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      • Research on Algorithm for Automatic License Plate Recognition System

        Zou Yingyong,Zhai Jian,Zhang Yongde,Cao Xinyan,Yu Guangbin,Chen Juhui 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1

        License plate recognition belongs to the field of computer vision and pattern recognition, and plays an important role in the field of intelligent transportation. The license plate location is a key technology in license plate recognition, the accurate positioning of a license or not directly affects the accuracy of character segmentation and character recognition, and has a direct impact on the efficiency of the license plate recognition system. In this paper, based on knowledge acquisition and knowledge reduction ability of rough set, as well as learning ability and generalization ability of neural network, a plate positioning system is constructed. On this basis, combined the rough set with neural networks and fuzzy logic, a rough fuzzy neural network recognition is proposed. The experimental results show that this system not only simplifies the structure of the system, but also improves the generalization capability of knowledge, and improves the accuracy of character positioning.

      • Research of Chinese Handwritten Text Segmentation Algorithm

        Zou Yingyong,Zhang Yongde,Cao Xinyan,Yu Guangbin 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.12

        OCR is a complicated process, there are many factors that can influence the recognition rate. Early period people tried to optimize the classifier to obtain high recognition rate, but the premise is that there is only one character no matter print or handwritten. For the performance of classifier has been promoted a lot, recognition rate for single character is high enough for commercial use. With the development of the demand for handwritten text recognition, how to raise the recognition rate of OCR system becomes very important. Unlike OCR system for print which focus on classifier. The research of OCR system for handwritten text is mainly on character segmentation. Statistical analysis showed that the mistake made by missegment is more than the mistake made by classifier. This is decided by the feature of handwritten text. There are more randomness and the lines are not horizontal, besides that, handwritten Chinese characters are more like overlapped and the gaps between characters are smaller. So this is the difficulty of handwritten Chinese characters. In this paper, the mutil-step searching nonlinear line exaction algorithm the paper proposed is easy and the accuracy is high, which can tackle the some weaknesses of direct projection method and indirect projection.

      • KCI등재

        Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation

        Zhang Wanying,Zou Guiling,Li Bin,Du Xuefei,Sun Zhe,Sun Yu,Jiang Xiaofeng 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.8

        Inflammatory bowel disease (IBD) is an increasing global burden and a predisposing factor to colorectal cancer. Although a number of treatment options are available, the side effects could be considerable. Studies on fecal microbiota transplantation (FMT) as an IBD intervention protocol require further validation as the underlying mechanisms for its attenuating effects remain unclear. This study aims to demonstrate the ameliorative role of FMT in an ulcerative colitis (UC) model induced by dextran sulfate sodium (DSS) and elucidate its relative mechanisms in a mouse model. It was shown that FMT intervention decreased disease activity index (DAI) levels and increased the body weight, colon weight and colon length of experimental animals. It also alleviated histopathological changes, reduced key cytokine expression and oxidative status in the colon. A down-regulated expression level of genes associated with NF-κB signaling pathway was also observed. The results of 16S rRNA gene sequencing showed that FMT intervention restored the gut microbiota to the pattern of the control group by increasing the relative abundance of Firmicutes and decreasing the abundances of Bacteroidetes and Proteobacteria. The relative abundances of the genera Lactobacillus, Butyricicoccus, Lachnoclostridium, Olsenella and Odoribacter were upregulated but Helicobacter, Bacteroides and Clostridium were reduced after FMT administration. Furthermore, FMT administration elevated the concentrations of SCFAs in the colon. In conclusion, FMT intervention could be suitable for UC control, but further validations via clinical trials are recommended.

      • Improved Multi-objective Genetic Algorithm Based on Parallel Hybrid Evolutionary Theory

        Zou Yingyong,Zhang Yongde,Li Qinghua,Jiang Jingang,Yu Guangbin 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1

        Based on the analysis on the basic principles and characteristics of the existing multi-objective genetic algorithm (MOGA), an improved multi-objective GA with elites maintain is put forward based on non-dominated sorting genetic algorithm (NSGA). NSGA-II algorithm theory and parallel hybrid evolutionary theory is described in detail. The design principle, process and detailed implementations of the improved MOGA are given. IMNSGA-II algorithm and NSGA-II algorithm are applied to test the performance of the two algorithms for different test function, experiments of example are preformed. Experimental results show that the improved MOGA achieved the optimal between the convergence and diversity.

      • Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating Myosin Light Chain Kinase Expression through Cross-talk with p38 MAPK

        Zou, Duo-Bing,Wei, Xiao,Hu, Ruo-Lei,Yang, Xiao-Ping,Zuo, Li,Zhang, Su-Mei,Zhu, Hua-Qing,Zhou, Qing,Gui, Shu-Yu,Wang, Yuan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

        Background: Melatonin, which is mainly produced by the pineal gland, has a good inhibitory effect on cell growth of multiple cancer types. However, the underlying molecular mechanisms of anti-tumor activity for colon cancer have not been fully elucidated. In this study, we investigated the effects of melatonin on migration in human colon cancer RKO cells and the potential molecular mechanisms. Materials and Methods: The viability of RKO cells was investigated by MTT assay after treatment with melatonin, SB203580 (p38 inhibitor) and phorbol 12-myristate 13-acetate (PMA, MAPK activator) alone or in combination for 48h. The effects of melatonin, and ML-7, a selective inhibitor of myosin light chain kinase (MLCK), and SB203580, and PMA on the migration of RKO cells were analyzed by in vitro scratch-wound assay. The relative mRNA levels of MLCK was assessed by real-time quantitative RT-PCR. Western blotting analysis was performed to examine the expression of MLCK, phosphorylation of myosin light chain (pMLC) and p38 (pp38). Results: The proliferation and migration of human colon cancer RKO cells were inhibited significantly after treatment with melatonin. The expression levels of MLCK and phosphorylation of MLC of RKO cells were reduced, and real-time quantitative RT-PCR showed that melatonin had significant effects on suppressing the expression of MLCK. Furthermore, the phosphorylation level of p38, which showed the same trend, was also reduced when cells were treated by melatonin. In addition, ML-7 (25umol/l) could down-regulate the phosphorylation of p38. Conclusions: Melatonin could inhibit the proliferation and migration of RKO cells, and further experiments confirmed that p38 MAPK plays an important role in regulating melatonin-induced migration inhibition through down-regulating the expression and activity of MLCK.

      • KCI등재

        Comprehensive evaluation of natural enemy dominant species of Breuipalpus oboyats in tea garden in autumn and winter

        Zhang Lin,Sun Jiazhao,Wu Xiaomeng,Xu Yu,Bi Shoudong,Zou Yunding 한국곤충학회 2021 Entomological Research Vol.51 No.12

        The purpose of this study was to comprehensively evaluate the dominant natural enemies of Breuipalpus oboyats in autumn and winter tea gardens. The relationship between natural enemies and B.oboyats in time and space was studied by niche analysis and geostatistics combined with angular cosine coefficient method. According to the comparison of the sum of closeness index, it is found that the top three natural enemies (from large to small) that are most closely related to B.oboyats in the “Nongkangzao” tea garden are Plexippus paykulli, Clubiona japonicola,and Xysticus ephippiafus; “Pingyangtezao” tea garden are X.ephippiafus, Plexippus setipet,andOxyopes sertatus. In front of the two tea gardens, one of the three natural enemies is the same. The evaluation of the comprehensive closeness index of the two tea gardens shows that the top three natural enemies most closely related to B.oboyats are X.ephippiafus, P.paykulli, and O.sertatus. X.ephippiafus is the most important natural enemy of B.oboyats in tea gardens in autumn and winter; the dominant natural enemies of the same pests in different varieties of tea gardens in the same area are often different.

      • KCI등재

        Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population

        Zou Yutong,Wang Danchen,Cheng Xinqi,Ma Chaochao,Lin Songbai,Hu Yingying,Yu Songlin,Xia Liangyu,Li Honglei,Yin Yicong,Liu Huaicheng,Zhang Dianxi,Zhang Kui,Lian Xiaolan,Xu Tengda,Qiu Ling 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.1

        Background: Thyroid diseases are highly prevalent worldwide, but their diagnosis remains a challenge. We established reference intervals (RIs) for thyroid-associated hormones and evaluated the prevalence of thyroid diseases in China. Methods: After excluding outliers based on the results of ultrasound screening, thyroid antibody tests, and the Tukey method, the medical records of 20,303 euthyroid adults, who visited the Department of Health Care at Peking Union Medical College Hospital from January 2014 to December 2018, were analyzed. Thyroid-associated hormones were measured by the Siemens Advia Centaur XP analyzer. The RIs for thyroid-associated hormones were calculated according to the CLSI C28-A3 guidelines, and were compared with the RIs provided by Siemens. The prevalence of thyroid diseases over the five years was evaluated and compared using the chi-square test. Results: The RIs for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), and total triiodothyronine (TT3) were 0.71–4.92 mIU/L, 12.2–20.1 pmol/L, 3.9–6.0 pmol/L, 65.6–135.1 nmol/L, and 1.2–2.2 nmol/L, respectively. The RIs of all hormones except TT4 differed significantly between males and females. The RIs of TSH increased with increasing age. The prevalence of overt hypothyroidism, overt hyperthyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism was 0.5% and 0.8%, 0.2% and 0.6%, 3.8% and 6.1%, and 3.3% and 4.7% in males and females, respectively, which differed from those provided by Siemens. Conclusions: Sex-specific RIs were established for thyroid-associated hormones, and the prevalence of thyroid diseases was determined in the Chinese population.

