study, the optimized fusion gene HPV18 E6E7 (HPV18 ofE6E7) was constructed according to genetic codon usage for human genes. At the same time, for safety future clinical application, a mutant of HPV18 ofE6E7 fusion gene was generated by site-directed mutagenesis at L52G for the E6 protein and C98G for the E7 protein. Results: HPV18-E6E7 mutant (HPV18 ofmE6E7) constructed in this work not only lost the transformation capability for NIH 3T3 cells and tumorigenicity in BALB/c nude mice, but also maintained very good stability and antigenicity. Conclusion: These results suggest that the mutant should undergo further study for application as a safe antigenspecific therapeutic vaccine for HPV18-associated tumors.
Modular multilevel converter predictive control strategy based on energy balance
Xia, Xiangyang,Xu, Lei,Zhao, Xinxin,Zeng, Xiaoyong,Zhang, Jing,He, Yedan,Yi, Haigan The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.5
In MMC-HVDC (modular multilevel converter-based high-voltage direct current) applications, conventional control methods have defects such as complicated control and difficulty in controlling the internal energy of the converter. To ensure the safe and stable operation of an MMC-HVDC system, the problem of uneven internal energy distribution and increased fluctuations in the modular multilevel converter under asymmetrical network voltage conditions must be addressed. This paper has designed, a novel model predictive control (MPC) for MMC-HVDC applications. Through the proposed strategy, the switching states of all the MMC units can be optimized, which eliminates the circulating currents and achieves a voltage balance of the capacitor by redundant switching states. Moreover, an energy control circuit is established to adjust the DC bus power distribution in the MMC three-phase bridge arm. Thus, the symmetrical ac-side current can be realized, and the MMC internal energy imbalance caused by the transient process of the system can be avoided. Finally, the proposed novel predictive control strategy is tested via a case study. The obtained simulation and experimental results verify the effectiveness of the proposed control strategy.
An intelligent method to design die profile for rubber forming of complex curved flange part
Ling‑Yun Zhang,Shuai Zhou,Tian‑Zhang Zhao,Yi‑Pan Zeng 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.1
Rubber forming is an important forming process for the manufacture of aircraft sheet metal parts. The springback is one of the main defects in rubber forming. Classical springback compensation by displacement adjustment method using finite simulation is not satisfactory. In this research, the algorithms of compensating the arc and flange surface of complex curved flange with correction formula are proposed by experiment. The correction formula was developed based on the CATIA V5 R19 using Component Application Architecture. Compensate profile is presented including surface pick up, line pick up, division, compensation, extending, and trimming. The die profile of part with complex curved flanges in aircraft could be designed rapidly. It was found that the forming pressure has a little effect on the springback. This is within the tolerance limits of the part. The results reveal the method can achieve the industrial part precisely. The method is demonstrated on an aircraft wing rib part.
A Domain-independent Dual-image based Robust Reversible Watermarking
Xuejing Guo,Yixiang Fang,Junxiang Wang,Wenchao Zeng,Yi Zhao,Tianzhu Zhang,Shi Yun-Qing 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.12
Robust reversible watermarking has attracted widespread attention in the field of information hiding in recent years. It should not only have robustness against attacks in transmission but also meet the reversibility of distortion-free transmission. According to our best knowledge, the most recent robust reversible watermarking methods adopt a single image as the carrier, which might lead to low efficiency in terms of carrier utilization. To address the issue, a novel dual-image robust reversible watermarking framework is proposed in this paper to effectively utilize the correlation between both carriers (namely dual images) and thus improve the efficiency of carrier utilization. In the dual-image robust reversible watermarking framework, a two-layer robust watermarking mechanism is designed to further improve the algorithm performances, i.e., embedding capacity and robustness. In addition, an optimization model is built to determine the parameters. Finally, the proposed framework is applied in different domains (namely domain-independent), i.e., Slantlet Transform and Singular Value Decomposition domain, and Zernike moments, respectively to demonstrate its effectiveness and generality. Experimental results demonstrate the superiority of the proposed dual-image robust reversible watermarking framework.
Li, Xin,Wang, Yang,Li, Xing-Wang,Liu, Bao-Cheng,Zhao, Qing-Zhu,Li, Wei-Dong,Chen, Shi-Qing,Huang, Xiao-Ye,Yang, Feng-Ping,Wang, Quan,Wang, Jin-Fen,Xiao, Yan-Zeng,Xu, Yi-Feng,Feng, Guo-Yin,Peng, Zhi-Ha Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.
Weng, Ling-Ling,Xiang, Jian-Feng,Lin, Jin-Bo,Yi, Shang-Hui,Yang, Li-Tao,Li, Yi-Sheng,Zeng, Hao-Tao,Lin, Sheng-Ming,Xin, Dong-Wei,Zhao, Hai-Liang,Qiu, Shu-Qi,Chen, Tao,Zhang, Min-Guang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.