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Zhenyi Zhang,Jianfei Chen,Zhibin Mo,Yutao Chen,Jie Huang 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.9
In this work, a behavior-based adaptive dynamic programming (BADP) method is proposed for the coordination control of unmanned ground vehicle-manipulator systems (UGVMs). Through a null-space-based behavioral control (NSBC) framework, the multi-objective coordination control is transformed into a single-objective tracking control at the mission layer. Since cost functions and control constraints are simplified at the control layer, the complexity of controller design is reduced. Then, an identifier-actor-critic reinforcement learning algorithm framework is introduced to learn the optimal control policy by balancing the control performance and consumption. Simulation results show that control costs are reduced by around 13.5% per sampling period compared to existing multiple objective control methods. Finally, the BADP method is experimentally validated using four real UGVMs.
Zhang, Xin,Huo, Haoran,Nie, Yanan,Xue, Jiadong,Yuan, Zengjiang,Zhang, Zhenyi The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.4
Purpose: Treatment options are limited after the failure of first-and second-line treatments in patients with HER2<sup>+</sup> metastatic gastric cancer (mGC). The present study aimed to explore the efficacy, safety, and prognostic factors of apatinib efficacy as a third-line therapy for patients with human epithelial growth factor receptor 2-positive (HER2<sup>+</sup>) mGC. Materials and Methods: A total of 59 HER2<sup>+</sup> mGC patients who received apatinib as third-line therapy were retrospectively enrolled in this two-center, single-arm, cohort study; the clinical response, survival data, and adverse events were retrieved. Results: The median progression-free survival (PFS) was 5.2 months (95% confidence interval [CI], 3.9-6.5), and the median overall survival (OS) was 8.2 months (95% CI, 6.6-9.8) Furthermore, forward stepwise multivariate Cox regression analysis showed that a higher Eastern Cooperative Oncology Group performance status score and multiple metastases were independently correlated with decreased PFS and OS (both P<0.05). The main adverse events were leukopenia (45.8%), hypertension (44.1%), thrombocytopenia (39.0%), hand-foot syndrome (37.3%), and elevated transaminase (33.9%). Grade 3 adverse events mainly included hypertension (5.1%) and neutropenia (5.1%); grade 4 adverse events did not occur. Conclusions: Apatinib is efficient and well tolerated in patients with HER2<sup>+</sup> mGC as a third-line treatment, suggesting that it may be a candidate of choice for these patients.
Zhu Jun,Li Guanghua,Cao Di,Zhang Zhenyi,Li Shuaihui 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.2
A 90° Halbach permanent magnet array coreless axial fux permanent magnet synchronous generator for wind power generation is compared with a conventional axial fux permanent magnet generator with cut cake type permanent magnet. 2D analytic model of generator is established. The air gap magnetic felds of two generators are analyzed by analytical method, and the air gap magnetic density and harmonic content are analyzed. Then the infuence of diferent parameters on voltage total harmonic distortion is analyzed by changing the pole arc coefcient, air gap length, permanent magnet thickness and number of turns. Two prototypes of generators are manufactured, and the correctness of the simulation results is verifed by experiments.