      • KCI등재

        Diffusion mechanism of deep shale gas and its carbon isotope fractionation: a combined simulated and mathematical analysis

        Yu Zou,Guojian Wang,Cheng Tao,Rui Zhou,Shangqing Zhang,Dongna Liu,Xiaohui Lin,Xuying Zheng 한국지질과학협의회 2023 Geosciences Journal Vol.27 No.3

        Unlike the release pressure process in shale gas exploitation, in this study, the concentration diffusion process is deeply discussed under constant temperature-pressure conditions, which aims to evaluate the preservation conditions of shale gas reservoirs in combination with isotopic fractionation characteristics. The isobaric diffusion experiment emphasized that decreasing pressure can lead to enhanced diffusion and isotope fractionation. The established mathematical model not only confirms the results of the simulating experiment, but also suggests that the contributions of Fick, Knudsen and surface diffusion to the migration of methane (including 12CH4 and 13CH4) vary in the geological evolution of shale reservoirs, which are mainly controlled by the pore system and gas pressure. Based on the analysis of specific samples of Longmaxi shale (r = 11.7 nm) and Niutitang shale (r = 1.3 nm), we propose that: 1) high pressure condition (> 20 MPa) can significantly limit Knudsen diffusion, which is the reason for reducing the total diffusion coefficient (DTotal) and isotope fractionation, while low pressure (< 10 MPa) and small pore radius (ca. 1 nm) can strengthen the fractionation; 2) pore connectivity and heterogeneity can lead to an order of magnitude change in DTotal, while the influence of temperature is relatively small. According to the mathematical model, it can be expected that enhanced dissipation intensity and isotope fractionation of shale gas may occur in the process of basin uplift and pressure relief, which can potentially be used for the evaluation of reservoir preservation.

      • KCI등재

        Biomechanical Evaluation of 2 Endoscopic Spine Surgery Methods for Treating Lumbar Disc Herniation: A Finite Element Study

        Yang Zou,Shuo Ji,Hui Wen Yang,Tao Ma,Yue Kun Fang,Zhi Cheng Wang,Miao Miao Liu,Ping Hui Zhou,Zheng Qi Bao,Chang Chun Zhang,Yu Chen Ye 대한척추신경외과학회 2024 Neurospine Vol.21 No.1

        Objective: This study aimed to evaluate the effects of 2 endoscopic spine surgeries on the biomechanical properties of normal and osteoporotic spines. Methods: Based on computed tomography images of a healthy adult volunteer, 6 finite element models were created. After validating the normal intact model, a concentrated force of 400 N and a moment of 7.5 Nm were exerted on the upper surface of L3 to simulate 6 physiological activities of the spine. Five types of indices were used to assess the biomechanical properties of the 6 models, range of motion (ROM), maximum displacement value, intervertebral disc stress, maximum stress value, and articular protrusion stress, and by combining them with finite element stress cloud. Results: In normal and osteoporotic spines, there was no meaningful change in ROM or disc stress in the 2 surgical models for the 6 motion states. Model N1 (osteoporotic percutaneous transforaminal endoscopic discectomy model) showed a decrease in maximum displacement value of 20.28% in right lateral bending. Model M2 (unilateral biportal endoscopic model) increased maximum displacement values of 16.88% and 17.82% during left and right lateral bending, respectively. The maximum stress value of L4–5 increased by 11.72% for model M2 during left rotation. In addition, using the same surgical approach, ROM, maximum displacement values, disc stress, and maximum stress values were more significant in the osteoporotic model than in the normal model. Conclusion: In both normal and osteoporotic spines, both surgical approaches were less disruptive to the physiologic structure of the spine. Furthermore, using the same endoscopic spine surgery, normal spine biomechanical properties are superior to osteoporotic spines.

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