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        Anti-tumor effect of novel amino acid Schiff base nickel (II) complexes on oral squamous cell carcinoma cells (CAL-27) in vitro

        Zhao Peng,Qiu Haiming,Wei Qiang,Li Yang,Gao Lei,Zhao Peiran 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.2

        Background Oral squamous cell carcinoma (OSCC) is a common skin/oral malignant tumor. In recent years, advancements in the fi eld of medical technology resulted in signifi cant improvement in the treatment and management of OSCC. However, adverse reactions associated with the application of radiotherapy and chemotherapeutic drugs resulted in a low overall survival rate. Therefore, it is important to develop and explore alternative chemotherapy drugs, which can eff ectively treat OSCC, and clarify their mechanism of action. Objective The present study aimed to investigate the eff ect of three hexa-coordinated octahedral nickel (II) complexes, namely [Ni(sal- L -phe)(phen)(CH 3 OH)] CH 3 OH ( 1 ), [Ni(naph- L -phe)(phen)(CH 3 OH)] ( 2 ), and [Ni( o -van- L -phe)(phen) (CH 3 OH)] 5CH 3 OH ( 3 ), on proliferation, migration, and apoptosis of CAL-27 cells. Results The results of the study showed that complex 3 exhibited sensitive/signifi cant cytotoxicity toward CAL-27 cells, with an IC 50 value of 15.90 mΜ. Further, an assessment of the underlying mechanism showed that complex 3 could signifi cantly increase autophagy and reactive oxygen species (ROS) levels in CAL-27 cells. At the same time, it reduced mitochondrial membrane potential (MMP) in a dose-dependent manner. Additionally, complex 3 might act via inhibition of proliferation and migration of CAL 27 cells and induction of apoptosis, which was mediated via regulation of the expression of Bcl-2 family proteins in vitro. Conclusion The results of the study showed that nickel complexes could potently inhibit the growth of CAL-27 cells, which was mediated via mitochondrial dysfunction, intracellular ROS accumulation, and ROS-mediated DNA damage. Altogether, the fi ndings of the study would provide new leads for the designing and synthesis of novel metal drugs for OSCC.

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